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Antioxidant Activity of 2-Amino-4-(3,4- Dichlorophenyl)-5-oxo-4, 5-Dihydropyrano (3, 2-c) Chromene-3-Carbonitrile Compounds

Authors: Yasameen K. Al-Majedy --- Hiba H. Ibraheem --- Talib K. Abed --- Khalid S. Reda --- et al.
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2018 Volume: 36 Issue: 2 Part (C) Pages: 179-183
Publisher: University of Technology الجامعة التكنولوجية

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Abstract

- Syntheses of coumarins, which are a structurally interestingantioxidant activity, was done in this article. The modification of 4-hydroxycoumarin by different reaction steps was done to yield targetcompounds. The structures of the synthesized compounds werecharacterized by spectroscopic methods, Infrared Spectra FT-IR and 1Hand 13C Nuclear Magnetic Resonance Spectra and elemental analysistechniques, melting point and thin layer chromatography. The antioxidantactivities of individual compounds were tested against hydrogen peroxide(H2O2) and ferric reducing antioxidant power (FRAP) and the results werecompared to the ascorbic acid and trolox as standards. The results showthat hydrogen peroxide scavenging activity of compounds 2and 3 are higherthan that of the standard, and the values are 81.1±1.0%, and 82.3±1.5%,respectively and the compounds 1 and 4show scavenging activity onhydrogen peroxide with lower value compared with ascorbic acid..

Keywords

antioxidant activity --- coumarin --- H2O2 --- FRAP.

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