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Article
Phagocytic Index in Patients with Visceral Leishmaniasis in Iraq

Author: Shahlaa Mahdi Salih
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 2 Pages: 135-140
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Visceral Leishmaniasis is an endemic protozoal disease in Iraq. Recovery from this disease confers a solid and permanent immunity. Immunological assessment of our patients was carried out and the results showed that a significant increase in phagocytic index in patients with VL in comparison with control group.AIM OF THE STUDY: Determining phagocytic index.METHODS:Blood samples were collected from 50 patients suffering from VL confirmed parasitologically by bone marrow smears, 40 blood samples from apparently healthy children and 50 blood samples from children in an endemic area (Al-Suwaira district).Their age was less than six years in all groups, and who were apparently healthy.RESULTS:The immunological assessment of our patients was carried out and the result showed that a significant increase in phagocytic index in patients with Visceral Leishmaniasis in comparison with control group (p<0.01). While the result of endemic control group by ELISA, IFAT and IC were used to test 50 serum samples from healthy children who lived in an endemic area. A total of 48 cases of them were found to be negative at least by one of the above tests, IC showed the lowest cross reactivity rate (4%).CONCLUSION:Phagocytic index was higher in patients with Visceral Leishmaniasis in comparison with control group.


Article
Effect of probiotic Saccharomyces boulardii in weight losing and cytokines levels in mice before and after Infection by Salmonella typhimurium
تأثير المعزز الحيوي Saccharomyces boulardii في فقدان الوزن ومستويات السايتوكينات في الفئران قبل وبعد الإصابة ببكتريا Salmonella typhimurium

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Abstract

This study was designed to evaluate some immunological and nutritional effects of three types of Sacchromyces boulardii yeasts, which was, Mutant Iraqi Isolate (Mutant Saccharomyces boulardii) MSb, commercial strain (Commercial Saccharomyces boulardii) CSb and Local Iraqi Isolate (Local Saccharomyces boulardii) LSb, in the weight and the level of both interleukin-10 (IL-10), interferon-gamma (IFN-γ) in the mice orally administered with yeasts inoculum for 30 days before and after infected with Salmonella typhimurium. The results shown significant losing in the weights and significant increase in the level of IL-10, but there are no significant difference in the levels of IFN-γ at )P>0.05) in mice administered with MSb, CSb and LSb yeasts before infected with S. typhimurium. The results also shown significant difference in the weights, significant increase in the level of IL-10 and significant decrease in the level of IFN-γ at )P>0.05) in mice administered with MSb, CSb and LSb yeasts after infected with S. typhimurium. Despite the effectiveness of three species of yeasts in these parameters before and after infection, but MSb was the most efficiency

أجريت هذه الدراسة لتقييم بعض التأثيرات التغذوية والمناعية لثلاث أنواع من المعزز الحيوي Saccharomyces boulardii وهي كلا من العزلة العراقية المحلية المطفرة MSb (Mutant Saccharomyces boulardii) والسلالة التجارية CSb (Commercial Saccharomyces boulardii) والعزلة العراقية المحلية LSb (Local Saccharomyces boulardii) في معدل الأوزان ومستوى السايتوكينات المناعيين IL-10 وIFN-γ للفئران المجرعة باللقاح اللبني للخمائر أعلاه لمدة ثلاثون يوما قبل وبعد الإصابة بالخلايا الحية للبكتريا المرضية Salmonella typhimurium. أظهرت النتائج حدوث نقصان معنوي (P˂0.05) في معدل أوزان الفئران وزيادة في مستوى السايتوكين IL-10 في حين لم تسجل فروقات معنوية في مستوى السايتوكين IFN-γ في الفئران المجرعة بخمائر MSb وCSb وLSb قبل الإصابة ببكترياS. typhimurium. فيما أظهرت النتائج وجود فروقات معنوية (P˂0.05) في معدل الأوزان وزيادة معنوية في مستوى IL-10وحدوث نقصان معنوي في مستوى IFN-γ في الفئران المجرعة بخمائر MSb و CSbوLSb بعد الإصابة ببكتريا S. typhimurium. رغم كفاءة الخمائر الثلاثة في المؤشرات التغذوية والمناعية المشار إليها قبل وبعد الإصابة ببكتريا S. typhimurium، إلا أن الخميرة المطفرة كانت الاكفا

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