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Relation of Prostate Specific Antigen and Histopathology of Prostate Biopsy
علاقة مستضد البروستات النوعي والتشريح المرضي لخزعة البروستات

Authors: Payman Anwar Rashid --- Salah Abu baker
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 22-27
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Prostate cancer is now the commonest cancer in men and the second commonest cause of cancer death after lung cancer. The introduction of pros-tate specific antigen (PSA) testing has revolutionized the early detection, management and follow-up of patients with prostate cancer and it is considered to be one of the best bio-chemical markers currently available in the field of oncology. This prospective study was aimed to Evaluate the diagnostic performance characteristics of prostate specific antigen (PSA) by comparing serum PSA value with histopathological finding of prostate biopsy , Determine the relation between PSA and various prostatic diseases, and To explain the effect of age on PSA testing.Methods: To fulfill these objectives, 92 specimens of prostate biopsy from patients with history of prostatism who underwent prostate surgery (prostatectomy, TURP and true cut biopsy of prostate) with samples of serum for tPSA analysis taken preoperatively during a period of 10 months. In addition to 33 samples of serum taken from apparently healthy indi-viduals for tPSA analysis.Results: From 92 cases 12 of them were malignant, 49 cases were BPH and 31 cases were BPH with prostatitis. Statistically there was significant relation between PSA values and histopathological findings of prostate biopsy and significant relation between age and PSA value of apparently healthy individuals. PSA sensitivity was (100%), specificity (46.25%), PPV (21.8%), and NPV (100 Sensitivity of PSA testing was better than specific-ity.Conclusions: It is concluded that PSA evaluation is a sensitive marker for prostate can-cer but because of various other conditions that affect serum PSA concentration. Other methods of investigations such as DRE, TRUS and histological examination should be combined to confirm diagnosis.


Article
Open-label uncontrolled pilot study on antipsoriatic activity of Rosa hemisphaerica
دراسة تجريبية مفتوحة غير مضبوطة على النشاط المضاد للذهان ل Rosa hemisphaerica

Authors: Salah Abu Baker Ali --- Alaadin M. Naqishbandi --- Lana Y. Muttalib --- Aveen N. Adham
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 1 Pages: 1636-1644
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Rosa hemisphearica (Rosaceae) is highly cultivated worldwide as an ornamental plant and medicinally have an antibacterial and antioxidant effect. This study aimed to investigate clinically and histopathologically the anti-inflammatory activity of Rosa hemisphearica in psoriasis and to correlate the anti-inflammatory activity with the active constituents in the plant by the phytochemical study.Methods: In this open-label uncontrolled pilot study, a topical preparation of R. hemisphearica stem extract was used by 20 patients suffering from psoriasis for three weeks. Three histopathological slides for each patient, one each week for three weeks was done for anti-inflammatory response evaluation. Subsequently, total phenolic content was measured followed by thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis for the identification of phenolic acid content in the stem.Results: By histopathological examination revealed that both Munro’s and Kogoj’s abscesses were gradually disappeared, the granular layer gradually restored to normal and the inflammatory cells gradually reduced in number prominently polymorph (neutrophils) and eventually histocytes disappeared. Total phenolic contents in R. hemisphearica stem extract were determined as 205.625 µg gallic acid equivalent each gm of the sample extract, TLC, and HPLC results showed the presence of rosmarinic acid in the stem extract. On quantitative HPLC analysis, the percentage of rosmarinic acid in the stem extract was 0.024 with a retention time (Rt) of 3.4 min. The proposed HPLC method was found to be linear, accurate and precise.Conclusion: The organic solvent extract of R. hemisphearica stem showed a significant reduction in an inflammatory cell among psoriatic patients under study. Rosmarinic acid was identified by TLC and HPLC as important phenolic acid constituents.


Article
Histopathological Study of BCC in Rizgari Teaching Hospital

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Abstract

This study include (66) case of Basal cell carcinoma (BCC). The age of the patients ranged from (21 – 80) year. The highest percentage of patients was seen related to the age group (61 – 70) year. The total male to female ratio was 1.1:1. The most common histological type was the solid and the most common site of occurrence was the nose. No significant difference was found between site distribution and sex of the patients. The percentage of cases with apparent palisading pattern was (83.1%) and mostly seen related to the solid type. Significant difference was found between peripheral palisading pattern and histological types of BCC. Most cases showed apparent inflammatory reaction, no pigmentation, and involved margin by tumor cells. No significant difference was found between inflammatory reaction, presence of pigmentation, involvement of surgical margins, and histological types of BCC.This study include (66) case of Basal cell carcinoma (BCC). The age of the patients ranged from (21 – 80) year. The highest percentage of patients was seen related to the age group (61 – 70) year. The total male to female ratio was 1.1:1. The most common histological type was the solid and the most common site of occurrence was the nose. No significant difference was found between site distribution and sex of the patients. The percentage of cases with apparent palisading pattern was (83.1%) and mostly seen related to the solid type. Significant difference was found between peripheral palisading pattern and histological types of BCC. Most cases showed apparent inflammatory reaction, no pigmentation, and involved margin by tumor cells. No significant difference was found between inflammatory reaction, presence of pigmentation, involvement of surgical margins, and histological types of BCC.Key wards: Skin cancer, BCC.

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