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Article
Computer Assisted Immunohistochemical Score Prediction Via Simplified Image Acquisition Technique

Authors: Salam N. Jawad --- Bashar H. Abdullah
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 1 Pages: 83-88
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: techniques of image analysis have been used extensively to minimize interobserver variation of immunohistochemical scoring, yet; image acquisition procedures are often demanding, expensive and laborious. This study aims to assess the validity of image analysis to predict human observer’s score with a simplified image acquisition technique.Materials and methods: formalin fixed- paraffin embedded tissue sections for ameloblastomas and basal cell carcinomas were immunohistochemically stained with monoclonal antibodies to MMP-2 and MMP-9. The extent of antibody positivity was quantified using Imagej® based application on low power photomicrographs obtained with a conventional camera. Results of the software were employed to predict human visual scoring results with stepwise multiple regression analysis.Results: the overall prediction of epithelial score depicted as r square value was 0.26 (p<0.001) which was obviously higher than that of stromal score (0.10; p<0.01). Epithelial and stromal MMP-2 score prediction was generally higher than that of MMP-9. Collectively, ameloblastomas had a more efficient score prediction compared to basal cell carcinomas.Conclusion: there is a considerable variability in the prediction capacity of the technique with respect to different antibodies, different tumors and cellular versus stromal score


Article
Histological and histomorphometric analysis of strontium chloride coated commercially pure titanium implant compare with hydroxyapatite coating

Authors: Ghasak H. Jani --- Shatha S. Al-Ameer --- Salam N. Jawad
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 1 Pages: 26-31
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: In recent years, the immediate loading of dental implants has become more accepted as a standardprotocol for the treatment of the edentulous area. Success in implant dentistry depends on several parameters thatmay improve phenomenon of osseointegration and new bone formation in close contact with the implant. The aimof study was to evaluate the effect of strontium chloride coating of screw shape commercially pure titanium dentalimplant osseointegration at bone - implant interface by histomorphometric analysis and compare withhydroxyapatite coating at 2 time periods (2 weeks and 6 weeks).Materials and methods: Electrophoretic Deposition Technique (EPD) was used to obtain a uniform coating layer oncommercially pure titanium screws. The tibia of 4 white New Zealand rabbits was chosen as implantation sites. Eachtibia of rabbit received two screws, one strontium chloride coated and one hydroxyapatite coated and a total 30histological sections were obtained for each coating material in each period of time. Histomorphometric analysiswas performed to measure new bone formed ratio between implant and original bone, after 2 and 6 weeks healingperiods.Results: There was increased in new bone formation ratio for the strontium chloride coated implants thanhydroxyapatite coated implants and over the two periods of time. There was an increase in the new bone formationratio at bone-implant interface with time.Conclusion: Coating commercially pure titanium implant with strontium chloride was more efficient in increasingosseointegration at bone implant interface than hydroxyapatite , which was demonstrated by higher new boneformation and maturation at the two periods of time 2 weeks and 6 weeks after implantation


Article
Primary Amelanotic Melanoma of the Tongue (Case Report)

Authors: Bashar H. Abdullah --- Aliaa M. Waheeb --- Aliaa M. Waheeb2 --- Salam N. Jawad
Journal: Journal of Oral and Dental Research مجلة طب الفم والاسنان ISSN: 23106417 Year: 2014 Volume: 1 Issue: 2 Pages: 10-12
Publisher: Iraqi Association for Oral Research الجمعية العراقية لبحوث طب الفم

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Abstract

A case of a 41 years old male with a nodular lesion at the tip of the tongue is presented. Incisional biopsy showedmalignant growth with nonspecific features. Although the lesion showed no pigmentation; positivity for Melan-Awas detected leading to the diagnosis of Amelanotic melanoma. The patient was treated later with excision andneck dissection.

Keywords

Amelanotic --- Oral --- Melanoma --- Tongue


Article
Immunohistochemical Expression of Endocan in Ameloblastoma

Authors: Salam N. Jawad سلام نهاد جواد --- Bashar H. Abdullah بشار عبد الله
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 4 Pages: 68-71
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Ameloblastoma is the most common clinically significant odontogenic tumor, known for its locally invasive potential and frequent recurrences unless treated radically. Endocan is a soluble proteoglycan which is reported to have prognostic implications in multiple human diseases and tumors. This study aims to describe the expression of endocan in ameloblastoma.Materials and methods: With immunoperoxidase method; tissue sections of formalin fixed- paraffin embedded blocks for ameloblastomas were stained with monoclonal antibodies to endocan, the localization of the endocan expression was examined and the resulting scores of the tissue sections were analyzed according to age, sex, site and tumor subtype.Results: endocan was found to be expressed in peripheral and central epithelial cells of ameloblastoma tumor islands and stroma to different extents; a selectively increased expression was noted in epithelial cells with acanthomatous differentiation. Tumor epithelial cells of plexiform subtype tend to have higher expression levels of endocan. However, the associations did not reach statistically significant levels.Conclusions: Endocan is expressed specifically in various populations of tumor epithelial cells and stromal elements of ameloblastoma. The prognostic significance of the expression needs to be clarified in further studies

Keywords

Ameloblastoma --- Endocan

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