research centers


Search results: Found 3

Listing 1 - 3 of 3
Sort by

Article
Oral manifestations, oral health status and saliva composition changes in a sample of Iraqi systemic lupus erythematosus patients

Authors: Noor S. Mohammed نور محمد --- Taghreed F. Zaidan تغريد زيدان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 65-69
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease associated with significantmorbidity and mortality. Sicca symptoms are frequent in SLE which may be related to concomitant occurrence ofSjögren's syndrome (SS). The aims of study were to determine prevalence of oral manifestations andtempromandibular joint disorders, and to find a correlation between the changes in saliva flow rate, pH andcomposition with the incidence of dental caries in SLE patients.Subjects, materials and methods: One hundred and two individuals were enrolled in this study; 52 of them were SLEpatients; and 50 were healthy control individuals matched in age and gender. The assessment of dental status wasmade according to the decay missing filling teeth (DMFT) index; the gingival inflammation was assessed using thecriteria of gingival index; Clinical pocket depth was measured with periodontal probe type William, and wholeunstimulated saliva samples have been collected from each subject for biochemical analysis. Also, salivary flow rateand pH were measured. After centrifugation, the supernatant of saliva was aspirated for biochemical analysis.Results: Oral ulceration was the most prominent orofacial manifestations of SLE patients followed byTempromandibular joint (TMJ) disorders and facial skin rash then oral vesicles& bullae, oral lichen planus and finallyoral petechiae & purpura. Salivary flow rate and salivary pH were significantly lower in SLE patients than in the controlsubjects. Oral hygiene index (DMFT index, gingival index, Clinical pocket depth) were significantly higher in SLEpatients than in the control subjects .Salivary calcium, sodium, chloride, and total protein were significantly higheramong SLE patients than in the control subjects. While salivary potassium and inorganic phosphorus were significantlylower among SLE patients than in the control subjects. In addition, there was a highly significant positive linearcorrelation between age of SLE patients and DMFT, and between age and clinical pocket depth; and a highlysignificant negative linear correlation between salivary flow rate and salivary calcium in SLE patients. Also there washighly significant positive linear correlation between DMFT and salivary calcium, and between DMFT and salivarychloride.Conclusions: Oral manifestations are common in Iraqi SLE patients. Changes in salivary flow rate, pH, salivarycomposition, and increased dental caries may serve as potential markers of the extent of autoimmune mediatedsalivary gland dysfunction which is similar to Sjogren’s syndrome


Article
Trace elements and oxidative stress markers in saliva of subjects with amalgam fillings

Authors: Huda Sh. Ahmed هدى احمد --- Taghreed F. Zaidan تغريد زيدان --- Ali Yakub علي يعقوب
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: 3 Pages: 63-66
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Amalgam is the most frequently used restorative material for dental treatment. It is mainly used inposterior teeth, usually on occlusal surfaces as an economical, long lasting and durable filling material and representthe main source of exposure to mercury and other toxic metals (copper, tin, silver, etc.).This study designed to measure oxidative stress marker malondialdehyde (MDA) and anti-oxidants (uric acid andglutathione) concentrations in saliva of subjects with amalgam fillings. And measure trace elements (copper, zinc)concentrations in saliva of subjects with amalgam fillings.Subjects,materials and methods: Fifty subjects were participated in this study, they were between the age of (20-50)years with amalgam fillings (cases group) and fifty one subjects with no amalgam fillings (control group), they weregender and age matched to that of subjects with amalgam fillings. Informed consent and ethical approval wasobtained. Each subject fill a case sheet questionnaire then examined by using sterile dental mirror and sterile dentalprobe to determine any oral manifestations and to calculate the number of amalgam filled teeth and the number offilled surfaces.Results: The results obtained from this study showed that Oxidative stress marker (MDA) were increased whileantioxidants (glutathione, uric acid) were decreased in saliva of subjects with amalgam fillings. Trace elements(copper, zinc) were higher in saliva of subjects with amalgam fillings; salivary copper was significantly higher insubjects with > 10 amalgam filled teeth. Salivary total glutathione was significantly correlated (negative correlation)with the number of filled teeth. Salivary copper was significantly correlated (positive correlation) with the number offilled teeth and filled surfaces.Conclusion: This study revealed that amalgam fillings associated with increase in oxidative stress marker(MDA) anddecrease in antioxidants (glutathione, uric acid).Trace elements (copper, zinc) increased in saliva of subjects withamalgam fillings.


Article
Assessment of serum and salivary oxidant and total antioxidant status of patients with recurrent aphthous stomatitis in a sample of Basrah city

Authors: Hussein Sh. Al-Essa حسين العيسى --- Taghreed F. Zaidan تغريد زيدان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: special issue 1 Pages: 83-88
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Recurrent Aphthous Stomatitis (RAS) is the most common painful oral mucosal disease, affectingapproximately 20% of the population. RAS presents with a wide spectrum of severity ranging from a minor nuisanceto complete debility. Many of factors thought to have been involved in its etiology; that might have at the same timea direct or indirect impact upon oxidant/antioxidant system and trigger free radicals production. The aim of thisstudy was to determine the possible association of oxidant/total antioxidant status and recurrent aphthous stomatitis(RAS).Subjects, materials and methods: The study consisted of thirty patients with recurrent aphthous stomatitis and thirtyhealthy controls from which saliva and blood samples were collected. Malondialdehyde as an oxidative stressbiomarker and total antioxidant status were measured in serum and saliva.Results: Malondialdehyde in serum and saliva was significantly higher in recurrent aphthous stomatitis patients incomparison to healthy controls (P<0.05). No significant differences were found in total antioxidant status betweenrecurrent aphthous stomatitis patients and control subjects (P>0.05).Conclusions: The changes in the oxidative stress in biological systems can be induced by the consumption ofantioxidants and/or by an overload of oxidant species, so the antioxidant defense system become deficient thatmay be important in the inflammatory reactions observed in recurrent aphthous stomatitis

المقدمة:یعتبر ألتھاب الفم القلاعي المتكررالمتكررة مدیات واسعة من الشدة تتراوح من الانزعاج البسیط الى الوھن الكامل بین المصابین.(Oxidative Stress) ھنالك العدید من العوامل التي یعتقد أنھا من مسببات ألتھاب الفم القلاعي المتكرر والتي یكون لھا في نفس الوقت تأثیر مباشر أو غیر مباشر على الشد التأكسديالضارة للخلایا الحیة. (Free Radicals) وبالتالي أنتاج الجذور الحرة (Antioxidants) و نظام مضادات العوامل المؤكسدة الدفاعیةمن جھة وأصابات ألتھاب الفم القلاعي (Antioxidants) ومضادات الأكسدة (Oxidative Stress) الھدف من الدراسة: الدراسة صممت لتحدید العلاقة الممكنة بین الشد التأكسديالمتكرر من جھة اخرى.الاشخاص والمواد وطریقة العمل: الدراسة شملت ثلاثون مریضا بألتھاب الفم القلاعي المتكرر وثلاثون شخصا طبیعیا للمقارنھ بینھما. وكانت المجموعتان متماثلتین بالجنس والعمر(Malondialdehyde ) MDA -20 ) وبعدھا تم حساب ºC) 55 ) سنة. اخذت العینات من مصل ولعاب المجموعتین وخضعت للطرد المركزي وخزنت عند - الذي یتراوح بین ( 14لكلا المجموعتین. (Total Antioxidant Status) TAS ولا توجد أختلافات ھامة في مؤشر .(P< كمؤشر للشد التأكسدي مقارنة بالأصحاء ( 0.05 (MDA) النتائج:أظھرت النتائج أن في الألتھابات الفمویة القلاعیة المتكررة أرتفاع ملحوظ في.(TAS)أو حمل زائد من العوامل (Antioxidants) في الأنظمة الحیویة ناجم عن أستھلاك مضادات الأكسدة الدفاعیة (Oxidative Stress) الأستنتاجات: أن التغیرات في الشد ألتأكسديالمؤكسدة وبالتالي عدم كفاءة النظام الدفاعي لمضادات العوامل المؤكسدة ومن ھذا نستنتج الدور الفاعل للشد التأكسدي كمسبب لمرض ألتھاب الفم القلاعي المتكرر.كذلك یمكن أستخدام اللعاب كسائل حیوي تشخیصي مؤثر وملائم لقیاس مؤشرات الشد التأكسدي ومضادات الأكسدة للمرضى المصابین بالألتھابات الفمویة القلاعیة المتكررة

Listing 1 - 3 of 3
Sort by
Narrow your search

Resource type

article (3)


Language

English (3)


Year
From To Submit

2013 (1)

2012 (2)