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Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis
تأثير علاج اللثة غير الجراحي على مستويات TNF-α في مصل المرضى الذين يعانون من التهاب اللثة المزمن

Authors: Haween T. Nanakaly --- Sazan Sartip Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1167-1174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية


Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash).Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjectsat baseline and four weeks after scaling and root planning treatment were quantified fortumor necrosis factor-α levels using ELISA technique.Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed.Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.

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