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Uric Acid and Endothelial Dysfunction in Essential Hypertension

Authors: Halla G. Al-Gebouri --- Zainab Abdul Razak Al- Sharifi
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2010 Volume: 3 no.3, 4 Issue: 7 Pages: 914-918
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Uric acid (UA) can stimulate the biosynthesis of c-reactive protein (CRP), and that might be one of the mechanisms underlying the endothelial dysfunction. Several studies showed an independent link between UA and CRP suggest that chronic exposure to mild hyperuricemia may be a factor that contributes to micro inflammation and raised CRP in individuals with essential hypertension.
Aim: The aim of this study is to investigate the relationship between the serum uric acid, CRP , total cholesterol and endothelial dysfunction in patient with essential hypertension .
Patients and methods: Twenty patients with essential hypertension and fifteen apparently subjects matched for age and weight have been included in this study, Uric acid and total cholesterol were determined by enzymatic methods. High sensitivity C-reactive protein (HsCRP) enzyme immunoassay for the quantitative determination in human serum was used.
Results: The data obtained showed that the serum levels of uric acid, CRP and total cholesterol were significantly higher in patients with hypertension than in healthy controls.
Conclusion: The conclusion was that hyperuricemia in individuals with essential hypertension is associated with endothelial dysfunction. This association, which is independent of classical risk factors like total cholesterol, CRP, supports the hypothesis that UA plays a significant role in this alteration in humans.

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A study on the Prevalence of Dyslipidemic Disorder Among Residents of Karbala City

Authors: Hedef Dhafir El-Yassin --- Zainab Abdul Razak Al- Sharifi --- Suhair Al-Jeboori
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 358-366
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Dyslipidemia is a common health problem.OBJECTIVE:The present study was to estimate the prevalence of dyslipidemia as defined by the NCEP ATP3 criteria among people living in Karbala city.SUBJECTS AND METHODS:The investigations were performed on a sample of 130 subjects selected arbitrarily from those attending the public clinic in AL- Hussainy teaching hospital in Karbala for consultation and from some subjects accompanying the patients. Fasting blood samples for routine lipid analyses from each subject were obtained after informing them about the project and having their approval.RESULTS:In this sample of subjects it was found that 72.3% of them had a plasma TC level lower than 200mg/dl. This study also determined a prevalence of hypertriglyceridemias in 23.3% of study subjects who have a borderline TG level. The prevalence of high and very high TG among them were 6.9% and 4.4% respectively. The frequency of LDL-C levels above 160 mg/dl was found to be about 1% of the sample. Borderline levels of LDL-C was found in 7.3%of the sample. In the meantime the prevalence of low HDL-C levels in this study was found to be 39.2% of the subjects who had a serum level of HDL-C less than 40mg/dl.CONCLUSION:In conclusion this study demonstrated a very high prevalence of dyslipidemia among Iraqi adult subjects living in Karbala city. A public health strategy for prevention, detection and treatment of this disorder is neede

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