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A clinical study evaluating the effect of 0.4% stannous fluoride gel in controlling plaque and gingivitis
دراسة سريرية لتقييم تأثير جل 0,4 % فلوريد القصدير في السيطرة على الصفائح الجرثومية والتهاب اللثة.

Author: Suzan Ali Salman سوزان علي سلمان
Journal: Al-Rafidain University College For Sciences مجلة كلية الرافدين الجامعة للعلوم ISSN: 16816870 Year: 2011 Issue: 28 Pages: 17-30
Publisher: Rafidain University College كلية الرافدين الجامعة

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Abstract

Background: Stannous fluoride is a broad-spectrum antimicrobial agent. It has been incorporated into dentifrice formulations and shown to be effective in the prevention and reduction of gingivitis (17, 18, 20), the aim of the study was to determine whether conventional tooth brushing and twice daily use of a brush on 0.4% stannous fluoride (SnF2) gel would be more effective for controlling plaque accumulation and gingivitis than conventional tooth brushing alone.Materials and Methods: A randomized, six month, single examiner blind. Gingivitis study conducted according to the guide lines for evaluating chemotherapeutic products for the control of gingivitis. 0.4% stannous fluoride gel was tested against a commercially available negative control dentifrice (Crest Complete, KSA). The sample of the study included two groups, the first; control group (N=30) used tooth brushing with standard fluoride tooth paste( Crest Complete ,KSA),while the second; study group (N=30) used tooth brushing with the same tooth paste, supplemented with a 0.4% stannous fluoride gel used twice daily for the entire six month-study period. Clinical assessment involved plaque index(1) gingival index(2) and bleeding on probing index(3) were performed at base line, three and six months post-treatment. Result: The stannous fluoride gel (SnF2) group had highly significant lower scores for plaque index (PL.I, p< 0.01), gingival index (GI, p< 0.01) and bleeding tendency at all examinations than did the control group. For the study group, mean baseline PL.I score was 1.83, at three months it was reduced to 0.84and after six months it was 0.54.For the GI. Mean baseline GI. was 1.60, at three months it was 0.82 and after six months it was reduced to 0.57. Conclusion: It is concluded that the use of 0.4% SnF2 gel is an effective adjunct to mechanical tooth cleaning in decreasing plaque and gingivitis.Key words: Stannous fluoride, plaque, gingivitis.

فلوريد القصدير هومضاد جرثومي واسع الطيف . تم مزجه مع مواد اخرى لتصنيع معاجين اسنان ولوحظ انه فعال في الوقاية والتقليل من التهابات اللثة.( 20,17,18). الهدف من الدراسة لتحديد فيما اذا كان تفريش الاسنان بطريقـة تقليدية او الاستعمال اليومي لهلام او جل فلوريد القصدير سيكون اكثر تأثيرا في السيطرة على تراكم الصفائح الجرثوميةوالتهابات اللثـــــة من الطريقـــــة التقليدية في التفريشالمواد المستعملة وطريقة العمل: الدراسة شملت عينة عشوائية من المرضى المصابين بالتهابات اللثة واستمرت لستة اشهر وتم توزيع لتقييم تأثيرمادة كيميائية علاجية في السيطرةعلى التهابات اللثة .0,4% من جل فلوريد القصدير تمت مقارنته مع معجون اسنان اعتيادي يحتوي على الفلورايد (( Crest Complete ,KSA . الدراسة تضمنت مجموعتين هي المجموعة الضابطة وتكونت من ثلاثين شخصا , وهم اشخاص يستعملون معجون اسنان قياسي يحوي على الفلورايد ( ( Crest Complete ,KSA المجموعة الثانية : وهي المجموعة التجريبية وتكونت من ثلاثين شخصا يستعملون نفس معجون الاسنان القياسي اضافة الى التفريش بجل 0,4% فلوريد القصدير استعمال لمرتين في اليوم ولمدة ستة اشهر الفحص السريري شمل مؤشر الصفيحة الجرثومية(1) ومؤشرالتهابات اللثة (2) ومؤشر النزف عند التسمير(3) تم قياسه في الزيارة الاولى وبعد ثلاثة اشهر وبعد ستة اشهر.النتائج: بالنسبة للاشخاص الذين استعملوا فلوريد القصدير النتائج اظهرت فرقا معنويا كبيرا لمؤشر الصفيحة الجرثومية ولمؤشر التهابات اللثة ولمؤشر النزف عند التسمير عند المقارنة مع المجموعة الضابطة. وكان متوسط الصفيحة الجرثومية في الزيارة الاولى (1,83 )وبعد ثلاثة اشهر اصبحت (0,84) وبعد ستة اشهر كانت (0,54) اما لمتوسط مؤشر التهابات اللثة فكان( 1,60) في الزيارة الاولى وبعد ثلاثة اشهر قل المتوسط ليصبح (0,82) وبعد ستة اشهر اصبحت (0,57) الاستنتاج: ان استعمال 0,4% من جل فلوريد القصدير هو فعال وعامل مساعد للتفريش التقليدي الميكانيكي في تقليل تراكم الصفيحات الجرثومية والتهابات اللثة. الكلمات الدليلة: فلوريد القصدير , الصفائح الجرثومية , التهابات اللثة.


Article
Measurement of salivary Immunoglobulin A of participants with a healthy, gingivitis and chronic periodontitis conditions

Author: Suzan Ali Salman سوزان علي سلمان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 3 Pages: 120-123
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Secretory Immunoglobulin A (SIgA) is a subclass of Immunoglobulin A (IgA), It is an antibody that playsan important role in mucosal immunity. It is the main immunoglobulin found in mucous secretions from mammaryglands, tear glands and salivary glands, every pathologic process in the body involves the immune system, andperiodontal inflammation is one of them and is not an exception.Material and methods: this study was consisted of 60 healthy male participants of an age ranged between (35-50)years old ; 25 of them with generalized moderate chronic periodontists(Clinical Attachment Loss equal to 3-4mm at ≥30% of the sites; 20 participants with plaque induced gingivitis and 15 participants had clinically healthyperiodontium as control group. oral examination include Plaque Index, Gingival Index, Probing Pocket Depth andClinical Attachment Level were conducted for all participants four sites were examined for each tooth (labial,lingual, mesial and distal), 2ml of unstimulated whole saliva was collected from all participants to measureSecretory Immunoglobulin A in μg /ml by Enzyme-linked immunosorbent assay technique.Results: salivary IgA(sIgA) mean was (356.3) μg /ml for the chronic periodontitis patients; while it was 202 μg /ml forplaque induced gingivitis patients and it was 129.2 μg /ml for the control group. Highly significant differencesamong the three group were recorded (P-value <0.001). For chronic periodontitis patients, the Plaque Index GingivalIndex scores were positively highly significant correlated with Secretory Immunoglobulin A level in saliva. The ProbingPocket Depth scores were positively and significantly associated with Secretory Immunoglobulin A level. The ClinicalAttachment Level scores were positively but non significant associated with Secretory Immunoglobulin A level. Forthe gingivitis and the control group they were positive non significant association between the periodontalparameters and the Secretory Immunoglobulin A level in saliva.Conclusion: there is a correlation between Secretory Immunoglobulin A level in saliva and the periodontal healthstatus.


Article
Measurement of serum Superoxide dismutase levels in women with polycystic ovarian syndrome and chronic periodontitis

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Abstract

Background: Polycystic ovarian syndrome (PCOS) is one of the most important reproductive and endocrine disorders in women at reproductive age. It's associated with metabolic disorder, obesity, insulin resistance and oxidative stress chronic periodontitis and PCOS both of them associated with low chronic grade of inflammation. The prevalence of periodontal disease seems to be higher in women with PCOS. Superoxide dismutase enzyme (SOD) is an important circulating marker and protecting enzyme helping the body tissues to get rid of reactive oxygen species (ROS) that damage the tissue. Aim of the study: The aim of this study was to measure and compare the levels of (SOD) among group of chronic periodontitis patients with PCOS, group of chronic periodontitis without PCOS and a third group who were systemically and periodontally healthy. Material and Method: This study consist of (60) women at reproductive age ranged between (25-40) years old. They divided into three groups Group I consist of 20 women systemically healthy and with healthy periodontium, group II consist of 20 women with chronic periodontitis and systemically healthy and Group III consist of 20 women with chronic periodontitis and (PCOS). We evaluated the periodontal health of the groups through measuring these important indices: Plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment loss. SOD antioxidant marker was measured colormeterically for the three groups. Results: this study showed higher means of periodontal parameters (plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment loss (1.275±0.246, 1.295±0.239, 0.24±0.16, 6.47±0.345, 4.125±0.328 respectively). Highly significant differences were found using t-test in inter group comparison. (P≤0.001) regarding pocket depth and clinical attachment loss .Higher mean of (SOD) level was found for G3 (137.72±29.769) U/mL . F-test was used for intragroup comparison and highly significant difference was found (P≤0.001). Positive but weak correlation where found among (SOD) level, bleeding on probing in Group I and Group II , also among (SOD) level, probing pocket depth and clinical attachment loss. Conclusion: (PCOS) associated with oxidative stress and more prone to periodontal diseases with high level of antioxidant agent like (SOD) level to compensate the high level of (ROS)

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