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Salivary alkaline phosphatase and acid phosphatase levels in gingivitis diagnosis and treatment
مستويات الفوسفاتيز القلوية اللعابية وحمض الفوسفاتيز الحمضي في تشخيص وعلاج التهاب اللثة

Authors: Bakhtiar Mohiadeen Ahmed --- Sherzad Abdul-Rahman
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 2 Pages: 726-731
Publisher: Hawler Medical Univeristy جامعة هولير الطبية


Background and objective: Gingivitis is the presence of clinical signs of inflammation in gingiva and is associated with teeth showing no attachment loss. Human saliva contains informative components that can be used as diagnostic markers for human diseases. This study is directed to evaluate salivary phosphatase enzymes levels in diagnosis and follow up the treatment of gingivitis.Methods: Saliva samples were collected from 100 healthy persons, and 50 patients before treatment (scaling and polishing) and 20 days after the treatment. Their age ranged between 20-30 years. Alkaline phosphatase and acid phosphatase activities, some kinetics and thermodynamic parameters were measured.Results: Salivary alkaline phosphatase and acid phosphatase activities elevated in gingivitis, while their levels returned to the control values after treatment. The Michaelis constant (Km) values for salivary alkaline phosphatase and acid phosphatase decreased in gingivitis, while the maximum velocity (Vmax) values increased. These values returned back to normal values after treatment. The changes in the thermodynamic parameters (∆H*, ∆G* and ∆S*) values of transition state for salivary alkaline phosphatase were non-significant, while their changes were significant for salivary acid phosphatase, except for ∆G* value.Conclusion: Salivary alkaline phosphatase and acid phosphatase levels can be relevant for diagnosis and the follow-up of gingivitis treatment.

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