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Doxycycline In Pityriasis Rosea: Placebo- Controlled Clinical Trial

Authors: Sabeeh Al-Mashhadani --- Ghassaq Al-Timimi, --- Makram Al-Waiz
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 130-134
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Pityriasis rosea is an acute, self-limiting skin disease, probably of infective origin. Doxycycline is a broad-spectrum antibiotic, and most probably has an immunomodulator and an anti-inflammatory effect. Objective: To assess the efficacy of doxycycline in the treatment of pityriasis rosea in patients evaluated between January 2001 and May 2002. Patients and methods: This was a placebo-controlled clinical trial. One hundred and twenty patients with pityriasis rosea were included in the study; all of them were above 12 years of age. They had been divided into 2 groups, the treatment group consisted of 60 patients and received doxycycline capsule. 100,mg orally for 14 days and the placebo group consisted of 60 patients and received glucose capsules for 14 days, all the patients were followed up clinically for 4 weeks after treatment, the responses were categorized into excellent, partial and no response. Results: forty-six patients from the treatment group completed the study. Excellent response was achieved in 30 patients (65%), partial response in 15 patients (33.5%) and no response in I patient (1.5%). Forty patients from the placebo group completed the study. Excellent response was achieved in 4 patients (10%), partial response in 20 (50%) and no response in 16 patients (40%). The results were statistically significant. Conclusions: we concluded that doxycycline was effective in the treatment of pityriasis rosea, with very few adverse effects.


Article
The Frequency Of Chlamydial Urethritis Among ِA Group Of Iraqi Male Patients

Authors: Mahdei Y. mohammed --- Sabeeh Al-Mashhadani --- Makram M. Al-Waiz د.مكرم مكي الواعظ
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2007 Volume: 20 Issue: 2 Pages: 354-359
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground & Objective: The most important and potentially dangerous pathogen involved in non-gonococcal urethritis is Chlamydia trachomatis, so this study is conducted to evaluate the frequency of chlamydial urethritis among group of Iraqi male patients.Methods: The study design is a descriptive cross sectional study, including fifty two male patients complaining from urethral discharge, they were seen in the department of Dermatology and Venereology at Baghdad Teaching Hospital .Their ages ranged from 16-49 years (mean±SD 29.28Y±8.5).They were investigated using enzyme linked fluorescent assay to a direct urethral swabs for detection of chlamydial antigen.Results: Twenty one (40.38%) male patients were chlamydial antigen positive. Six of them (11.5%) had mixed infection (chlamydial and gonococcal urethritis).Chlamydial urethritis were most frequent at the third decade of life, those constitute of eight Patients (15.38%). Urethral discharge and dysuria were the most frequent symptoms which were noticed in all patients, frequency of micturation were seen in thirteen patients. Twenty patients were heterosexual and only one was homosexual; eight patients were practicing sex with single partner, the remainder practiced sex with multiple partners.Conclusion: Chlamydia is one of the common causes of urethritis among sexually active Iraqi male patients, enzyme linked fluorescent assay technique is simple reliable test in the diagnosis of this disease.Key words: Iraqi, chlamydial, urethritis

Keywords

Iraqi --- chlamydial --- urethritis

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