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treatment of pityiasis versicolor with two weekly dose of systemic fluconazole

Author: wifaq M. Al-Wattar وفاق محمود الوتار
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 3 Pages: 253-255
Publisher: Baghdad University جامعة بغداد

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Article
The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients

Authors: Khalida M .Al-Moussawy --- Nahla Ghanim --- Wifaq M. AL-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 111-115
Publisher: Baghdad University جامعة بغداد

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Background: Tinea versicolor is a common dermatological problem ,world wide distribution ,caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal .Many factors play a role in the etiology of TV among these could be the disturbed immune systemwhich may be related to the ability of TV alter the immune system by a process calledImmunomodulation leading to subsequent infection.Immuno-inflammatory activity mediated by different cytokines could have a role in the etiologyof TV.Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients withTV as compared to immunocompramized patients and healthy groups.Patients and methods: This study enrolled 50 total patients, 15 of them were as patients controlgroup who were immunocompramized with evident skin lesion ,to be compared serologically with 15patients who had TV and normal immunity, the control group composed of20 healthy volunteers.Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera ofall groups.Results and discussion: The statistical differences in the rate of detectable IL-4 level between TVand healthy control p< 0.001,while the difference was a highly significant between the healthycontrol and immunocompramized patients with TV,P<0.00338.The difference between twodiseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant.IL-8 the results of our study showed a significant difference between the healthy control and thepatients with tinea versicolor, p-value was( 0.05).In this study there was a nice findings by which the difference between the healthy control and theimmunocompramized patients was highly significant as ,p<0.005.Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it actsas an adjuvant, activates the complement cascade, and elicits both cellular and humoral immuneresponses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast,it also seems to have the ability not only to evade the immune system but actually to suppress theresponse directed against


Article
Bacteriology of the Core of Adenoids inA group of Iraqi Patients Undergoing Adenoidectomy.

Authors: Eman F. Abdullah --- HusseinM.Hassan, --- Wifaq M.Al-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 4 Pages: 391-393
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Upper air way obstruction secondary to chronically inflamed adenoid and / or tonsil is a common problem, in the presence of recurrent infection; tonsillectomy and or adenoidectomy are the most common surgery applied among pediatric population.
Objective: The aim of this study was to assess the type of bacteria encountered with- in the core of the adenoid tissue at time of operation.
Subject and Methods: During a period from Feb.2005 to May 2005, twenty two adenoid samples were removed by surgery ,and cross sectioned and sent for culture and sensitivity, at the department of ENT in Al-jerahat hospital for surgical specialties , most of the patients were under 10 year’s old.
Results: This study showed that the bacteria isolated from the core of adenoid tissue were mostly part of bacterial flora of the upper respiratory tract, only 7 patients showed a growth of pathogenic bacteria; to which special sensitivity tests were performed to detect antibiotic sensitivity.
Conclusion: The bacteria of the core of the adenoid were mostly composed of normal flora, and few of them were pathogenic and resistant to most ordinary antibiotics


Article
The role of IL-6 in the etology of tinea versicolor in group of Iraqi patients.

Authors: Mukarum AL-Waiz --- Khalida M. AL-Mussawy --- Wifaq M. AL-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 2 Pages: 192-194
Publisher: Baghdad University جامعة بغداد

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Background Tinea versicolor is a common dermatological problem worldwide in distribution, caused by dimorphic fungus called Malassezia furfur, they exist at the very interface between commensal and pathogen and, as such, their interaction with the human immune system is of great interest. Immuno-inflamatory activity mediated by different cytokines could have a role in the etiology of tinea versicolor.
Patients and Method: The study covered 46 subjects .It comprised 26 patients with TV compared with 20 healthy normal controls. Serum IL-6 analysis was done by ELISA.
Results: The level of IL-6 was elevated in patients with tinea versicolor, when compared with healthy control. Conclusion: IL-6 increases during the infection and could be part of a complex immune response leading to fungal elimination from human body.

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