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Significance of Agnor Statuus in Epithelial Salivary Gland Tumors

Authors: Balkees T. Garib --- Suha A. H.Hindi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2005 Volume: 2 Issue: 4 Pages: 379-387
Publisher: Babylon University جامعة بابل


The present retrospective wo* was conducted on epilhelial salivary gland tumo$ (ESCTS) (benign andrnalignant ) anong lmqi patients with the main objective ofchancterizing differenl biological behavio. ofdifferent salivary gland tumors- The AgNOR status was assessed in relation to the cellular activity ofThis study comprised a total of40 patients diagnosed as salivary gland tunors in rhe depadmenr oforal-Pathology at college of Dentistry, Universiq, ofBaghdad.Thjs se es consisted of(18) cases of benig'rtumon and (22) cases ofrnalignant tumors thal affected both major and minof salivaD, glands.The convenlional examinalion revealed that,the 18 cases ofbenign ttrmorc consisted of la cases (i5%)pleonorphic adenoma and 4 cases ( 1 o%)caDalicular adenoma while the (22) cases of malignanl lumo|sconsisted of 9 cases (22.5%) mucoepidermoid carcinona,Scases (20%) aderocystic carcinoma and scases(12.5%) adenocarcinolna.'l'he estimatior of AgNOR status was car ed out on 4 $n tumor secrions using one step silvef stainingtechDique. lhe mean AgNOR count ,was calculaied and the size and distribution of AgNOIt dors wercsubjectively evaluated as fine or lafge aDd grouped, peripheral or scattered respectively. Data demorstrateddrar benign tumoN has less mean AgNOR count (3.61) than malignant lumors ( tlre difiercnceerseen I en, s q,lr .rgnifica.,lResults showed tlat there is significant difTefeDc< beL$ccn pleomoryhi( rderonD ir(l iirll LUlaf adenonra.Malignant iumors sholved significanl differeDce among differ€nt types and irterestingly ther€ js asignificanl diffcrcnce beLwcen two dillbrent gfolr,th pattem ofadenocyslic carcinonra (solid and cribritomEvaluarion ofrhe size and distribLdon ofAgNOR dots within these tumors revealcd ihar benign rumorspresented mainly whh large NORs dots (52-59%),aggrcgated in grouping paftern mainly (67-71%) ,whilemalignant tLrmoN presenied mainly with fine size NoRs(63-68%),distributed in grouping paftern foradenocyslic carcinoma (61%) and mucoepidermoid carcinoma (50%) which is more asgressive .In conclusion our resuirs indicated that AgNOR status is an additio al useful tool in diffefentiation betweeDbengnr and nraligDant ESGTS, and prcdicting lhe degee of aggressiveness of each tLnnof which may a1faclthe pfognosis oflhesc lumors.Fof the best ofour knowledge this is the first study on ESGTS diagnosis, usnrg AgNOR marl(er as indicatorfor aggressiveness and prognosis ofthese tumor


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