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Article
Synthesis and Evaluation the Activity of 1, 3, 4-Thiadiazole Derivatives as Antibacterial Agent Against Common Pathogenic Bacteria

Authors: Asmaa Easa Mahmood --- Alaa Adnan Rashad --- Shaymaa Naji Daham --- Evon Akram
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 1 Pages: 25-32
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Schiff base compound 5-(benzylideneamino)-1,3,4-thiadiazole-2-thiol was prepared from condensation reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with benzaldehyde. Schiff bases react with Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ) to form four complexes. The Schiff base complexes were identification by using FTIR and UV-VIS. The antibacterial activity of complexes (Copper(ӀӀ), Ferric(ӀӀӀ), Cobalt(ӀӀ) and Zinc(ӀӀ)) were studied against S. aureus and S . epidermidis as a model of Gram positive, E. coli, P. mirabilis, C. freundii and P. aeruginosa as a Gram negative model to determine activity of synthesized complexes, after subjected them to some tests to confirm the identity of the pathogenic bacteria. Ten antibiotics (Ampicillin and Amoxicillin) have been chosen to investigate the ability of bacterial isolates to resistant the conventional antibiotic. Imipenem have been selected to contrast its efficiency with those of the new compounds because of its high efficiency. The results exhibited higher activity of the new compounds proportional to the chosen antibiotics.

Keywords

Synthesis --- 1 --- 3 --- 4-thiadiazole --- antibiotic --- antibacterial.


Article
Isolations and Identification of bacteria present in the fluids Save contact lenses used by some students girls of the Tikrit University
عزل وتشخيص البكتريا المتواجدة في سائل حفظ العدسات اللاصقة المستخدمة من قبل بعض طالبات جامعة تكريت

Authors: Shaymaa Naji Daham شيماء ناجي دحام --- Hayfaa Rajab Alwan هيفاء رجب علوان --- Hind Tariq Hamed هند طارق حمد
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2016 Volume: 21 Issue: 7 Pages: 72-77
Publisher: Tikrit University جامعة تكريت

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Abstract

The number of people who wear contact lenses (CLS) has been especially increased in the past decade as an alternative to glasses, but many of them do not realize the extent of the hazards involved, and these risks Keratitis associated with microbial causes, so this study included isolation and identification the bacteria in fluids save to lenses with 42 users of contact lenses of students in inner section in the Tikrit University. The study showed the presence of different bacterial groups in the fluids keeping contact lenses which included Staph. epidermis with percentage 30.30% and Staph. Aureuswith percentage 21.21% and the bacteria Streptococcus pneumonia precentage 18.18% and also was diagnosed with Pseudomonas aeruginosa and with 9.09%, while the intestinal bacteria Serratia odorfera where it was obtained with 6.06%. As for the sensitivity of the bacterial isolates to antibiotics, the study proved that more antibiotic effect on gram positive and negative bacteria is erythromycin followed by chloramphenicol while more antibiotic resistance by bacteria is ezithromycin, due to the erroneous and excessive use of these drugs by people.

ان عدد الأشخاص الذين يرتدون العدسات اللاصقة (CLS)قد ازداد خاصة في العقد الاخير وذلك كبديل للنظارات, ولكن العديد منهم لا يدركون مدى المخاطر الناجمة عنها ومن هذه المخاطر التهاب القرنية المرتبط بأسباب ميكروبية، لذا تضمنت هذه الدراسة عزل وتشخيص الجراثيم في سوائل حفظ العدسات اللاصقة لدى 42 من مستخدمين العدسات اللاصقة من طالبات القسم الداخلي في جامعة تكريت. أذ بينت الدراسة وجود مجاميع بكتيرية مختلفة في سوائل حفظ العدسات اللاصقة حيث شملت انواع من بكتريا المكورات العنقودية Staph.epidermis بنسبة30.30 % و Staph. aureus بنسبة21.21% وبكتريا Streptococcus pneumoniae بنسبة 18.18% وكذلك تم تشخيص بكتريا Pseudomonas aeruginosa وبنسبة 9.09% اما بكتريا Serratia odorfera المعوية حيث تم الحصول عليها بنسبة 6.06%. اما فيما يخص حساسية العزلات البكتيرية للمضادات الحيوية قد بينت الدراسة ان اكثر المضادات تأثيرا على البكتريا الموجبة والسالبة لصبغة كرام هيerythromycin ثم يليه chloramphenicol بينما اكثر المضادات مقاومة من قبل البكتريا هو azithromycin وذلك بسبب الاستخدام الخاطئ والمفرط لهذه العقاقير من قبل الناس.

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