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The Effect of the Aqueous Extract of Peganum harmala Seeds on the Mammary Glands of Virgin, Pregnant, and Lactating Rats

Author: Wasan Al- Saidi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 2 Pages: 191-198
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Penganum harmala is a well known herb that is used by different societies. It is used as a medicalherb in treating various diseases and disorders .There was no earlier published work on the effects ofthe aqueous extract of Peganum harmala . Therefore, we designed this study to investigate the effectof the aqueous extract of Peganum harmala seeds on the mammary gland at the various physiologicalstates (virgin, pregnancy and lactation) making use of the available histological, histochemical, andimmunohistochemical means.METHODS:Aqueous extract of Peganum harmala was given for two weeks by an orogastric tube on single regulardaily dosage to Norway albino female rats. Animals were subdivided into subgroups according totheir physiological states. Mammary glands of these animals were routinely processed for histological,immunohistochemical and histochemical studies using formalin fixative ,paraffin embedded sectionsin the first two studies and formal calcium, frozen sections in the third study. Experimental specimenswere compared with that of control subgroups.RESULTS :Harmal induced mammogenesis in the mammary glands of virgin rats. It's aqueous extract was able toinitiate lactogenesis in a well-prepared mammary gland (i. e. during pregnancy) and finally thisaqueous extract promotes lactogenesis when administrated during lactation.CONCLUSION :Peganum harmala is a mmammogenic herb .KEYWORDS: Peganum harmala, mammary


Article
Observations on the ultrastructure of a rat mammary gland treated with harmal and borage

Authors: Salim R. Hamoudi ** --- Shatha M. Al-Faisaly*** --- Wasan Al- Saidi * --- Malak A. Al- Yawer **Ph.D
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 151-156
Publisher: Baghdad University جامعة بغداد

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Abstract

Background : It had been indentified by histological, histochemical and morphometrical studies that peganum harmala is a mammogenic herb and borage officinalis is a lactogenic one . To complete our investigation about these two herbs , we performed electron microscopical study . Materials and methods : Rats were grouped according to their physiological status into three groups . Each group was subdivided in to three subgroups : one control and two experimental . The two experimental group were treated daily; the 1st one with an aqueous extract of peganum harmala seeds and the 2nd with an aqueous extract of borage officinalis flowers . After two weeks of treatment , mammary glands were employed for electron microscopical study . Results : In virgin rats , the epithelial and myoepithelial cells were partially differentiated when harmal was given and completely differentiated when borage was given . In pregnant rats , harmal and borage optimize mammary parenchymal growth and induce lactation when these herbs were given. In lactating rats ,these herbs exhibited a picture similar to control lactating group but the budding of lipid droplets and the swelling of secretary vesicles were markedly increased . Conclusion: Both harmal and borage stimulate the release of prolactin and induce galactogenesis during pregnancy and promote it during lactation . Key Words : Mammary gland , Electron microscope , Harmal , Borage


Article
Elucidation of a Role for the Aqueous Extract of Borage in Mammary Gland Growth and Development

Authors: Wasan Al- Saidi --- Malak Al- Yawer --- Hana Mangalo --- Salim R. Hammoudi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 54-61
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACK GROUND : Herbal remedies are used in induction of lactation . In view of that ,Borage Officinalis was employed to ensure an abundant milk supply or rectify milk insufficiency .However ,this remedy has not been scientifically tested . METHODS: The animals were treated with the aqueous extract of Borage Officinalis flowers at a daily concentration of 100 mg / kg body weight /ml for each rat through Oro-gastric tube for 14 days . Animals were subdivided into subgroups according to their physiological status . Mammary glands of these animals were processed for histological , histochemical and immunohistochemical studies . RESULTS: The results of all parameters indicated that the aqueous extract of Borage Officinalis flowers induced lactogenesis in the mammmary glands of virgin and pregnant rats and promoted lactation when had given to lactating rats . CONCLUSION : Borage Officinalis is a lactogenic herb

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