research centers


Search results: Found 4

Listing 1 - 4 of 4
Sort by

Article
Effects of simvastatin on lipid profile, atherogenic index and serum transaminases in hyperlipidemic patients
آثار سيمفاستاتين على البروتين الدهني ومؤشر تصلب الشرايين و مصل transaminases في مرضى شحميات الدم

Authors: Ari Aziz Salih --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2011 Volume: 15 Issue: 2 Pages: 29-33
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Hyperlipidemia is characterized by increased concentrations of lipids including triglycerides, total cholesterol, low density lipoproteins, very low density lipoproteins in the blood and some times decreased high density lipoproteins .Many drugs have been used for treatment of this disorder. The present study was designed to estimate the effects of simvastatin on lipid profile, atherogenic index, transaminases, creatinine, uric acid and alkaline phosphatase.Methods: This study covered 70 subjects, they were divided into two groups, the first group included 45 hyperlipidaemic patients which were treated with 20mg simvastatin and second group included 25 normal subjects. After 12 hours fasting, serum lipid profile, transaminases; alkaline phosphatase, uric acid and creatinine were measured for the patients in 3 intervals before treatment, after 8 weeks and 16 weeks of treatment, and one time for normal subjects.Results: : After therapy, simvastatin showed a significant reduction in serum (TC, TG, LDL, VLDL and atherogenic index) and also, significant rise in HDL noticed, by performing a comparison between the group before treatment, and groups after treatment.Serum ALT, AST and ALP were significantly increased but were still within normal levels.Insignificant effect was observed from serum creatinine, uric acid and also body mass index by performing a comparison between group before treatment and groups after treatment.Conclusions:Simvastatin was effective in controlling lipid profile and atherogenic index, with no significant abnormality in liver functions.


Article
Effect of atorvastatin, with or without ezetimibe, on serum lipid profile and ALT in hyperlipidemic patients
تأثير أتورفاستاتين ، مع أو بدون ezetimibe ، على الملف الدهني للدهون و ALT في مرضى شحميات الدم

Authors: Wishyar Abbas Hamad --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2011 Volume: 15 Issue: 1 Pages: 13-19
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Hyperlipidaemia is raised serum levels of one or more of total cholesterol, low-density lipoprotein and triglycerides. Many drugs have been used for the treatment of this disorder. This work compares the effects of atorvastatin with or without ezetimibe on lipid profile, atherogenic index and serum alanine aminotransferase.Methods: This study covers 90 subjects, 60 untreated hyperlipidemic patients, and 30 healthy subjects. Patients were divided into 2 groups, the first group included 30 patients treated with atorvastatin 20 mg/day alone, the second group included 30 patients treated with a combination of 2 drugs (atorvastatin 10 mg plus ezetimibe 10 mg) taken daily at night. Serum lipid profile, atherogenic index and serum alanine amniotransferase were measured after 12 hours fasting for the patients in 3 intervals: before, and after 8 weeks and 16 weeks of treatment.Results: After therapy for both groups of patients, as compared to the levels before treatment, has shown that serum total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein cholesterol were significantly reduced while high density lipoprotein cholesterol was significantly increased. Serum alanine aminotransferase increased by both groups of treatment with no significant difference between the two modes of treatment which has the same findings in comparison to the control group.Conclusion: Combination of atorvastatin 10 mg and ezetimibe 10 mg daily, is more effective than atorvastatin 20 mg taken alone.


Article
Efficacy of simvastatin compared with atorvastatin in patients with hyperlipidaemia in Kurdistan
فعالية سيمفاستاتين مقارنة مع أتورفاستاتين في مرضى فرط شحميات الدم في كردستان

Authors: Ari Aziz Salih --- Wishyar Abbas Hamad --- Showan D. Husain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 2 Pages: 90-97
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Lowering the blood cholesterol and low density lipoprotein levels may reduce the risk of coronary heart disease. This study was designed to evaluate the effect of lipid-lowering therapy by simvastatin 20 mg versus atorvastatin 20mg on patients suffering from hyperlipidemia.Method: This study is 16-weeks duration included 75 patients with hyperlipidemia. Patients were assigned randomly to receive either simvastatin 20 mg/day group (1), or atorvastatin 20 mg/day group (2). After 12 hours fasting, lipid profile, atherogenic index and alanine aminotransferase were assessed for the patients at baseline, 8-weeks and at the end of 16-weeks of treatment.Results: After therapy for both groups of patients, as compared to the levels at the baseline, the serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were significantly reduced while high density lipoprotein cholesterol (HDL-C) was significantly increased. Serum alanine aminotransferase (ALT) increased by both groups of treatment with no significant differences between the two modes of treatment.Conclusion: After treatment with simvastatin 20 mg and atorvastatin 20 mg, there were a reduction in total cholesterol, triglyceride, LDL-C, and VLDL-C, and an increase in HDL-C in both groups. Comparing the two types of treatment, atorvastatin 20 mg was more effective in lowering triglyceride and VLDL-C than simvastatin 20 mg while Simvastatin led to greater reduction in LDL-C. Both modes of treatment were well tolerated by the patients.


Article
Relations of Trace and Major Elements with Cardiovascular Diseases

Authors: Shatha Rouf Moustafa شذى رؤوف مصطفى --- Sanna Al-Ghadhban --- Showan D. Husain
Journal: Iraqi National Journal Of Chemistry المجلة العراقية الوطنية لعلوم الكيمياء ISSN: 22236686 Year: 2011 Issue: 43 Pages: 436-446
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Abstract Back ground and objective: Considerable research has been directed towards the associations between Zn,Cu, Mg & the incidence of CVD in 40 patients aged 45–67 y of both sexes,the objectives of this study were to measure the levels of selected parameters in patients group and compared with 25 apparently healthy adults as a control group , furthermore , compared between patient groups MI N= 20 ,HT N = 20, find –out the sex effect, in addition, evaluate the correlation between these elements. METHODS:This study was performed at College of Pharmacy/ Hawler Medical University in period between 15/1/2010 - 30/10/2010 the studied parameters were measured by atomic absorption spectrophotometer in Baghdad /Ministry of Science and Technology /Department Researches of Chemistry. RESULTS :The results of the patients group were Zn=0.54 ug/ml±0.13,Cu= 0.78ug/ml ±030 ,Mg=11.67±2.12 as compared with the control group ,their results were Zn= 0.745 ± 0.14 ,Cu= 0.96± 0.004, Mg= 18 ±3.The results of this study were statistically significantly decreased in patients group as compared with the control group P<0.001. CONCLUSIONS: There were a statistical significant decrease in the studied parameters in patient groups as compared with the control group P<0.001.

الخلاصة توجة اهتمام البحث الى العلاقة بين تراكيزالقصدير,النحاس والمغنيسيوم فى الدم وحدوث امراض القلب والاوعييه الدموية على40 مريض مقسم الى مجموعتين 20 مريض مصاب بارتفاع الضغط , و20 مريض مصاب بتلف العضلة القلبية اعمارهم بين (45 -67)من كلا الجنسين.اهداف البحث هى قياس هذه العناصر فى الدم ومقارنتها مع المجموعة الضابطة , دراسة الفرق بين الجنسين بالنسبة الى تراكيز هذه العناصر فى الدم , بالاضافه الى دراسة العلاقة بين هذه العناصر,واخيرا دراسة الفرق بين المجموعتين من المرضى فيما يتعلق بتراكيز هذه العناصر فى الدم . انجزت هذه الدراسة فى كلية الصيدلة / جامعة اربيل الطبية للفترة ما بين 15/1/2010 -30/10/2010 , بينما تمت اجراء الفحوصات فى وزارة العلوم والتكلنوجيا / قسم بحوث الكيمياء واجريت الفحوصات باستعمال جهاز Atomic Absorption spectrophotometer اما فيما يتعلق بالنتائج فهى :Zn= 0.54 ± 0.13 Cu = 0.78±0.3, Mg=11.67±2.12 ug/ml , بينما كانت نتائج المجموعة الضابطة Zn=0.745±0.14 , Cu= 0.96±0.004 , Mg=18±3 . ان الدراسة الاحصائية بينت ان هناك فروقات احصائية واضحة بين المجموعتين المرضى والمجموعة الضابطة P<0.001.

Listing 1 - 4 of 4
Sort by
Narrow your search

Resource type

article (4)


Language

English (4)


Year
From To Submit

2012 (1)

2011 (3)