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Article
The role of Herpes simplex virus type 1 and 2 in patients with neurodegenerative diseases

Authors: Mohamad I. Hassan --- Rana S. Aboud --- Saife D. Al-Ahmer
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2018 Volume: 59 Issue: 4C Pages: 2179-2183
Publisher: Baghdad University جامعة بغداد

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Abstract

With the growing number of patient’s being diagnosed with Parkinson’s disease and Multiple Sclerosis each year it is becoming ever more important to find the cause for these neurological disorders. The present study attempts to shed light on one of the factors that may play a role as a causative agent in these neurological diseases by finding a correlation between the Herpes simplex virus type 1 and 2 in patients with Parkinson’s disease and multiple sclerosis by detecting the virus in these patients using immunological techniques. Sixty patients with neurological diseases (40 patients with Multiple sclerosis and 20 patients with Parkinson’s disease) who’s ages ranged from (17-76) years have been investigated. Samples were collected during the time period between November 2017 and April 2018 and compared to twenty five apparently healthy individuals as a control group. All the studied groups were measured for herpes simplex virus type-1 IgM and herpes simplex virus type-2 IgM by using the enzyme linked immuno sorbent assay. The results of the present study showed that there was a highly significant difference (p<0.01) in the concentration of IgM HSV-1 and HSV-2 in the sera of patients with MS and PD compared to the control group, While there was a none-significant difference (p>0.05) in the concentration of IgM HSV-1 and HSV-2 according to the gender. Thus, there is a likely possibility the HSV could be a contributing factor in the activation of some neurological diseases by the means of initiating an autoimmune reaction against the host’s nerve cells. The nerve cells have proteins that resemble portions of the virus from a structural and genetic stand point.


Article
Using of Hybrid Nanoantibiotics as Promising Antimicrobial Agent

Author: Saife D. Al-Ahmer , AbdulMuhsin M. Shami , Basima Q.Hasan AL-Saadi
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 3 Pages: 1-16
Publisher: Baghdad University جامعة بغداد

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Abstract

Nanoparticles are particles with size 1-100 nm, which exhibit different shapes like spherical, triangular, rod, etc. Research on synthesis of nanoparticles is the current area of interest due to the unique visible properties (chemical, physical, optical) of nanoparticles compared with the bulk material. Owing to the wide range of applications offered by nanoparticles in different fields of science and technology, different protocols have been designed for their synthesis. The nanoparticles can be synthesized using the top-down (physical) approach which deals with methods such as thermal decomposition, diffusion, irradiation, arc discharge, and bottom-up (chemical and biological) approach,which involves seeded growth method, polyol synthesis method, electrochemical synthesis, chemical reduction, and biological entities for fabrication of nanoparticles. Different synthesis methods involve the use of different types of chemical, physical, and biological agents to yield nanoparticles of different sizes and shapes. The most often used method for the chemical synthesis of nanoparticles is the chemical reduction method, which deals with the reduction of metal particles to nanoparticles using chemical reducing agents like sodium borohydride or sodium citrate.


Article
Molecular Characterization of Malassezia furfur isolated from patients with pityriasis versicolor compared to healthy control in Baghdad, Iraq
التوصيف الجزيئي للفطر Malasszia furfur المعزولة من مرضى النخالية المبرقشة في بغداد

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Abstract

Background: Humans skin, is the largest organ of the integumentary system, it has multiple layers of ectodermal tissue and guards the underlying muscles, bones, ligaments and internal organs. Pityriasis versicolor is the prototypical skin disease etiologically connected to Malassezia species. Malassezia furfur is the primary causative agent of pityriasis versicolor which causes either hyperpigmentation or hypopigmentation of the skin.Objective: To identify of Malassezia furfur associated with pityriasis versicolor patients and healthy control by using molecular detection methods.Material and Methods: Sixty patients suffering from pityriasis versicolor disease who attended Medical Imammaine Kadhmain City from beginning of 1st December 2013 to the 30th of April 2014. Clinical diagnoses were done by consultant dermatologist. Forty were males and twenty were females with a mean age of (28.63 ± 11.83) years old. Control group includes skin swabs collected from 120 healthy volunteers, with ages ranging from 1 to 70 years with a mean of (30.03 ± 14.58 years). Both groups were investigated for M. furfur using phenotypic and molecular characterization.Results: According to the gender, pityriasis versicolor was more infection in males than females with (68.3%). Malassezia furfur had a high percentage with male of pityriasis versicolor patients and healthy volunteers (65.0% and 73.1%, respectively). According to the site of lesions, Malassezia furfur was most isolated from chest site with percentage (35.0%) while in healthy volunteers, Upper limbs and chest were most site lesions associated with M. furfur with a percentage (23.1%).Conclusions: It was concluded that pityriasis versicolor was more common in male than female. Also the chest site was most the lesions associated with Malassezia furfur in pityriasis versicolor patients. Key words: Malassezia furfur, Pityriasis versicolor.

خلفية الموضوع: جلد الأنسان هو العضو الأكبر للنظام أذ يتكون من طبقات متعددة من أنسجة البشرة تحتها عضلات وعظام وأعضاء داخلية أخرى. النخالية المبرقشة هو مرض جلدي سببه يعود لفطر المالاسيزيا. نوع Malassezia furfur هو السبب الرئيسي للمرض والذي يسبب تغيرات لونية أعلى وأسفل الجلد.الهدف: تشخيص الفطر المدروس المصاحب لمرضى النخالية المبرقشة والأشخاص الأصحاء بأستخدام طرق التشخيص الجزيئية.المواد وطرائق العمل: ستون مريضا" مصابين بالمرض ممن راجعوا مدينة الأمامين الكاظمين الطبية. مئة وعشرون متطوعا" من الأشخاص الأصحاء ابتداءا" من الأول من شهر كانون الأول 2013 الى الثلاثين من نيسان 2014. تشخيص المرض تم تحت أشراف أستشاري الأمراض الجلدية. أربعون مريضا" من الذكور وعشرين مريضة. أما للأشخاص الأصحاء فقد تم جمع المسحات الجلدية من 120 شخص ممن تتراوح أعمارهم من1-70 سنة. الدراسة تمت بزرع العينات بأستخدام الطرق المظهرية والجزيئية. النتائج: الذكور أكثر المصابين بالمرض مقارنة بالاناث وبنسبة (68.3%) الفطر كان أكثر أصابة بالذكور عند المصابين والأصحاء وبنسبة (65.0% و 73.1%) على التوالي. منطقة الصدر كانت أكثر المناطق أصابة بالفطر مقارنة بالمناطق المصابة الأخرى وبنسبة35.0%) بينما الأطراف العليا والصدر كانت أكثر مصابة بالفطر عند الأشخاص الأصحاء وبنسبة (23.1%).الأستنتاجات: نستنتج بأن الذكور أكثر عرضة للأصابة بالمرض من الأناث. منطقة الصدر أكثر المناطق عزل منها الفطر لدى المصابين بالمرض بينما الأشخاص الأصحاء فكانت الأطراف العليا أكثر المناطق عزل منها الفطر.مفتاح الكلمات:, النخالية المبرقشة , Malassezia furfur


Article
The role of Helicobacter pylori infection in skin disorders
دور الخمج بالبكتريا الملتوية البوابية في المتلازمات الجلدية

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Abstract

This study was amied to determine the relationship between Helicobacter pylori infection and skin disorders, sixty six patients who suffering from skin diseases (Urticaria and atopic dermatitis) who attended at Dermatological Clinic Al-Numan Teaching Hospital. Aged (6--62) years have been investigated and compared to Twenty two samples of apparently healthy individual's were studied as control group . All the studied groups were subjected to measurement of anti- Helicobacter pylori antibodies IgA by Enzyme linked immunosorbent assay (ELISA). The results of current study revealed that there were a significant elevation (P<0.05) in the concentration of H. pylori IgA antibodies in sera of patients with chronic urticaria and atopic dermatitis compared to control group, and there were non significant differences (P>0.05) in the concentration of H. pylori IgA Ab in sera of patients according to the ages and gender. Conclusion, Helicobacter pylori may have a role in the pathogenesis of chronic urticaria and atopic dermatitis, and the results of present study suggest that H.pylori infection should be included in diagnostic workup of patients with skin disorders.

هدف الدراسة لتحديد العلاقة بين الخمج بالبكتريا الملتوية البوابية والمتلازمات الجلدية تم التحري عن ( 66) مريض يعانون من الامراض الجلدية (الشري والتهاب الجلد التاتبي) من الذين يقصدون قسم الامراض الجلدية في مستشفى النعمان التعليمي وكانت متوسط أعمارهم(6-62 سنة ) وتمت المقارنة مع (22) من الأشخاص الأصحاء ظاهريا وعدت مجاميع سيطرة. خضعت جميع عينات الدراسة لقياس تركيز اضدادIgA للبكتريا الملتوية البوابية بواسطة تقنية الامتزاز المناعي المرتبط بالانظيم. أظهرت نتائج الدراسة ارتفاعا معنويا (P<0.05 ) في التركيز أضداد IgA للبكتريا الملتوية البوابية في مصول المرضى المصابين بالشري والتهاب الجلد التاتبي مقارنة مع مجاميع السيطرة ولم يلاحظ ارتفاعا معنويا (P>0.05) في تركيز اضداد IgA للبكتريا الملتوية البوابية في مصول المرضى وفقا للعمر والجنس.الاستنتاج: يمكن أن تلعب البكتريا الملتوية البوابية دورا في امراضية الشري والتهاب الجلد التاتبي وتقترح نتائج الدراسة الحالية بان يكون التحري عن البكتريا الملتوية البوابية متضمنا في الفحوصات الروتينية للمتلازمات الجلدية.

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