research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Alterations in malondialdehyde levels and superoxide dismutase activity in the sera of occupational workers in Erbil city
تغيرات في مستويات malondialdehyde ونشاط superoxide dismutase في الأمصال من العاملين في مدينة أربيل

Authors: Abdul-Qadir A Hassan --- Nadir M Nanakali --- Sardar N Ahmed --- Gaylany H Abdullah
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 1 Pages: 638-644
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objective: Malondialdehyde is the end product of lipid peroxidation by oxidative stress (free radicals). Superoxide dismutase is one of the important antioxidant enzymes that catalyze conversion of superoxide to hydrogen peroxide. The aim of present study is to measure the serum Malondialdehyde concentration and Superoxide dismutase activity in occupational workers.Methods: A prospective study was carried out from October 2011 to May 2012 in collaboration between clinical biochemistry department at the College of Medicine-Hawler Medical University and chemistry department at the faculty of science and health at Koya University. Total of thirty non-office occupational workers were targeted, who exposed to air and industrial material pollutions, all individuals were healthy and non-alcoholics.Results: The mean value of each of the serum Malondialdehyde concentration and serum Superoxide dismutase activity were significantly higher in occupational workers than that of non-occupational workers.Conclusion: Based on findings of the present study it can be concluded that occupational works elevates the release of Superoxide dismutase enzyme, and also increases lipid peroxidation by reactive oxygen species which in turn causes elevation of Malondialdehyde.


Article
Estimation of Serum Malondialdehyde and Uric acid levels in Smokers and non-Smokers
تقدير مستوى المالوندايالديهايد وحامض اليوريك في مصل دم المدخنين وغير المدخنين

Loading...
Loading...
Abstract

Malondialdehyde (MDA) is one of many low molecular weight end-products of lipid peroxidation; it is as an index of lipid peroxidation. Uric acid is one of the endogenous oxidant-antioxidant paradoxes.The aim of this study is to evaluate the levels of serum MDAand uric acid insmokers and non smokers. This study was carried out from January to July 2012 on (30) smokers and (30) non smokers.Serum MDA level was measured spectrophotometrically using thiobarbituricacid method, whereas serum uric acid was measured using enzymatic colorimetric method.The results of the study revealed a significant increase (P<0.001) in uric acid value in smokers subjects compared to non smokers (6.54 ± 0.37 Vs 4.68 ± 0.22) respectively, while no significant difference (P>0.05)In MDA value was observed in smokers and non smokers subjects (2.227 ± 0.394 Vs 1.912 ± 0.32) respectively.

مالوندايالديهايد هو احد المركبات ذات الوزن الجزيئي الواطيء والناتج النهائي لعملية مافوق الاكسدة للدهون ويعتبر كدليل لاكسدة الدهون أما حامض اليوريك فانه يعمل بشكل متناقض كمؤكسد وكمضاد للأكسدة داخل خلايا الجسم. الهدف من البحث هو تقدير مالوندايالديهايد وحامض اليوريك في مصل دم المدخنين وغير المدخنين. تم أجراء البحث بين فترة كانون الثاني الى تموز 2012 على (30) من المدخنين و(30) غير المدخنين.وتم قياس مستوى مالوندايالديهايد في المصل بواسطة جهاز (spectrophotometer) بأستخدام طريقة (thiobarbituric acid) وقياس حامض اليوريك في مصل الدم بأستخدام الطريقة اللونية (colorimetric). أثبتت نتائج البحث على أن الزيادة في قيمة حامض اليوريك في المدخنين عالية معنوياً مقارنةً بغير المدخنين (6.54 ± 0.37 Vs 4.68 ± 0.22) على التوالي. وأما الزيادة في قيمة مالوندايالديهايد ليس معنوية في المدخنين مقارنةً بغير المدخنين (2.227 ± 0.394 Vs 1.912 ± 0.32) على التوالي.

Keywords

Smoking --- MDA --- Uric acid.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

Arabic and English (1)

English (1)


Year
From To Submit

2014 (2)