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Article
C-reactive protein and plasma fibrinogen in patients with stable angina pectoris

Author: Yasin A. Baqir
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 193-196
Publisher: Babylon University جامعة بابل

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Abstract

The study included 48 patients with stable angina pectoris and 41 control subiects to evaluatelhe association between inflammatory markers (C-reactive protein and plasma fibrinogen) and anginaPectoris.The study revealed that plasma fibrinogen (P<0.001), C-reactive protein (P<0.01), as welt aslipid profile (total cholesterol (P<0.001), low-density lipoprotein chotesrerol (p<0.01), triglycerides(P<0.01) and low-densib, lipoprotein cholestercl,&igh-densiq, iipoFotein cholestercl rario (p<0.01)were significantly higher anong patients with stable angim pectoris compared to controls. Wlile, rherewas ro significant diferences in high-density, lipoprotein chotesterol level between patienB anoonnols ( P 0.05).The present study clearly demonstmted a strong association berween inflanmatory markersand angina pectotis, suggesting a role for these rnarken in the pathogenesis and the progression ofcoronary heal.t disease

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Article
SERUM CREATINE KINASE ACTIVITY IN THYROID DYSFUNCTION

Author: Yasin A. Baqir
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2003 Volume: 9 Issue: 2 Pages: 167-170
Publisher: Basrah University جامعة البصرة

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Abstract

The serum activity of creatine kinase was determined in 52 patients with hypothyroidism (19 males and 33 females), 110 patients with hyperthyroidism (27 males and 83 females) and 187 control subjects (47 males and 140 females). The creatine kinase activity in patients with hypothyroidism was on the average significantly higher than controls (p<0.005). In hyperthyroid patients, although the serum activity of creatine kinase was significantly lower as compared with controls, however, it is within the normal range. Hypothyroidism should be put into consideration in patients presented with symptoms suggestive of cardiovascular abnormality without other evidence of myocardial damage and have raised creatine kinase activity.

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Article
Evaluation of Tfyroid Hormone Profile in Patients with Suspected Thyroid Dysfunction in Basrah

Authors: Salman K. Ajlaan --- Yasin A. Baqir
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 2 Pages: 197-203
Publisher: Babylon University جامعة بابل

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Abstract

One thousand and seven patients (277 males and 730 fenales ) with suspected thfoiddystunction werc studied for changes in serum levels of thlroxine (Ta), ri-iodoth).ronire (Tt andtb,roid-stimulating homone (TSH). Among males, Thyroid homone tests rcvoaled that 89 (32.1%)patients were hyperthyroid, 42 (15.2yo, 1erc hr?othyroid and 146 (52J%) w€re eulhyroid. Thecompamtivc figures for females were 197 (27.0%),108 (14.870) and 425 (58.270) respectively. Thyroidhormone tests confirmed ihe initial clinical diagnosis in 436 (43.370) patients, wherc m only 4'l.3vo ofmale and 41.8% of female patients, the initial diagnosjs was confimred by hormonal tests. AmonghypethFoid male patients, 58 (62.5010) showed conventioml thyrotoxicosis (increased both serxm Taand T3 levels), 17 (19.1%) Fesented with Ta toxicosis, and. 14 (15.'7o/o) wilh T3 toxicosis.Comparatively, the figures in f€males were 144 (73 .l%),41 Q0.8%) and, 12 (6.1%) respectively.The study focused a light on rhe importance ofthe correjarion of tbToid hormone changeswith the clinical picture, and also, on the essential role of TSH assay in the diagnosis of thyroid disease

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Article
Changes of Liver Enzymes in Coronary Heart Disease

Authors: Salman K. Ajlan --- Yasin A. Baqir
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 1 Issue: 9 Pages: 994-1001
Publisher: Kerbala University جامعة كربلاء

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Abstract

background : Coronary heart disease is one of the leading causes of morbidity and mortality elsewhere in the world . An association between liver enzymes and coronary heart disease is suggested.Objective: To evaluate the changes in liver enzymes, Alanine aminotransferases andaspartate aminotransferases in patients with coronary heart disease.Methods: The study included 60 patients with coronary heart disease (41 males and 19 females), and 40 control subjects (25 males and 15 females) from Basrah, Iraq. Alanine aminotransferase, aspartate aminotransferase, lipid profile and fasting blood glucose levels were determined.Results: alanine aminotransferase , aspartate aminotransferase, fasting blood glucose, totalcholesterol, triglycerides, and low density lipoprotein- cholesterol levels were significantlyhigher among coronary heart disease patients compared to controls (P<0.001), while highdensity lipoprotein- cholesterol level was significantly lower among patients with coronaryheart disease in comparison to controls (P<0.001). Alanine aminotransferases revealed asignificant positive correlation with triglycerides (P=0.006), and significant negativecorrelation with high density lipoprotein- cholesterol (P= 0.031) and no significantcorrelations with body mass index, blood pressure, and other biochemical parameters(P>0.05). On the other hand, aspartate aminotransferases showed significant positivecorrelations with total cholesterol (P=0.009), triglycerides (P=0.025) and low densitylipoprotein- cholesterol (P=0.042), and no significant correlations with other physiologicaland biochemical parameters (P>0.05).Conclusions: A strong association exists between changes in liver enzymes, alanine aminotransferase and aspartate aminotransferase and coronary heart disease. These enzymes could be included within the increasing list of coronary heart disease risk factors. Also, they might have prognostic significance and a predictive value in coronary heart disease complications.Key words: Coronary heart disease, liver enzymes, lipid profile.


Article
CHANGES OF SERUM BILE ACIDS IN LIVER DISEASES
التغير في مستويات أحماض الصفراء لدى مرضى الكبد

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Abstract

ABSTRACTThe present study was carried out to evaluate the clinical usefulness of measuring total serum bile acids concentrations as a diagnostic test for hepatobiliary diseases. It is measured by an enzymatic method under fasting conditions in 120 apparently healthy control subjects and 140(79 (56.43%) males and 61(43.57%) females) patients with various forms of hepatobiliary diseases. The patient's diagnoses were based on clinical, biochemical, radiological, serological and histological grounds. The study showed a highly significant increase in total serum bile acids levels in all types of liver disease patients groups (icteric and anicteric) (P<0.001), even when other liver tests are normal. There were no significant differences (P> 0.05) in the serum levels of total bile acids in patients groups according to their gender and residence. The highest incidences of hepatobiliary diseases were in males and urban patients groups as compared with females and rural patients groups respectively. The study has illustrated moderate correlations between the concentrations of total bile acids with those for any the other liver function tests. Highly significant, positive and moderate correlations were observed with total bilirubin concentration (r = 0.659, P < 0.01). On the other hand serum total bile acids were negatively correlated with serum albumin (r = - 0.104).

1 فرع الكيمياء الحياتية / كلية الطب / جامعة البصرة، 2 فرع الطب الباطني / كلية الطب / جامعة البصرة و 3فرع الأحياء المجهرية / كلية الطب / جامعة البصرةأجريت الدراسة لتقيم الفائدة السريرية من قياس التركيز الكلي لأحماض الصفراء في مصل الدم كاختبار تشخيصي لدى مرضى الكبد و المرارة. قياس التركيز الكلي لأحماض الصفراء في مصل الدم بواسطة طريقة إنزيمية قياسية في حالة الصيام. تم شمول 120 شخصا من الأصحاء و 140 مريضا من المرضى المصابين بمختلف أمراض الكبد و المرارة 79 (56.43 %) من الذكور و61 (43.57%) من الإناث. اعتمد تشخيص المرضى على الفحص السريري والشعاعي والنسيجي والسير ولوجي ونتائج فحوصات الكيمياء الحياتية السريرية. أظهرت النتائج إن هناك زيادة معنوية كبيرة في التراكيز الكلية للأحماض الصفراء في مصل الدم في حالة الصيام في كل مجاميع مرضى الكبد (P<0.001) حتى عندما تكون فحوصات الكبد الأخرى طبيعية. لايوجد اختلاف معنوي (P>0.05) بين مستويات أحماض الصفراء في مرضى الكبد بالنسبة لجنسهم ومحل سكناهم. إن نسبة الإصابة بإمراض الكبد لدى الذكور والساكنين بالمدينة هي الأعلى بالمقارنة مع الإناث والساكنين بالأرياف, بالترتيب. وكذلك أظهرت الدراسة أيضا وجود ترابط نوعي طردي غير عالي بين التركيز الكلي للأحماض الصفراء في مصل الدم لمجاميع من مرضى الكبد مع فحوصات الكبد الأخرى المشمولة في الدراسة، فقد أظهرت ترابط معتدل موجب ونوعي مع تركيز البليروبين الكلي (r = 0.659, P < 0.01). بينما وجد ترابط عكسي مع تركيز الألبومين (r = - 0.104). المجلة الطبية لجامعة البصرة ص33-38

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