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Article
Evaluation of the efficacy of alum suspension in treatment of recurrent ulcerative ulceration

Authors: Tagreed S. ALtaei تغريد الطائي --- Raja H. AI-Jubouri رجاء الجبوري
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 2 Pages: 45-48
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Recurrent aphthous ulceration or recurrent aphthous stomatitis is the most common oral mucosal disease known to human beings. Despite much clinical and research attention, the causes remain poorly understood, the ulcers are not preventable, and treatment is symptomatic. The most common presentation is minor recurrent aphthous stomatitis: recurrent, round, clearly defined, small, painful ulcers that heal in 10 to 14 days without scarring. Major recurrent aphthous ulcerative lesions are larger (greater than 5 mm), can last for 6 weeks or longer, and frequently scar. The third variety of recurrent aphthous stomatitis is herpetiform ulcers, which present as multiple small clusters of pinpoint lesions that can coalesce to form large irregular ulcers and last 7 to 10 days. Diagnosis of all varieties is usually made after clinical examination. Alum Potassium aluminum sulfate, or ammonium aluminum sulfate, used especially as an emetic, an astringent, and a styptic.Patients and Method: A sample of fifty two patients were included in this study. 28 female, 24 male, ages range 20-40 years. They all participated in a randomized double-blind placebo controlled study. Patients with RAU were separated in to 5 groups, and these were treated with 1, 3, 5, 7 % of alum suspension, and placebo, applied topically four times daily, for five days treatment. Patients response to treatment was determined by; clinical evaluation of subjective treatment response, duration of lesion healing.Results: Statistical analysis of the effect on healing time of the three concentrations of the drug (3, 5, 7) had a significant reduction in the time required for complete healing of the ulcer compared with placebo group.Conclusions: Alum shortened the duration of healing on RAU with lack of any side effects

Keywords

Alum RAU


Article
The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers

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Abstract

Herpes labialis is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums, or the skin around the mouth. Although there is no successful treatment available, the local use of compounds with effective anti-inflammatory and cytoprotective effects may be of value in this respect. This project was designed to evaluate clinically the local use of silymarin, a group of flavonoids with powerful antioxidant, anti-inflammatory and cytoprotective activity, in the treatment of herpes simplex ulcer. Fifty three patients with herpes labialis ulcers (HLU) were enrolled in this randomized, single blinded, placebo controlled clinical study, and they were allocated into 4 groups, treated with 1%, 3% and 5% silymarin paste and placebo formula respectively. Patient's responses to treatment were followed by clinical evaluation of healing time, size of the ulcers and pain sensation, in addition to evaluating biochemical and immunological markers of the oxidative stress and inflammatory response. HLU patients showed dose dependent improvement in the healing time, pain score and size of ulcer as a result of treatment with various concentrations (1%, 3% and 5%) of silymarin paste, associated with improvement in the oxidative stress state and immunological parameters. In conclusion, silymarin can be used locally as paste formula for the treatment of HLU, an effect which may be attributed to its antioxidant, anti-inflammatory and cytoprotective properties.

Keywords

Herpes labialis --- ulcers --- silymarin

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