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Serum Fructosamine and Related Biochemical Parameters in Pregnant Women with Pre-Eclampsia

Authors: Sahar Basheer Aziz --- Waad-Allah Shareef Mula-Abed
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 1 Pages: 61-75
Publisher: Babylon University جامعة بابل

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Abstract

The objective of this study is to determine the pattern of change in serum fructosamine and related biochemical parameters in normally pregnant women and to compare them with pregnant women complicated with pre-eclampsia and also to examine the influence of serum albumin or total protein on fructosamine concentrations with the need for correcting their values accordingly. Fasting plasma glucose (FPG) and serum fructosamine (FAm), albumin and total protein were measured in three groups of women who were attending Al-Batool antenatal clinic and Al-Khansa antenatal clinic in Mosul during the period of 7 months from 1st November 2000 to 31st May 2001. These included 250 non-pregnant apparently healthy women (group 1), 242 normally pregnant women (group 2) and 53 pregnant women complicated by pre-eclamptic toxaemia (group 3). The distribution of serum FAm in group 1 showed a normal (Gaussian] pattern with reference range calculated as mean ± 2SD of 1.37-2.49 mmol/L. In group 2, a significantly lower FAm values were observed (Z=4.1, p<0.001) with no significant correlation between FAm and albumin or total protein. There was a downward trend in FAm values with the progress of pregnancy as their means were (1.82, 1.80, 1.77 mmol/L) in the early, middle and late stages respectively which were significantly lower than the mean value of 1.93 mmol/L in group 1. Serum albumin and total protein showed also a trend to decrease during the gestational stages with a highly significant difference from group 1 (p<0.001). FPG showed no significant difference in all stages from group 1. Correction of FAm for albumin or total protein is required in group 2 and comparison between corrected fructosamine (FAc) in group 1 and group 2 revealed no significant difference. In group 3, lower FAm values were obtained with mean ± SD of 1.60 ± 0.27 mmol/L, which is significantly (p<0.001) lower than group 1 (Z=6.2) and group 2 (Z=3.4). There was also a tendency for mean FAm to decrease with the increase in the degree of proteinuria. Following correction according to albumin or total protein, the difference was eliminated as compared with group 2, but in comparison with group 1 the difference was eliminated only when correction according to total protein was made. These data highlight the importance of measuring serum fructosamine in women during pregnancy. Its concentration is affected by the changes in serum albumin and total protein during the different stages of gestation. In pregnancy complicated by pre-eclamptic toxaemia, correction of fructosamine according to albumin or total protein, is mandatory as the values differ from those in non-pregnant and normal pregnant women.

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Article
Maternal and Cord Blood Fructosamine in Normally Pregnant Women During Delivery

Authors: Waad-Allah Shareef Mula-Abed --- Sahar Basheer Aziz
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 253-260
Publisher: Babylon University جامعة بابل

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Abstract

To compare between serum fructosamine values in maternal and cord blood and the relationship with birth weight, serum albumin or total protein concentration as well as the influence of albumin or total protein on fructosamine values and the need for correcting their values accordingly using different equations. Plasma glucose (PG) and serum fructosamine (FAm), albumin and total protein were measured in maternal and cord blood from 20 full-term pregnant women delivered by normal vaginal delivery women. Calculation of corrected fructosamine (FAc) was made according to serum albumin or total protein values using different equations. The pregnant women were attending Al-Batool Maternity Hospital in Mosul during April 2001. When comparing the maternal and cord blood parameters, there was no significant difference in PG and albumin concentrations, while there was a slight significant difference between them in FAm (p<0.01), and a highly significant difference in total protein (p<0.001). There was no significant correlation between the weight of the baby and FAm of the maternal blood (r=0.08) or cord blood (r=0.18). There was also no significant correlation between FAm and albumin in the cord blood (r=0.31) or maternal blood (r=0.07). After correction, comparison between FAm and FAc showed a slight difference between FAc and FAm in the maternal blood (P< 0.05 based on albumin and p<0.001 based on total protein). In the cord blood, FAm showed also a highly significant difference from FA (P< 0.001). There was no significant difference between FAc in the cord blood and in the maternal blood using all equations. Cord blood fructosamine was lower than maternal blood fructosamine with no significant correlation was found between weight of baby and maternal fructosamine or cord blood fructosamine. Correction of measured fructosamine accordingly improves its usefulness as an index of glycated protein for assessing glycaemic state.

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