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•Immunohistochemical Cytokeratine 20 over expression in urinary bladder carcinoma

Authors: Shoroq Mohammad Abbas Al-Temimi --- Maather Baqer Hussein Al-Harmoosh
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 2 Issue: 10 Pages: 1077-1083
Publisher: Kerbala University جامعة كربلاء

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Abstract

this study was conducted to estimate the over expression of CK 20 protein in human bladder carcinoma (transitional cell carcinoma in comparison to squamous cell carcinoma) and to show its possible correlation to the pathological parameters (gradeand stage) of TCC cases . We evaluated the available tissue blocks of 50 patients with bladder carcinoma lesions (40 with TCC & 10 cases with SCC) who had referred to Al-diwaniya Hospital between January 2007 and December 2010.The mean age of the patients was 55 years (range, 33 to 77 years). The TCC were classified according to grades into grade I, II and III in 20 (50%), 10 (25%), and 10 (25%) cases, respectively and according to stages into Ta in 10 (25%), T1 in 10(25%), T2 in 10(25%) and T3 in 10(25%). From 40 cases of TCC, A total of 28 (70%) patients were positive for over expression of CK20 and no expression were found in cases SCC. High histological grades of the TCC were associated with decrease expression of CK 2 .There were 20 (100%) in GI , 5 (50%) in GII , 3 (30%) in GII (P = .0000) while CK20 expression decreased as the tumor stages increased , it was 10 (100%) in Ta , 8 (80%) in T1 , 6 (60%) in T2 , 4 (40%) in T3 , and there is a statistically significant correlation with the stages of TCC of bladder (p=0.0229 ) .Aim of the Study: This study was conducted to estimate the over expression of CK-20 protein in human bladder TCC in comparison to bladder SCC lesions and to show its possible correlation to the pathological parameters of TCC like (grade and stage) .Key ward: - Bladder TCC, Bladder SCC, Cytokeratin 20, IHC

Keywords

Bladder TCC --- Bladder SCC --- Cytokeratin 20 --- IHC


Article
Immunohistochemical study of HER-2 /neu in invasive ductal carcinoma of breast
.

Authors: Maather Baqer Hussein Al-Harmooshy مأثر باقر حسين --- Shoroq Mohammad Abbas Al-Temimi شروق محمد عباس
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2011 Volume: 7 Issue: 11 Pages: 95-105
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Abstract
This study was conducted to estimate the overexpression of HER-2eu protein in human breast carcinoma in comparison to benign breast lesions and to show its possible correlation to the pathological parameters (histological type, grade and age). We evaluated the available tissue blocks of 50 patients with breast lesions (38 with invasive ductal carcinoma & 5 cases with fibroadenoma , 5 cases with fibrocystic disease & 2 cases with normal tissue) who had referred to Al-diwaniya Hospital between January 2007 and December 2010 All cases were female.
The mean age of the patients was 55 years (range, 33 to 77 years). The tumors were grade 1, 2, and 3 in 6 (15.7%), 19 (50%), and 13 (34.3%) cases, respectively. From 38 cases of IDC , A total of 12 (31.5%) patients were positive for overexpression of HER- 2/neu oncogene and From 12 cases of non malignant cases all of them were negative for overexpression of HER- 2/neu oncogene . The positive cases was with strong positive 3+ in 21.2% and in score 1 and 2 in 5.2% . High histologic grades of the breast IDC were associated with increased expression of HER-2/neu. There were 2 cases of HER-2/neu-positive (16.6%) with a grade 1 tumor, 4 (33.4%) with grade 2, and (50%) with grade 3 (P = .002 .There was a significant difference in HER-2/neu overexpression with the invasive ductal carcinoma and but no correlation was detected between HER-2/neu overexpression and the patient’s age.
Aim of the Study: This study was conducted to estimate the overexpression of HER-2eu protein in human breast carcinoma in comparison to benign breast lesions and to show its possible correlation to the pathological parameters ( grade and age) .

يهدف البحث إلى دراسة التعبير المناعي النسيجي الكيميائي لجين أل HER-2/neu كمؤشر للتغيرات الجينية الطارئة في ألخلايا السرطانية لأورام الثدي ومقارنته في النسيج الحميد ولمعرفة ترابط هذا التغير مع ثوابت أخرى مثل عمر المريض و درجة تمايز الورم. تمت دراسة 50 عينة من عقدة الثدي في مختبرات مستشفى الديوانية التعليمي للفترة منذ بداية كانون الثاني 2007 وحتى كانون الاول 2010 , تم جمع 38 عينة من مرضى مصابين بسرطان الثدي و12 عينة من ورم الثدي الحميد , تراوحت أعمارهم بين 33 و 70 سنه مع معدل عمر 55 سنه ،وقد قورنت المجموعتان مع بعض. أظهرت الدراسة المناعية النسيجية أن تعبير أل- HER-2/neu كان موجبا في 31.5% من سرطان الثدي, ولا يوجد تعبير في عينات الورم الحميد .كان تعبير ال- HER-2/neu أكثر في المرضى ضمن مجموعة العمر الأكبر من خمسين عاما , في الأورام ذات التمايز الضعيف(الدرجة الثالثة ) عنه في الأورام ذات التمايز القوي والمتوسط (الدرجة الأولى والثانية ).مع عدم وجود ترابط بين التعبير المناعي النسيجي ا ل- HER-2/neu مع العمر (قيمة ألفا > 0.05) كما انه توجد علاقة واضحة لتعبير ا ل- HER-2/neu مع درجة التمايز ( قيمة ألفا < 0.05). مما يدل على ان جين أل-HER-2/neu يلعب دور أساسي في تقييم حالة سرطان الثدي المستقبلية وانتشاره وتحديد أهمية الاستجابة للعلاج .

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