research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Estimation of C3 and C4 Level in non-Pregnant Women with Iron Deficiency Anemia
تقدير مستوى المتممات (سي3 وسي4) لدى النساء غير الحوامل المصابات بفقر دم عوز الحديد

Author: Zainab Wahab Al-Maaroof
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 3 Pages: 662-668
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Background: Iron deficiency is one of the most common nutritional disorders in menstruating women and adolescents. Iron and other micronutrients have immunomodulating functions that influence the susceptibility of a host to infectious diseases. Complement C3 and C4 are the components most frequently measured which are capable of lysis of bacteria or red cells or can opsonize bacteria or cells so that they are phagocytosed. Objective: To determine the level of complements proteins (C3&C4) in adult non-pregnant women with iron deficiency anemia.Patients and methods: A total of 57 young adult non pregnant females were enrolled in this case control study .Serum complements C3 and C4 were evaluated in 32 women with iron deficiency anemia and 25 age matched normal women as a control group. Measurement of complements (C3&C4) was done by using quantitative determination by radial immune diffusion plates.Results: The mean ± standard deviation for C3 &C4 were 95.02± 27.35& 21.03± 9.72 respectively for the group with iron deficiency anemia while for control group was 112.79 ± 32.46 for C3 &26.32 ± 8.38 for C4, with statistically significant differences, p- value 0.0297 for C3 & 0.0034 for C4.Conclusion: Adult non pregnant women with iron deficiency anemia have low level of C3 and C4 in compare to normal adult non pregnant women.

خلفية الدراسة: يعد النقص الحديدي أحد الاضطرابات المغذية الاكثر شيوعا في الدول الصناعية وخصوصا لدى النساء الحائضات والمراهقات. للحديد والمغذيات زهيدة المقدار وظيفة التحوير المناعي والتي تؤثر بسهولة على المضيف للإصابة بالأمراض المعدية. تعد المتممات نوع سي 3 وسي 4 من اكثر المتممات قياسا. ان المتمم نوع سي 3 هو الاكثر وفرة في المصل الانساني ويستعمل كفحص تنظيري. المتمم نوع سي 4 هو الثاني من حيث الوفرة في المصل.الهدف: تحديد مستوى البروتينات المتممة نوع سي 3 وسي 4 لدى النساء البالغات غير الحبلى المصابات بفقر دم عوز الحديد.المرضى و طرق العمل: سجلت 57 شابة انثى غير حبلى في هذه الدراسة من نوع سيطرة الحالة0 تم تقييم المتممات نوع سي 3 وسي مصل 32 امرأة مصابة بفقر دم عوز الحديد و 25 امرأة متناظرة في العمر كمجموعة قياسية. تم قياس المتممات نوع سي 3 وسي 4 باستعمال التقدير الكمي بصحون الانتشار الشعاعية المنيعة.النتائج: كان المتوسط ± الانحراف المعياري للمتممين سي 3 و سي4 هو ( 95.02± 27.35 ) و (21.03 ± 9.72 ) على التوالي لمجموعة المريضات أما للمجموعة القياسية فقد كانت النتائج ( 112.79 ± 32.46) للسي 3 و ( 26.32 ± 8.38 ) للسي 4 مع اختلافات احصائية هامة حيث كانت القيمة التنبؤية للسي 3 (0.0297) وللسي 4 ( 0.0034).الاستنتاجات: للنساء البالغات الحبلى المصابات بفقر دم عوز الحديد مستوى منخفض للمتممين سي 3 وسي4 مقارنة بالنساء الطبيعيات البالغات الحبلى قبل سن اليأس.

Keywords


Article
Evaluation of Leukemia Inhibitory Factor, Interleukin6 and Leptin in Acute and Chronic Myeloid Leukemia in Babylon Province

Authors: Dheyaa Jabbar Yahya --- Zainab Wahab Al- Maaroof --- Abbas Fadhil Hassoon
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 2 Pages: 513 -521
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

Leukemias are a group of diseases described by augmented numbers of white cells in the blood and bone marrow as a result of unregulated clonal proliferation of immature malignant cells .These abnormal white blood cells that not completely developed are called (blasts), or (leukemia cells), The diagnosis of Leukemia was confirmed by blood investigation and by bone marrow biopsy. Leukemia inhibitory factor may play an important role, along with Interleukin-6 and granulocyte colony stimulating factor , in the regulation of early hematopoietic stem cells. Leptin has been implicated in the differentiation and proliferation of hematopotietic cells. In this case control study, we evaluate, the levels of LIF, IL6, Leptin in serum of patients with myeloid leukemia and assess the relationship between leptin level & body mass index in myeloid leukemic patients, in the current study involved 96 individuals; 48 patients with myeloid leukemia and 48 controls. Leukemia inhibitory factor, Interleukin 6 and Leptin levels are measured by ELISA assay in both patient and control groups.The mean LIF,Il6 in the AML and CML groups were significantly higher than control group (p<0.05). while Leptin in the AML and CML groups was significantly lower than control group (p<0.05).And the mean (BMI)in the AML and CML groups were significantly lower than control group (p<0.05).In this study, we conclude thatLIF, IL6 and Leptin play an important role in pathogenesis of Leukemia, LIF, IL6 levels in myeloid leukemic patients more than controls while Leptin level in myeloid leukemic patients less than controls and There is significant relationship between Leptin and body mass index.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2016 (1)

2013 (1)