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Oxidative Stress in Post-traumatic Stress Disorders for Terror Attack Victims in Iraq†

Authors: Abdulsamie H. Alta'ee --- Tarik Hufdy Al-Khayat --- Waleed Azeez Al-Ameedy --- Lamia Abdul Majeed
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2012 Volume: 22 Issue: 1 Pages: 408-416
Publisher: Babylon University جامعة بابل

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Abstract

Background: There is accumulating evidence for a link between posttraumatic stress disorder (PTSD) and reduced health status for terror attack victims.Objective: To assess the oxidants/ antioxidant status in patients with PTSD.Patients and Methods: 70 Iraqi subjects (59 males, 11 females) witnessed on Alnasej Factory explosion occurred at 10th June 2010 in Hilla city of Iraq, as well as 35 apparently healthy persons served as a controls group (21 males, 14 females) were subjected to present study. Participants were grouped to four groups according to PTSD Checklist (PCL) scores. Antioxidant enzymes superoxide dismutase (SOD) catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and lipid peroxidation were determined using spectrophotometric methods Results: The antioxidant enzymes activities, SOD, GPx, and peroxidation product MDA, found to be insignificantly increased in the present study, whereas, the antioxidant enzyme activity CAT and non-enzymatic antioxidant GSH showed an insignificant decreased in all groups of PTSD patients, when compared to control group. Also there are positive correlations between SOD, GPx and MDA, with severity of PTSD. Whereas; there is negative correlation between CAT and GSH with severity of PTSD.Conclusion: Results may indicate an involvement of mild oxidative stress in the pathogenesis of PTSD due to active hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-thyroid (HPT) axis.† This paper is a part of a doctoral thesis and the work is still underway to complete the study.

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Article
Serum Testosterone and Prolactin in Posttraumatic Stress Disorder for Iraqi Terror Attack Victims
تيستوستيرون وبرولاكتين المصل في مرضى اضطراب ما بعد الصدمة لضحايا العمليات الارهابية في العراق

Authors: Tarik Hufdy Al-Khayat --- Waleed Azeez Al-Ameedy --- Lamia Abdul Majeed --- Abdulsamie H. Alta'ee عبدالسميع حسن الطائي
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 2 Pages: 310-319
Publisher: Babylon University جامعة بابل

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Abstract

Background: Abnormal levels of testosterone and prolactin have been reported in various psychiatric disorders and the important roles of in the regulation of many processes in human metabolism have been described.Objective: Investigate the hormonal changes in posttraumatic stress disorder (PTSD) patients and control group.Patients and Methods: Eighty two males witnessed on explosion occurred at 10th June 2010 in Hilla city of Iraq, as well as thirty five males apparently healthy persons as a control groups. Participants were grouped to four groups according to PTSD Checklist (PCL) scores. Total testosterone, free testosterone, and prolactin (PRL) were determined using ELISA. Results: Total testosterone, free testosterone, and PRL showed an insignificant decreased in all groups of PTSD patients, when compared to control group. There is negative correlation between each of total testosterone, free testosterone, and PRL with severity of PTSD.Conclusion: Results of present study may indicate that there are inhibition of hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-prolactin (HPP) axes in PTSD patients.

الخلفية: لوحظ في العديد من الامراض النفسية مستويات غير سوية لكل من هرموني التيستوستيرون والبرولاكتين ولهما دورا مهما في تنظيم العديد من العمليات الايضية في جسم الانسان.الاهداف: التقصي عن التغيرات الهرمونية في مرضى اضطراب مابعد الصدمة.المرضى والطرق: شملت الدراسة اثنان وثمانون رجلا ممن شهدوا الانفجار الحاصل في العاشر من حزيران 2010 في مدينة الحلة- العراق وخمسة وثلاثون رجلا سليما ظاهريا كمجموعة سيطرة. قسم المشاركون الى اربعة مجموعات طبقا لدرجات لائحة اضطراب مابعد الصدمة . قدر التيستوستيرون الكلي والحر والبرولاكتين بتقنية الالايزا.النتائج: اظهرت النتائج انخفاضا غير معنويا في مستويات كل من التيستوستيرون الكلي والحر والبرولاكتين عند مقارنتها مع تلك النتائج المستحصلة لمجموعة السيطرة. ولوحظت علاقة سالبة بين كل من مستويات التيستوستيرون الكلي والحر والبرولاكتين شدة المرض.الاستنتاج: تدل نتائج الدراسة على تثبيط كل من المحورين الهرمونيين HPG و HPP عند المرضى باضطراب ما بعد الصدمة.

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