research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Gynecomastia Treatment Should it be Individualized? A Prospective Study

Authors: Riyadh M Hassan --- ,Zuhair B Kama --- Wisam Abdul lateef Hussein*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 394-402
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND :Gynecomastia is a benign enlargement of the male breast.OBJECTIVE:Was to analyze a 3 year period of gynecomastia patients in Al-Kindy Teaching Hospital and the surgical approach used and its outcome.PATIENTS AND METHODS:A prospective study of patients consulting Al-Kindy Teaching Hospital because of gynecomastia between October 2007and August 2010 was done. Data were analyzed for etiology, grade of gynecomastia, surgical technique, complications, and histological results.RESULTS:A total of 64 patients with 86 operations were included. Techniques included subcutaneous mastectomy alone, or subcutaneous mastectomy with wise pattern "inverted T incision". Atypical histological findings were found in 3.12% of the patients (papilloma, fibrolipoma). Surgical revision among all patients was 7%. Body mass index higher than 25kg/m2 was found as significant risk factors for complications (p.043), and that higher grades of gynecomastia (grade IIb and III )had higher statistical incidence of complications p= 0.01CONCLUSION:The treatment of gynecomastia requires an individualized approach. Caution must be taken in high BMI and higher grades, which are associated with increased complication rates. Histological tissue diagnosis should be routinely performed in all true gynecomastia corrections, because histological results may reveal atypical cellular pathology.


Article
Immunohistochemical expression of Cyclin D1 in mucoepidermoid and adenoid cystic carcinoma of the salivary glands

Loading...
Loading...
Abstract

Background: Cyclin D1 proto-oncogene is an important regulator of (G1 to S) phase progression in many differentcell types. The Aims of this study were to evaluate the immunohistochemical expression of Cyclin D1 inmucoepidermoid and adenoid cystic carcinoma of the salivary glands and to correlate the immunoexpression ofthis protein with the clinicopathological findings.Materials and methodsRetrospectively, twelve of archival formalin fixed paraffin embedded tissue samples of salivary Mucoepidermoid andfourteen blocks of adenoid cystic carcinomas obtained from the archives of the department of oral pathology /college of dentistry / Baghdad university, Al-Shaheed Ghazi hospital, were included in this study. Five micrometersections obtained and immunostained using monoclonal antibody against Cyclin D1. The immunoexpression wasdetected by the presence of brown stain in the nucleus of tumor cell. The proportion of cells that expressed the stainwas correlated with the clinicopathological data of the patients.Results: Cyclin D1 expression was found positive in all cases of MEC and AdCC localized in tumor cells. Nonsignificantstatistical relation (p=0.588) was detected regarding Cyclin D1 expression in both types of tumor.Significant relation was found with stage of AdCC (p=0.04) and non-significant concerning other clinicopathologicalparameters in both tumor types.Conclusion: Weak expression of Cyclin D1 in MEC and AdCC might be explained by Cyclin D1 does not represent anexclusive factor consequently; other factors might be involved in the proliferation, progression and metastasis of bothtumor types.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2015 (1)

2011 (1)