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Article
Postprandial lipid profile and Androgen status in polycystic ovarian syndrome (PCOS)

Authors: Thuraya abdulla H. --- Ghassan A. Al-Shamma --- Shaymaa Z. Al-Saedi*,
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 1 Pages: 1497-1505
Publisher: Kerbala University جامعة كربلاء

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Abstract

objective:Immunofluorescent microscopyis an important tool for the diagnosis of glomerular diseases. In this study, we focused on using IF technique together with light microscopy and clinical features in the diagnosis of different types of glomerulonephritis. Spectrum of glomerular disease in Iraq is to be studied and compared with other studies in Iraq and other countries.Methods:A total of 58 kidney biopsies were taken for routine LM, while IF technique was done in 56 of them. The study started from 1st of June 2010 to the 1st of June 2012.Results:Focal segmental glomerulosclerosis(17/58=29.3%) topped thelist followed by minimal change disease(12/58=20.7%).Immunedeposition wasobserved in (21/56=37.5%)cases and the predominant depositwas immunoglobulin G(20/56=35.7%).The pattern ofdeposition was granular in most of the cases either in the glomerular basement membrane and/or in the mesangium except one case where immunoflourecent microscopy showed dominant positive staining (3+) for complement factor 1q in the glomerular mesangium and slightly positive staining for complement factor 3 in the same mesangealareas.(Tow/58=3.4%) cases fulfilled the clinical, serological andhistopathological criteria of lupus nephritis.Conclusion:To obtain a correct diagnosis of glomerulonephritis, we require immunofourescent in parallel with light microscopic examination of renal biopsies and correlation with clinical features, biochemical and serological markers. Clinically, the majority of patients presentedas nephrotic syndrome (44/58=75.9%).Key words: Immunofluorescence,glomerular disease.


Article
POSTPRANDIAL TRIGLYCERIDE AND TESTOSTERONE IN WOMEN WITH CARDIOVASCULAR DISEASES

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Abstract

Background : High androgen levels may increase cardiovascular disease (CVD) risk in women through adverse effects on lipids, blood pressure, and glucose metabolism. Lipid abnormalitiesare often found in women with CVD.Objective:To study the relationship between postprandial triglycerides (TG) as a risk factor for cardiac disease and the androgenic activity in postmenopausal women with CVD.Methods:Postprandial lipid profile and sex hormone levels were measured in 30 patients with CVD and 25 postmenopausal women age and body mass Index (BMI) matched served as control group.Testosterone and sex hormone binding globulin (SHBG), Estradiol (E2), follicular stimulating hormone (FSH) and luteinizing hormone (LH) were estimated.Results:Postprandial TG, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and atherogenic index (AI) were different between the two groups (P≤0.001). The SHBG and Free Androgenic Index (FAI) were significantly higher in the CVD postmenopausal women (P≤ 0.001) while no differences in testosterone, LH, FSH, and E2 levels noticed between CVD patients and the control group. Serum testosterone levels correlated positively with the postprandial TG and the atherogenic index, and negatively with HDL-C in the CVD patients.Conclusion:Elevation in androgenic activity could be a cause of higher elevation in postprandial serum TG which may increase the risk of CVD in women.Key Words:postmenopausal women, cardiovascular disease, postprandial lipid profile, testosterone, sex hormone binding globulin, free androgenic index

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