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Article
Determination of Calcium and Iron in Prostate and Bladder Tumors by Atomic Absorption Spectrophotometer
تقدير الكالسيوم والحديد في أورام البروستاتا والمثانة بواسطة مقياس الطيف الامتصاص الذري

Author: Shatha Rouf Moustafa
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 3 Pages: 47-52
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Serum calcium and iron were used as a biochemical markers for investigation of the neoplastic diseases ,since there is a growing concern about the possible links between these minerals and tumors of various organs and tissues ,the objectives of this study were to determine the changes in the serum levels of Ca & Fe ions in patients with benign prostatic hyperplasia and bladder cancer and to identify the role of these markers in diagnosis and prognosis of these patients .METHODS: This study was done in Baghdad at Al-Kadhemia Teaching Hospital between 10/9/2002 and 1/9/2003 .Serum samples were obtained for measurement of calcium and iron.,which were determined by flame atomic absorption spectrophotometer .RESULT Hypercalcemia affects up to 30% of patients with bladder and prostate cancers. In addition there were a decrease in the iron serum level as a result of tumor growth .CONCLUSIONS: Hypercalcemia, is one of the most common metabolic disorders accompanying neoplasia.The cancers most often associated with hypercalcemia, in addition there were a reduction in serum level of iron this biochemical marker may be associated with the pathogenesis of cancer.


Article
Relationship of some ultra trace elements with atherosclerosis

Author: Shatha Rouf Moustafa
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 1 Pages: 66-73
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Trace elements are now measured as possibly having an important role in the pathogenesis of atherosclerosis. This study aimed to investigate the serum rubidium, rhenium, cesium, and boron levels in patients with atherosclerosis as compared with the control group as well as to detect the effect of age and gender and estimate the correlation among the parameters.Methods: This case-control study included 40 patients and 40 apparently healthy adults matched age and gender as a control group. Serum parameter levels were estimated using atomic absorption spectrophotometer.Results: The data of the current study indicated that the levels of rubidium and boron were significantly reduced and there was a significant elevation in the serum level of rhenium while there was no statistical difference in the level of cesium in patients as compared with the control group. In addition, the effect of age and gender did not reveal any significant effect on the serum studied ultra-trace elements levels. There was a negative significant weak correlation between age and Rb (r = -0.38, P = 0.016).Conclusion: Boron and rubidium were significantly reduced; therefore, supplementation could be important for therapy of atherosclerosis.

Keywords

Atherosclerosis --- Boron --- Cesium --- Rhenium --- Rubidium


Article
Biochemical Estimation of Trace Elements Manganese (Mn), Cobalt (Co),Calcium(Ca) and Iron(Fe) in Patients with Cardiovascular Diseases
التقدير الكيموحيوي للعناصر النزرة المغنيسيوم والكوبلت والكالسيوم والحديد في مرضى العضلات القلبية

Author: Shatha Rouf Moustafa شذى رؤوف مصطفى
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2011 Volume: 16 Issue: 4 Pages: 118-123
Publisher: Tikrit University جامعة تكريت

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Abstract

background and objectives : Recent scientific interest has focused on abnormalities in mineral metabolism and those abnormalities may play a role in the pathogenesis of cardiovascular diseases . The hypothesis that trace element status influences the risk of adverse clinical outcomes is worthy of investigation.Therefore, we performed this study on the basis of the existing hypothesis that serum level of Mn,Co,Ca.Fe were inversely associated with prevalence of cardiovascular diseases in 40 patients (20 with hypertension,20 with myocardial infarction), to confirm this possible associations compared with control group (N= 25) , study the sex-effect on the level of these trace elements..Methods:This study was done at college of pharmacy/ Hawler Medical University in period between 15/1/2010 – 20 /12 /2010and the concentrations of studied parameters were measured by atomic absorption spectrophotometer in Baghdad / at Ministry of Science and Technology.Results:The serum values of Mn, Co, Ca ,Fe in patients group were 0.0113 ug/ml±0.00070, 0.012 ± 0.0014 , 61.4118±10.16 , 0.6721± 0.14956 respectively, compared with the control group , 0.025±0.0032, 0.03 ±0.02 , 90±11 , 1.1±0.12 respectively.The results were significantly decreased in patients group as compared with the control group P<0.001. CONCLUSIONS: There were a significant decreased in the studied parameters of patients with CVD.Keywords: Trace Elements

ركزت الاهتمامات االعلمية حديثا على دور العناصر النزرة لحدوث الكثير من الامراض ومنها امراض القلب والاوعية الدموية . لقد وجدت الدراسة الحالية ان هناك علاقة عكسية بين تركيز الدم للعناصر الاتية Mn, Co, Ca, Fe فى الدم وحدوث امراض القلب والاوعية الدموية فى مجموعة مرضى عددهم 40 مريض اعمارهم بين (45 -67) من كلا الجنسين. , 20 مريض منهم مصاب بارتفاع ضغط الدم و20 مريض مصاب باحتشاء العضلة القلبية ومقارنة النتائج مع المجموعة الضابطة (25 شخص طبيعى خالى من الامراض) ومن الاهداف الاخرى لهذه الدراسة , معرفة تاثير الجنس على تركيزالعناصرالنزرةاعلاه فى الدم , ومعرفة الفرق بين ارتفاع ضغط الدم ومرض احتشاء العضلة القلبية فيما يتعلق بتركيز تلك العناصر.حيث كانت تركيز العناصر الاتية Mn, Co, Ca, Fe فى الدم للاشخاص المصابين بامراض القلب والاوعية الدموية على التوالى0.0113 ug/ml±0.00070, 0.012 ± 0.0014 , 61.4118±10.16 , 0.6721± 0.14956 اما تركيز تلك العناصر للمجموعة الضابطة فهى على التوالى 0.025±0.0032, 0.03 ±0.02 , 90±11 , 1.1±0.12هناك فرق احصائى ملحوض بين كلا المجموعتين P<0.001اما تركيز تلك العناصر لمجموعة المصابين بارتفاع ضغط الدم فهى على التوالى 0.01150±00083 , 0.0124±0.00168, 70.1765 ± 4.73333 , 0.81220± 08135بينما تركيز تلك العناصر لمجموعة المصابين بمرض احتشاء العضلة القلبية فهى على التوالى0.0112±0.00054 , 0.0116±0.00096 , 52.6471±5.25525 , 0.5460 ±0.04795

Keywords


Article
The potential role of malondialdehyde, glutathione peroxidase, and interleukin-18 in the development of essential hypertension
الدور المحتمل لمادة malondialdehyde و glutathione peroxidase و interleukin-18 في الاصابة بارتفاع ضغط الدم الأساسي

Authors: Shatha Rouf Moustafa --- Salar Fatih Kudhur
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 2 Pages: 227-237
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objectives: The oxidative stress and inflammatory process are cooperative events involved in the development of essential hypertension. This study was as a step for elucidating the contribution of the malondialdehyde, glutathione peroxidase, interleukin -18 and lipid profile with the development of essential hypertension. This study aimed to assess whether the variation in serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels were associated with the development of essential hypertension, moreover, find out the effect of age, gender and stage on the serum focused parameters levels and finally detect the correlation coefficient.Methods: This case-control study was performed at the College of Pharmacy, Hawler Medical University in newly diagnosed and untreated patients with essential hypertension of both genders, and 50 of the matched age–gender healthy adults as a control group in the period between 2013-2014.Results: Patients exhibited a significant elevation in the serum malondialdehyde, glutathione peroxidase, interleukin-18 and lipid profile levels.Conclusion: This investigation provided for the first evidence the ability of selected parameters in combination patterns as factors involved in essential hypertension pathophysiology and are regarded as markers of diagnostic significance. The demonstration of these parameters provided new insights into understanding the independence of antioxidant status and inflammatory pathways in essential hypertension development.


Article
The role of some oxidative stress and inflammatory factors in essential hypertension
دور بعض الضغوط المؤكسدة والعوامل الالتهابية في ارتفاع ضغط الدم الأساسي

Authors: Shatha Rouf Moustafa --- Julian Yonan Ismaeil
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 1 Pages: 32-40
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objective: Oxidative stress and inflammation are cooperative events involved in essential hypertension development. This study aimed to evaluate the association of N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine with the essential hypertension, detect the effect of other confounding factors like the stage of the disease and gender, and estimate the correlation between the selected parameters.Methods: This case-control study was performed at College of Pharmacy, Hawler Medical University on 50 hypertensive patients of both genders with essential hypertension as well as 45 matched age–gender adults were also enrolled in this study as a control group. The selected parameters were analyzed using ELISA technique.Results: There was a significant elevation in the serum levels of N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine in patients with essential hypertension as compared with the controls. The mean serum levels N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine were increased significantly according to the stage progression of the disease P ˂0.001. No gender effects could be found.Conclusion: Data suggested an association between circulating biomarkers (NT-proBNP, MMP -9, 8-oxo-2-dG) with the development of essential hypertension, there was a significant elevations in the serum selected parameters level in patients as compared with the control group.

Keywords

EHT --- NT-proBNP --- MMP -9 --- 8-oxo-2-dG


Article
Combination of novel and tradition biomarkers to enhance diagnostic sensitivity and specificity for early diagnosis of rheumatoid arthritis and seronegative rheumatoid arthritis

Authors: Shatha Rouf Moustafa --- Evar Ali Taha
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 2 Pages: 247-258
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Rheumatoid arthritis is an autoimmune disease. This study investigated the potential value of combining cartilage oligometric matrix protein, anti-cyclic citrullinated protein, and 14-3-3 eta protein with traditional biomarkers to reduce the diagnostic gap. Methods: This case-control study included 46 male and female patients and 42 age- and gender-matched adults as control group. The biomarkers were measured using ELISA technique.Results: Tests for anti-cyclic citrullinated protein and cartilage oligometric matrix protein are excellent tools to diagnose rheumatoid arthritis because anti-cyclic citrullinated protein and cartilage oligometric matrix protein are associated with the highest ROC area. The validity of the test for 14-3-3 eta protein, which is a good test to predict rheumatoid arthritis, ranks second. The optimum cut-off values for high cartilage oligometric matrix protein, high anti-cyclic citrullinated protein, and high 14-3-3 eta protein were ≥0.242µg/L, ≥0.566ng/L, and ≥0.145ng/L, respectively. 14-3-3η protein, cartilage oligometric matrix protein status as a parallel combination which is considered as a wonderful combination in classification criteria for rheumatoid arthritis. Parallel combination, both criteria two tests are positive, namely “high cartilage oligometric matrix protein (≥0.242) + high 14-3-3η protein (≥0.145)” was associated with a perfect test, that the patients have rheumatoid arthritis (sensitivity 100%, specificity 100%, accuracy 100%, positive predictive value at pre-test probability 50% and 90% = 100%). A positive test using this combination is 100% diagnostic and establishes a possible diagnosis of rheumatoid arthritis with 100%, while a negative test would exclude a possible diagnosis of rheumatoid arthritis with 100% confidence. Conclusion: Results confirmed that high serum level of cartilage oligometric matrix protein, anti-cyclic citrullinated protein, and 14-3-3 eta protein are significantly associated with increased risk for rheumatoid arthritis, demonstrating the potential value of combining these new biomarkers with traditional biomarkers to enhance diagnostic sensitivity and specificity and ultimately reduce the diagnostic gap.


Article
Relations of Trace and Major Elements with Cardiovascular Diseases

Authors: Shatha Rouf Moustafa شذى رؤوف مصطفى --- Sanna Al-Ghadhban --- Showan D. Husain
Journal: Iraqi National Journal Of Chemistry المجلة العراقية الوطنية لعلوم الكيمياء ISSN: 22236686 Year: 2011 Issue: 43 Pages: 436-446
Publisher: Babylon University جامعة بابل

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Abstract

Abstract Back ground and objective: Considerable research has been directed towards the associations between Zn,Cu, Mg & the incidence of CVD in 40 patients aged 45–67 y of both sexes,the objectives of this study were to measure the levels of selected parameters in patients group and compared with 25 apparently healthy adults as a control group , furthermore , compared between patient groups MI N= 20 ,HT N = 20, find –out the sex effect, in addition, evaluate the correlation between these elements. METHODS:This study was performed at College of Pharmacy/ Hawler Medical University in period between 15/1/2010 - 30/10/2010 the studied parameters were measured by atomic absorption spectrophotometer in Baghdad /Ministry of Science and Technology /Department Researches of Chemistry. RESULTS :The results of the patients group were Zn=0.54 ug/ml±0.13,Cu= 0.78ug/ml ±030 ,Mg=11.67±2.12 as compared with the control group ,their results were Zn= 0.745 ± 0.14 ,Cu= 0.96± 0.004, Mg= 18 ±3.The results of this study were statistically significantly decreased in patients group as compared with the control group P<0.001. CONCLUSIONS: There were a statistical significant decrease in the studied parameters in patient groups as compared with the control group P<0.001.

الخلاصة توجة اهتمام البحث الى العلاقة بين تراكيزالقصدير,النحاس والمغنيسيوم فى الدم وحدوث امراض القلب والاوعييه الدموية على40 مريض مقسم الى مجموعتين 20 مريض مصاب بارتفاع الضغط , و20 مريض مصاب بتلف العضلة القلبية اعمارهم بين (45 -67)من كلا الجنسين.اهداف البحث هى قياس هذه العناصر فى الدم ومقارنتها مع المجموعة الضابطة , دراسة الفرق بين الجنسين بالنسبة الى تراكيز هذه العناصر فى الدم , بالاضافه الى دراسة العلاقة بين هذه العناصر,واخيرا دراسة الفرق بين المجموعتين من المرضى فيما يتعلق بتراكيز هذه العناصر فى الدم . انجزت هذه الدراسة فى كلية الصيدلة / جامعة اربيل الطبية للفترة ما بين 15/1/2010 -30/10/2010 , بينما تمت اجراء الفحوصات فى وزارة العلوم والتكلنوجيا / قسم بحوث الكيمياء واجريت الفحوصات باستعمال جهاز Atomic Absorption spectrophotometer اما فيما يتعلق بالنتائج فهى :Zn= 0.54 ± 0.13 Cu = 0.78±0.3, Mg=11.67±2.12 ug/ml , بينما كانت نتائج المجموعة الضابطة Zn=0.745±0.14 , Cu= 0.96±0.004 , Mg=18±3 . ان الدراسة الاحصائية بينت ان هناك فروقات احصائية واضحة بين المجموعتين المرضى والمجموعة الضابطة P<0.001.

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