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Evaluate The Cytokine IL-1α as an Inflammatory Indicator against Isolated Fungi From Patients with Abdominal Pain

Author: Zeana Shaker Al-Hindi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 2 Pages: 497 -503
Publisher: Babylon University جامعة بابل

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Abstract

Acute abdominal pain generally refers to previously undiagnosed pain that arises suddenly and is of less than 48 hours. Fungal infections are considered as one of the most common causes in gastrointestinal disease, but virtually all fungi have been reported to cause infection in immune competent persons as well. Microbiological study was carried on 94 patients having abdominal pain by taking stool and blood from them. At periods from 9-2013 to 2-2014 in General Teaching Hilla Hospital..This study is done to determine the pathogenesis of fungi and the type of immune statue for abdominal pain caused by fungi by estimating concentrations of IL-1α as an immune marker and immuonoglobulins IgG and IgM . The rate of samples that gave positive results for fungal isolate was 60% , while 40%were negative , also the total number of isolated fungi was 12 genera. Cl.cladosporides have a highest rate of isolated fungi was 39.36%,another fungi also appear in stool samples wereCl.nacrosporum20.2% , Al.alternata 13.82% , Candida spp. 11.7%, Cryptococcus 5.31% ,Penicilum2.12% ,Candida albicanus2.12% ,Aspergillus flavas,Aspergillus fumigates ,Candida trubicalis , Candida crusi and Aurobasidium pull in rate 1.06% for each one. Immunological tests to sera of patients with abdominal disorder refer to significance increasing in the concentration of IL-1α for all patients at different age groups, compared to control and the highest concentration of them in the age group 19-26 years (51.371 ± 1.813pg/ml), The immunological study also included measuring the concentrations of each of the serum immunoglobulin IgG and IgM, the concentrations of highest 329 ±83.007, 1388.5 ± 391.645, mg / dL respectively, for different age groups and no significant difference compared with control for IgG while their present in IgM , This study refers to the role of both cellular and humeral immune response through fungal infection with different fungi.Distribute the fungal infection appear in both sex at female60% and male40% .

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