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LEAD EXPOSURE EFFECTS ON BATTERIES MANUFACTURING FACTORY WORKERS IN BAGHDAD

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Abstract

Background :Lead is an environmentally persistent toxin that causes pathologies and induced oxidative stress by reactive oxygen species (ROS) causing reduction of antioxidants and a weakening of defense system of the cell.Objective:To evaluate the occupational lead level and its impact on workers in Batteries Manufacturing Factory / Baghdad.Method:Blood, hair and urine samples were taken from 45 occupational lead exposed workers in Batteries Manufacturing Factory in Baghdad with age ranged (25-63) years during the period from October 2010 to the end of January 2011. Flame and flameless Atomic Absorption spectrophotometer were used in the measurements of blood lead and hair lead concentrations, HPLC was used in the measurement of vitamin E concentration, and ELISA was used for the determination of 8-Hydroxydeoxyguansin concentration.Results:The results in this study showed a high concentration of lead in blood and hair for exposed workers in comparison with the normal corresponding values for the control. The results also showed that there was a significant decrease in δ –Aminolevulinic acid dehydratase activity, a low level of vitamin E in the serum and an increase in the level of 8-Hydroxydeoxyguansin in urine of exposed workers.Conclusion:The correlation between oxidative stress parameters and clinical indices implies that there is a disrupted antioxidant balance which might contribute to lead induced toxicity in erythrocytes.Keywords:Lead exposure, δ–Aminolevulinic acid dehydratase, 8- Hydroxydeoxyguansin, Antioxidants, Lead battery.


Article
ADSORPTION OF GLIMEPIRIDE ON ACTIVATED CHARCOAL AND IRAQI KAOLIN FROM AQUEOUS SOLUTION

Authors: Samir M Jasim سمير محمود جاسم --- Rayah S Baban ريا سليمان بابان --- Hiba S Jasim هبه سوادي جاسم
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2013 Volume: 11 Issue: 1 Pages: 24-32
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Treatment of acute poisoning due to drug overdose in general depends on the prevention of further absorption of the drug and acceleration of elimination, using specific antidotes. Drugs adsorption is of significant importance in physical pharmacy for the preparation of physical antidotes.Objective:To investigate the adsorption of glimepiride from aqueous solution on two adsorbents (activated charcoal and Iraqi kaolin).Method:UV-Spectrophotometric technique was used to obtain the quantitive adsorption data at different conditions of pH and temperature.Results:The quantities of glimepiride adsorbed on activated charcoal and kaolin were increased with decreasing temperature. Adsorption isotherms of glimepiride on both surfaces were consistent with Freundlich adsorption isotherm. Thermodynamic functions (∆G, ∆H and ∆S) were useful in describing the spontaneity of the adsorption process.Conclusion:The quantity of the drug that is adsorbed on activated charcoal was higher than that adsorbed on kaolin surface therefore; the activated charcoal is a better antidote.Keywords:Glimepiride, Adsorption, Activated charcoal, Iraqi kaolin


Article
A new approach for the topical treatment of acne vulgaris by clindamycin HCL supported on kalion
طريقة جديدة للعلاج الموضعي لحب الشباب بأستعمال الكلندامايسين هيدروكلورايد المحمول على الكاؤلين

Authors: Samir M. Jasim سمير محمود جاسم --- Saadon A.Isa سعدون عبد العزيز عيسى --- hussein K.A Hussein حسين كاظم عبد الحسين
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2006 Volume: 3 Issue: 2 Pages: 329-335
Publisher: Baghdad University جامعة بغداد

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Abstract

Has been studied both processes Almetzaz and extortion of a substance Alklanda Maysan different amounts of Alcaúlan Guy 70% alcohol solution using the method when the wavelength

لقد تمت دراسة كل من عمليتي المتزاز والابتزاز لمادة الكلندا مايسين على كميات مختلفة من الكاؤولين غي محلول ٧٠% كحول باستعمال طريقة عند الطول الموجي

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