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CELLULAR CYTOGENETIC STUDY FOR TREATED ROLE OF SELENIUM AND OLIVE OIL AS AN-ANTIOXIDANTS AGAINST LEAD POISONING IN FEMALES MICE BONE MARROW CELLS
دراسة وراثية خلوية للدور العلاجي للسلينيوم وزيت الزيتون كمضادات للاكسدة ضد التسمم المستحدث بالرصاص في نخاع العظم للفئران المختبرية

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Abstract

The present study was designed to investigate the cellular cytogenetic effect of lead poisoning and the therapeutic role of selenium and olive oil as an antioxidant in mouse bone marrow cells.Twenty one female mice, 12 weeks old, and of 20–25 gram weight were used. The female mice which divided into seven groups each group consist of 3 female mice ,the control group: oral giving by 0.9 % normal saline (N.S) daily for 28 days. The treated groups A,B,C,D,E,F: received orally with 50 mg/kg BW lead acetate, 50 mg/kg of lead acetates + o.5 mg/kg of selenium, 50 mg/kg of lead acetates +0.2 CC of olive oil, 100 mg/kg of lead acetates, 100 mg/kg of lead acetates+ o.5 mg/kg of selenium, 100 mg/kg of lead acetates+0.2 CC of olive oil daily for28 days respectively,The administration of different doses of lead acetate caused a significant increase (P <0.05) in number of chromosomal aberration in mouse bone marrow (ring chromosome, fragment, centric fusions and centromeric attenuation )the high dose caused more increase in number of chromosomal aberration in at 28 days especially ring form.The treatment with antioxidants selenium (0.5mg/kg.B.W) and olive oil (0.2cc) caused decreased chromosomal aberration number.Also, the results showed that lead acetate caused a significant decrease (P <0.05) in the mitotic index parameter whereas the treatment with antioxidant caused an increase number of mitotic index in mouse bone marrow cells during 28 days.

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