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Staphylococcus aureus with reduced vancomycin susceptibility among clinical isolates in Erbil City
المكورات العنقودية الذهبية مع انخفاض حساسية فانكومايسين بين العزلات السريرية في مدينة أربيل

Authors: Sabria M. Said Al-Salihi --- Aza Bahadeen Taha
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 1 Pages: 651-658
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Staphylococcus aureus (S. aureus) is responsible for a wide range of diseases and increased number of the strains that acquired resistance to antibiotics. The emergence of Vancomycin resistance of S. aureus has been a significant impact on human health. The distribution of Vancomycin minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) in S. aureus isolates, and compared antibiotic susceptibility to non-glycopeptideantibiotics in different Vancomycin MIC value groupswere assessed in this study.Methods: S. aureuswere isolated by standard method and subjected to MIC tested by broth microdilution method for Vancomycin and eight non-glycopeptideantibiotics, alsoVancomycin MBCs were determined.Results: Approximately 56% of S. aureus with a 0.5 µg/ml Vancomycin MIC were accounted, whereas 1.77% of S. aureushadan 8 µg/ml Vancomycin MIC. In other hand, most S. aureus had 1 and 2 µg/ml Vancomycin MBC.Conclusion: About half of the S. aureus isolates had 0.5 µg/ml of Vancomycin MIC. Relationship between Vancomycin MIC and resistance to non-glycopeptideantibiotics were observed, with increased Vancomycin MIC, the resistance to others antibiotics also elevated, and vice versa.


Article
Community and Hospital Acquired Infection of Methicillin-Resistant Staphylococcus aureus (MRSA) in Erbil City
حصول المجتمع والمستشفى على العدوى من المكورات العنقودية الذهبية المقاومة للميثيسيلين في مدينة أربيل

Authors: Sabria M. Said Al-Salihi --- Aza Bahadeen Taha
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 3 Pages: 52-60
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most frequently isolated pathogens in both community and hospitals, and associated with high morbidity and mortality rates with rapid development of resistance. The ethicillin-resistance occurs due to the presence of PBP2a of the bacterial cell wall, which has low affinity for β-lactam antibiotics. MRSA are often multi-resistant to both β-lactams and non-β-lactams antibiotics. The study was documented the occurrence of community and hospital acquired MRSA infections.Method: The clinical specimens were collected from patients at three teaching hospitals in Erbil city. All Staphylococcus aureus were identified as MRSA by detection of PBP2a.Results: Out of 377 Staphylococcus aureus isolated, 30.24% were MRSA. The wound was the most common infection site for both community and hospital acquired MRSA. Statistically the patients with hospital acquired MRSA were older than the community acquired MRSA.Conclusions: MRSA is one of the most common causes of serious infection in community and hospital settings. The most common site infected by MRSA is the surgical wound infection.


Article
BIOFILM FORMATION BY METHICILIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) WITHIN HOSPITAL AND COMMUNITY ACQUIRED URINARY TRACT INFECTIONS
تشكيل biofilm في المكورات العنقودية الذهبية المقاومة للمثسلين (MRSA) المسببة لالتهاب المسالك البولية المكتسبة من عدوى المستشفى والمجتمع

Authors: SABRIA M. SAID AL-SALIHI, صبريه سعيد الصالحي --- AZA B. TAHA ازا طه
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2012 Volume: 6 Issue: 1 Pages: 17-27
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background and objectives Methicillin resistant Staphylococcus aureus is a significant cause of life-threatening human infections, which can switch from planktonic forms (i.e. single cells) to biofilms. Biofilm formation was often-lower susceptibility to antibiotic treatments and development of chronic infections. The study was investigated biofilm formation by methicillin resistant Staphylococcus aureus isolated from patients with urinarytract infection. Meanwhile assess the relationship between biofilm formation and antibiotic resistance.Methods Staphylococcus aureus were isolated and identification by standard methods from urinary tract infections at three teaching hospitals in Erbil city. Methicillin resistant Staphylococcus aureus were detected by PBP2a. Heterogeneity of of methicillin resistantStaphylococcus aureus was determined by efficiency of plating method. Minimum inhibitory concentration of antibiotics was determined by agar dilution method. Biofilm forming abilityof methicillin resistant Staphylococcus aureus was investigated.Results Methicillin resistant Staphylococcus aureus were resistances to 10.92±3.17antibiotics. The percentage of biofilm formation by methicillin resistant Staphylococcus aureus was 82%. Strong biofilm formations were resistance to13.40±2.51 antibiotics, which is statistically higher than biofilm negative (Mean±SD = 6.56±1.51).Conclusions Most methicillin resistant Staphylococcus aureus were biofilm forming. Biofilm formation was correlated with multiple antibiotics resistance and to heterogeneous of methicillin resistant Staphylococcus aureus.

هى سبب مهم في العدوى التي تهدد (MRSA) خلفية واهداف البحث: المكو ا رت العنقودية الذهبية المقاومة للمثسلين غالبا ما تكون أقل biofilm تشكيل .biofilms إلى (planktonic) الحياة و التي يمكن ان تتحول من خلايا منفردة في المكو ا رت biofilm أستجابة للعلاج بالمضادات الحيوية وتسبب الالتهابات المزمنة. الد ا رسة تحققت من تشكيل العنقودية الذهبية المقاومة للمثسلين المعزولة من المرضى الذين يعانون من التهاب المسالك البولية. في الوقت نفسه تم والمقاومة للمضادات الحيوية. biofilm تقييم العلاقة بين تشكيل طرق البحث: تم عزل المكو ا رت العنقودية الذهبية بواسطة الطرق القياسية من التهابات المسالك البولية في ثلاث مستشفيات تعليمية في مدينة أربيل. تم الكشف عن المكو ا رت العنقودية الذهبية المقاومة للمثسلين بواسطة الكشف عن المكو ا رت العنقودية الذهبية المقاومة للمثسلين بواسطة طريقة heterogeneous MRSA تم تحديد .PBP2a تم تحديد الحد الأدنى للتركيز المثبطة للمضادات الحيوية بطريقة تخفيف الأكار. تمت الكشف .efficiency of plating في المكو ا رت العنقودية الذهبية المقاومة للمثسلين. biofilm عن قدرة تشكيل 3,17 من المضادات الحيوية. النسبة المؤية ± النتائج: المكو ا رت العنقودية الذهبية المقاومة للمثسلين مقاومة ل 10,92 ± قوي مقاومة ل 13,40 biofilm في المكو ا رت العنقودية الذهبية المقاومة للمثسلين كانت 82 ٪. تشكيل biofilm لتشكيل biofilm (=SD±Mean 2,51 من المضادات الحيوية وهى أعلى من الناحية الإحصائية في حال عدم تشكيلها ل 6,56 .(±1,51 ترتبط مع biofilm و تكوينها ل biofilm الاستنتاجات: معظم المكو ا رت العنقودية الذهبية المقاومة للمثسلين كونت مقاومتها للمضادات الحيوية.

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