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Ki-67(MIB-1) and Progesterone Receptor in Meningioma An Immunohistochemical Study

Author: Wahda Mohammed Taib Al- Nuaimy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 2 Pages: 157-167
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: In meningioma the tumor grade, subtype, and extent of surgical resection are strong prognostic factors, the growth of this tumor is still unpredictable, and additional prognostic markers are needed. Many studies have shown that the detection of the proliferative potential of meningioma by Ki-67 (MIB-1) and the detection of the progesterone receptor might predict the natural history of tumor and patient survival. OBJECTIVE: To evaluate the proliferative fraction Ki-67 (MIB-1) and progesterone receptor in meningioma, To correlate the expression of these two markers with various clinico- pathological parameters, To compare these results with other studies . PATIENTS AND METHODS: This is a prospective study, in which 50 cases of meningioma were collected in Nineveh province. These cases were examined immunohistochemically. The results of these two markers were correlated with various clinico- pathological parameters. RESULTS: The mean age of all cases was 46 years. There were 16 male and 34 female patients. According to the W.H.O 2000 classification, there were 84% grade I, 10% were grade II and 6 %were grade III. Only 14% of the patients had a history of recurrence. Progesterone receptor was positive in 72% of all cases. Significant relation was observed between the progesterone receptor and the patients age .It was significantly higher in female than male. A significant relationship was found between progesterone receptor with grade and histological types. Thirty three out of 43 cases without recurrence had positive progesterone receptor. The mean±Standard deviation (SD) of Ki-67 Labeling Index (Ki-67 LI) was 2.7±4.2%. No significant relation was found between the Ki-67 LI and patients age. The male patients had a higher Ki-67 LI than that of the female. Significant relation was found between Ki-67 LI and the grade of meningioma . The mean of Ki-67 LI in the recurrent cases was higher than in non recurrent cases. An inverse relationship was found between Ki-67 LI and progesterone receptor . CONCLUSION: Progesterone receptor showed a significant relation with the age and histological types. Ki-67 LI had a direct significant association with the grade and the recurrent cases., while inverse relation was observed between the progesterone receptor with the grade and the recurrent cases. An inverse relationship was observed between the progesterone receptor and Ki-67 LI.


Article
Detection of vascular invasion in colorectal cancer by using Weigert's stain for elastic fibers

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Abstract

Objective: Venous invasion is stage independent prognostic risk factor for distant metastasis in colorectal cancer. Elastic stain is among the various ancillary techniques that were described to increase the sensitivity of detection of vascular invasion. This combined prospective and retrospective study is aimed to assess the sensitivity of elastic tissue stain to detect venous invasion in comparison to the routine H & E stained sections, and to correlate intramural and extramural venous invasion with the Dukes staging system. Method: Serial sections from 42 cases of colorectal cancer diagnosed between the years 2007 and 2009 were examined by using H & E and Weigert's stain. A comparison was drawn between the two stains in regard to venous invasion; the results were correlated with Dukes stage for colorectal cancer.Results: The mean age of sampled patients was 50 years. Venous invasion was detected in 16 (38%) cases by the use of H & E stain, which was increased to 35 (83%) cases by the use of Weigert's stain for elastic tissue with a clear statistical significance (P<0.001). Venous invasion was correlated with Dukes B & C cases with a P value of more than 0.05 & less than 0.01 respectively. Conclusion: The use of elastic tissue stain on one tissue block increases significantly the frequency of detection of vascular invasion of colorectal cancer.Keywords: Venous invasion, colorectal cancer, Weigert's stain, elastic fibers

الأهداف: تعد اختراقات الأوعية الدموية لسرطان القولون والمستقيم من عوامل الخطورة الانذارية لانتشار السرطان عن طريق الدم والذي لا يعتمد على مرحلة المرض. تعتبر صبغة الألياف المطاطية واحدة من التقنيات المساعدة المتعددة لزيادة حساسية الكشف عن اختراقات الأوعية الدموية. تهدف الدراسة الاستقبالية والتراجعية الى تقييم حساسية صبغة الألياف المطاطية في الكشف عن اختراقات الأوعية الدموية ومقارنتها مع مقاطع الأنسجة المصبوغة بصبغة هيماتوكزيلين-أيوسين الروتينية مع ربط اختراقات الاوردة ضمن الجدارية وخارج الجدارية مع مرحلة نظام ديوك.طريقة العمل: تم أخذ مقاطع متسلسلة لـ (42) حالة لسرطان القولون والمستقيم المشخصة بين 2007-2009 وتم فحصها بعد صبغ المقاطع النسيجية بصبغتي هيماتوكزيلين-أيوسين وفيكرت للألياف المطاطية وتمت مقارنة نسبة وجود اختراقات الأوعية الوريدية باستخدام الصبغتين وتم ربط النتائج بمرحلة ديوك لسرطان القولون والمستقيم.النتائج: كان معدل أعمار المرضى 50 سنة. وجدت اختراقات الأوعية الوريدية في 16 حالة ( بنسبة 38 %) باستخدام هيماتوكزيلين-ايوسين بينما ارتفعت القيمة الى 35 حالة (بنسبة 83%) بعد استخدام صبغة الألياف المطاطية لنفس المقاطع النسيجية مع قيمة احصائية واضحة (قيمة P اقل من 0,001) كما ربطت الاختراقات الوريدية بمرحلتي ديوكB وC مع قيمة P أكثر من 0,05 واقل من 0,01 بالتتابع.الاستنتاج: استخدام صبغة الألياف المطاطية لمقطع نسيجي واحد يزيد من أهمية تكرار الكشف عن الاختراقات الوريدية لسرطان القولون والمستقيم.

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