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Article
The influence of menopause on unstimulated salivary flow and subjective oral dryness inrelation to other oral symptoms and salivary gland hypofunction

Author: Sahar H. Alani سحر حمدان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 78-80
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The aim of the present study was to evaluate unstimulated salivary flow rate and oral symptoms inmenopausal women.Materials and Methods: A total of 200 individuals including 100 women in their menopause (case group) and 100men in the same age range (control group) participated in this analytic descriptive investigation. None of thepatients were being treated for any systemic disease or taking any medication. Unstimulated salivary flow rate wasmeasured using the spitting method and the prevalence of oral symptoms was evaluated by filling out aquestionnaire. The results were analyzed with ANOVA, chi-square and Student’s t-test (P<0.05).Results: The average of unstimulated salivary flow rate was 0.127 ml/min (SD=0.057) in women and 0.214 ml/min(SD=0.105) in men. The prevalence of dry mouth was 50% versus32%, difficulty in eating dry foods 31% versus 8%,burning sensation in oral mucosa 3% versus 0%, taste reduction, 4% versus 2% and bitter or metallic taste 16% versus8% in female and male subjects, respectively.Conclusion: A significant difference in salivary flow rate and prevalence of oral symptoms was found between thetwo groups (P<0.05). Reduced salivary flow rate and a high prevalence of oral symptoms in menopausal womenmay be related to the hormonal alterations that occur during this period

Keywords

menopause --- salivary flow


Article
Determination the concentration of insulin-like growth factor-I (IGF-I) in saliva of acromegalic patients, and comparison it with the levels of serum IGF-I.

Authors: Shiamaa Zwain --- Sahar H. Alani --- Abdilkarim Yahia Alsammariae عبد الكريم يحيى السامرائي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 2 Pages: 47-50
Publisher: Baghdad University جامعة بغداد

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Abstract

Acromegaly is ametabolic disorder characterized by an acquired progressive somatic disfigurement, mainly involving the face, extremities and many other organs, that are associated with systemic manifestations, caused by excessive secretion of growth hormone and a resultant persistent elevation of insulin-like growth factor-I concentrations. In more than 90% of cases originates from a monoclonal benign pituitary adenoma. Aim of this study to assess the level of insulin-like growth factor-I (IGF-I) in saliva of acromegalic patients, and to compare it with the basal levels of serum IGF-I. Sixty specimens of serum and saliva collected from two groups of subjects (forty acromegalic patients and twenty healthy persons). The specimens were centrifuged and stored at -20ºC then IRMA kits were used for estimating insulin like-growth factor-I. The results show that acromegalic patients had significantly higher salivary insulin like growth factor-I concentrations than healthy subjects (mean 21.26 vs. 20.48ng/mL; p=0.041), serum insulin like growth factor-I concentrations (mean 782.21 vs. 199.87ng/mL; p<0.001), there is significant correlation between salivary and serum insulin like growth factor –I in acromegalic group, whiles no significant correlation in control group, Salivary IGF-I concentration may not represented the corresponding serum concentration adequately, so cannot be considered it as alternative diagnostic tool to the acromegalic patients.

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