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AMELIORATING AND PROTECTIVE ROLE OF QUERCETIN AGAINST O-ANISIDINE TOXICITY ON SOME REPRODUCTIVE ASPECTS OF LABORATORY MALE RATS (Rattus norvegicus).

Author: Wissam Sajid Al-Uboody , Muhammed Ali Al-Diwan
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2015 Volume: 14 Issue: 1 Pages: 250-261
Publisher: Basrah University جامعة البصرة

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Abstract

The present study assessed the effects of O-anisidine hydrochloride and theameliorating effect of Quercetin dihydrate in laboratory rats. Sixteen male and thirtytwo female rats (Rattus norvegicus) were used and divided into eight equal groups oftwo male and four female rats each. The results revealed that the treatment with Oanisidinehydrochloride for 30 days (T1, T2 and T3 groups) caused significantdecrease in the males body weights, sperm count, individual and massive spermmotility, testes weights, and epididymis weights as compared with control and (T4,T5, T6 and T7) groups at (P≤0.05).When Quercetin dihydrate was offered as anameliorating agent, it showed a significant ameliorating effect by increasing the bodyweights, sperm count, individual and massive sperm motility, testes weights, andepididymis weights . When Quercetin dihydrate was offered alone in the ration of thesixth treated group (T6), it caused clear significant ameliorating effect on all spermparameters comparing with all treated groups and the sperm count was evensignificantly higher than that of control group while the other aspects were similar tothose of control group at (P≤0.05). Beside, O-anisidine caused significant decrease inthe number of pregnant females, number of delivered litters, weight of litters and sexratio, and it prevented the pregnancy from being occurred in the group where bothmale and females are treated with it (T1). When Quercetin was mixed with Oanisidinein the ration of (T7), it significantly ameliorated the pregnancy chances,number of litters and the sex ratio as compared with the other groups but it didn’treach to significant level with control group at (P≤0.05).

Keywords

O-anisidine --- pregnancy --- Rats.


Article
STUDY THE PROTECTIVE ROLE OF QUERCETIN AGAINST O-ANISIDINE TOXICITY ON SOME HEMATOLOGICAL PARAMETERS OF LABORATORY MALE RATS (RATTUS NORVEGICUS).

Author: Wissam Sajid Al-Uboody,Muhammed Ali Al-Diwan
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2015 Volume: 14 Issue: 1 Pages: 263-273
Publisher: Basrah University جامعة البصرة

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Abstract

The study was designed to assess the protective role of Quercetin against Oanisidinetoxicity. 24 male rats (Rattus norvegicus) were used and divided into 3 equalgroups of 8 male rats each. The first group was the control group in which the animalswere fed on a standard ration for 15 days, then they were terminated. The secondgroup was fed on a ration contains 1000mg/kg O-anisidine hydrochloride for 15.Thethird group was fed on a ration contains 1000mg/kg O-anisidine hydrochloride +80mg/kg Quercetin dihydrate for 15. The results revealed that the treatment with Oanisidinehydrochloride for 15 days (1rst treated group) caused significant decrease inthe R.B.C. count, Hb concentration, P.C.V. percentage, neutrophil and lymphocytecounts and it caused significant increase in platelets count, total leukocytes,monocytes, eosinophil and basophil counts, as compared with control group. WhenQuercetin dihydrate was offered as a protective agent in the ration of the 2nd treatedgroup, it showed a significant ameliorating effect by increasing the R.B.C. count, Hbconcentration, P.C.V. percentage, neutrophil and lymphocyte counts and it causedsignificant decrease in platelets count, total leukocytes, monocytes, eosinophil andbasophil counts, as compared with the 1rst treated group. For the blood indices(RDW, MCH, MCHC, MCV, and MPV) there were no significant differences amongall the experiment groups except for the mean platelet volume (MPV), where Oanisidinehydrochloride caused significant decrease in the MPV of the 1rst treatedgroup as compared with control and 2nd treated group at (P≤0.05).

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