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Article
The Effect of Hyaluronic Acid and Platelet - Rich Plasma on Soft Tissue Wound Healing: An Experimental Studyon Rabbits

Author: Wafaa K Fathi
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2012 Volume: 12 Issue: 19 Pages: 115-125
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: This study aimed to evaluate the benefits of using platelet– rich plasma and hyaluronic acid when used alone or in combination with each other on wound healing. Materials and methods: The study performed on 15 adult male rabbits divided into three group according to healing periods (3,7,14 days), each group containing 5 animals. Four longitudinal incisions were made on the back of each rabbit, 2 in the right and 2 in the left. A distance of about 1.5 cm was left between one incision and another. The defects were filled with platelet–rich plasma, hyaluronic acid, or mixture of both, and the last incision served as control. Animals were sacrificed at 3rd, 7th, and 14th day after intervention, and biopsy were taken. Histopathological analyses were performed to evaluate the effect of these materials on acceleration of wound healing of skin. Statistical analyses was performed with Analysis of Variance and Duncan's Multiple Range Analysis Test, using a significant level of p ≤ 0.01. Results: Histopatho-logical analysis revealed significant improvement of wound healing when treated with PRP, and with mixed application of PRP and HA compared with control and HA groups in 3rd and 7th day postope-ratively, while there was no significant differences in wound healing between all groups at the end of the second week. Conclusions: The use of PRP alone or in combination with HA will accelerate wound healing , while the use of low concentration of HA alone presents no improvement of wound healing in comparison with normal one.


Article
A clinical comparative evaluation between upper and lower first molar apicectomy procedures (A retrospective trial).

Authors: Wafaa K Fathi --- Wael T Al Wattar
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 18 Pages: 381-389
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: The aim of this retrospective clinical trial was to evaluate and compare the upper and lower first molar apicectomy procedures in terms based on certain clinical criteria selected. Materials and Meth-ods: This clinical trial was conducted at the Department of Oral and Maxillofacial Surgery / College of Dentistry / University of Mosul. The sample recruited was composed of forty healthy subjects who required apicectomy procedures on either an upper or lower fist molar. The sample was subdivided into two groups of twenty subjects each. The first group comprised those patients where root end resection ( apicectomy ) on an upper first molar tooth was required. The second group included those patients who required an apicectomy procedure on one of their lower first molar tooth . Criteria that were eval-uated and compared included pain, swelling and trismus which were evaluated on the first operative day, second, third and seventh postoperative day. Results: A significant difference was observed be-tween recall visits in regard to the pain level of mandibular procedures and was also observed in maxil-lary procedures. In regard to pain level assessment between mandibular and maxillary procedures, a significant difference was observed with pain levels higher in mandibular procedures for the second and third day when compared to maxillary procedures. A significant difference was observed between recall visits in regard to swelling of soft tissue of mandibular and maxillary procedures. Concerning grade of swelling assessment between mandibular and maxillary procedures, a significant difference was observed with swelling of soft tissue higher in mandibular procedures on the second and third day when compared to maxillary procedures. A significant difference was observed for limitation of mouth opening in mandibular procedures between recall visits specifically on the first and second day but was not observed in maxillary procedures. When comparing between upper and lower surgical procedures, a significant difference was observed in trismus specially on the second and third post-operative day and which was more pronounced in mandibular procedures. Conclusions: It seems that complications following root end resection on lower first molar teeth are more evident when compared to the upper first molar region, but only in the first few days following surgery. However, such complications were tolerable to the patient and can be overcome by medications and exercise. Such complications should not hinder the oral surgeon from performing endodontic surgery on posterior teeth when indicated


Article
Single Buccal Injection for Anesthesia of Upper First Molar

Authors: Mohamed S. Suleiman --- Wafaa K. Fathi --- Rayan S. Hamid
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2008 Volume: 8 Issue: 11 Pages: 56-60
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: A clinical trial was carried out to assess the efficiency of a single buccal injection to achieve
anesthesia of the buccal aspect of the upper first molar instead of the traditional two injections. Materials
and Methods: The subjects included in the clinical assessment were those needing extraction of
an upper first molar of either side. For the purpose of comparison, the sample was randomly divided
into two main groups: Group I (control group) which included 100 subjects who were to receive two
buccal injections and a single palatal injection before extraction. While Group II (trial group) included
100 subjects who were to receive a single buccal injection and a single palatal injection before extraction.
The following data were recorded: Pain on needle insertion, pain on deposition of solution, onset
of surgical anesthesia and adequate surgical anesthesia. Results: The first criterion recorded was pain
on needle insertion where the results showed no significant difference between both groups. The
second criterion was pain on deposition of solution. Here the results also showed no significant difference
between both groups in this aspect. For onset of surgical anesthesia, no significant difference was
shown between both groups. In regard to pain grade experienced during surgery for both groups, the
results showed that grade A anesthesia was recorded in 95% of patients in group I , whereas in 93% of
patients in group II. Grade B anesthesia was recorded in 5% of patients in group I and in 7% of patients
in group II. Statistically speaking, no significant difference was disclosed in regard to pain assessed
during the extraction of the tooth between both groups. Conclusions: The achievement of successful
local anesthesia is a continual challenge in dentistry. Any suggested new approach for achieving adequate
anesthesia for either the maxilla or mandible as long as it is safe and effective can be recommended
for routine dental care.


Article
The Effect of Tranexamic Acid (Cyclokapron) on Post–Surgical Bleeding Following the Removal of Impacted Lower Wisdom Teeth in Healthy Individuals

Authors: Wael T. Al Wattar --- Wafaa K. Fathi --- Rayan S. Hamid
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2008 Volume: 8 Issue: 12 Pages: 225-230
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To evaluate the effect of local irrigation with tranexamic acid in minimizing post–operativebleeding following the removal of impacted lower wisdom teeth. Materials and Methods: This clinicaltrial was conducted at the Department of Oral and Maxillofacial Surgery / College of Dentistry / Universityof Mosul. The sample recruited comprised twenty healthy subjects who required surgical removalof clinically as well as radiographically evident impacted lower wisdom teeth. The sample wassubdivided into two groups of ten subjects each. The first group which is the control group included tensubjects where after removal of the tooth, local irrigation of socket was carried out with normal saline.The second group which is the trial group comprised ten subjects also, but in which tranexamic acid(injectable solution) in diluted form was used for local irrigation of socket. Both solutions were of equalamount. Estimation of amount of blood loss immediately following surgery was the criterion for comparisonand was based on weight of gauze used before and after application over extraction socket. Results:The results showed a statistically significant decrease in the amount of blood loss in the trialgroup when compared with the control group. Conclusions: Tranexamic acid as commercially availableor freshly prepared oral rinse may be used as an aid for the reduction or prevention of postoperativebleeding following the removal of third molars in healthy subjects as well as in patients with bleedingproblems.

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