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Article
Assessment of Anxiolytic Activity of Nuts of Prunus Amygdalus Dulcis (Almond) in Mice

Author: Zena Hasan Sahib
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 4 Pages: 817-824
Publisher: Babylon University جامعة بابل

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Abstract

The incidence of anxiety in the community is very high and is associated with lot of morbidity. The most widely prescribed medications for anxiety disorders are the benzodiazepines in which there use are limited by their side effects, hence many herbs employed in traditional and alternate medicine for sleep disorders and related diseases. The nuts of Prunus amygdalus (almond ) are found to possess anti-stress properties, also is an effective health building food, both for the body and the mind. Anxiolytic activity of of Prunus amygdalus dulcis were studied using open-field tests in mice. The efficacy of two doses of Prunus amygdalus dulcis 800 and 1600 mg/kg was compared with standard anxiolytic drug the diazepam (1mg/kg). Both the diazepam and almond (1600 mg/kg) treated groups in this study showed extremely significant increased (p<0.001) in both the number of rearing against the wall and the time spend in central squares with significant increase in the number of crossed squares (p<0.01) and (p<0.05) respectively. The number of grooming was extremely significant decreased (p<0.001) while the duration of grooming showed no significant difference (p>0.05) in compare to the control group. The group that given 800mg/kg of almond showed highly significant decrease (p<0.01) in the number of grooming while the duration of grooming was extremely significant increased (p<0.001) with no significant difference (p>0.05) in the number of rearing against the wall, the time spend in central squares and the number of squares crossed in compare to the control group. These findings suggest that Prunus amygdalus dulcis in a dose 1600 mg/kg possess anxiolytic-like properties equal to that of diazepam while 800mg/kg Prunus amygdalus dulcis has less effect .


Article
Effect of evening primrose oil on primeralary blood coagulation investigation in male rabbits

Authors: Hussien Naji Abdullah --- A.Razzak. A.Latif --- Zena Hasan Sahib
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2011 Volume: 7 Issue: 12 Pages: 47-56
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

This study was performed to determine the effects of Evening primrose oil (EPO) on haemostatic parameters following 30 and 60 days administration of 90 mg/kg (EPO( to healthy male rabbits. The laboratory resulting in significant increase in Prothrombin time (PT), activated partial thromboplastin time (aPTT) assays (p<0.01), platelets count significantly decreased (p<0.01) at both times. While fibrinogen concentration are insignificantly decreased. These effects might be due to inactivation or inhibition of factors affecting coagulation.

هدفت هذه الدراسة لمعرفة تاثير زيت زهرالربيع على معايير التخثربعد 30 و60 يوم من اعطاء 90 ملغمكغم من زيت زهرالربيع لذكور الارانب السليمة .التي نتجت عن زيادة بالغة الاهمية في وقت البروثرومبين ووقت البارشيال ثرومبوبلاستين (p<0.01) وعدد الصفيحات الدموية قل بنسبة بالغة الاهمية (p<0.01) في كلا الوقتين بينما تركيز الفايبرنوجين قل بنسبة غير مهمة . هذه التاثيرات ربما تكون نتيجة هبوط في بعض عوامل التخثر.

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Article
Antidepressant-Like Effect of Rosmarinus officinalis Extract in Male Mice
التأثير المضاد للكآبة لمستخلص إكليل الجبل في ذكور الفئران

Authors: Entisar J. Al Mukhtar --- Selman M. Selman --- Zena Hasan Sahib --- Hamid Naji
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 4 Pages: 803-808
Publisher: Babylon University جامعة بابل

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Abstract

Background: Depression is the most common of the mood disorders. There are many types of antidepressant drugs which have various unwanted effects and interactions.Aim of the study: To explore the potential effects of plants in the treatment of depression in comparison to imipramine. Animals, materials and methods: Twenty eight male Swiss albino mice were divided into four groups (A, B, C, D), each group received distilled water 0.3 ml as a control; imipramine 15 mg/kg; R. officinalis 15 mg/kg and R. officinalis 30 mg/kg PO, once daily for 5 successive days respectively. On the fifth day and after thirty minutes of the treatment administration the mice were tested by using the forced swimming test (FST) and the immobility and swimming times were measured. Results: Water extract of R. officinalis extract (15 mg/kg and 30 mg/kg) high significantly reduced the immobility time and increased the swimming time in the FST in comparison to untreated group, but when compared to imipramine (15mg/kg) it produced similar results. Therefore, water extrat of R. officinalis had antidepressant effects which is comparable to that of impramine in mice.

هدفت هذه الدراسة لمعرفة تأثير المستخلص المائي لأوراق نبات إكليل الجبل كمضاد للكآبة من خلال اختبار السباحة الإجبارية لذكور الفئران. لقد تم إعطاء المستخلص للفئران بجرعتين 15 ملغمكغم و30 ملغمكغم يوميا لمدة خمسة أيام متتالية حيث تم مقارنتهما مع عقار الامبرامين مرة ومع مجموعة لم تأخذ أي علاج مرة أخرى. إن نتائج هذه الدراسة بينت حصول زيادة بالغة الأهمية في وقت السباحة (p<0.01) في حين قل وقت عدم الحركة بنسبة بالغة الأهمية (p<0.01) مما يدل على إن لمستخلص إكليل الجبل تأثير مضاد للكآبة .


Article
Rosemary Leaves Aqueous Extract for Protection against Acute Doxorubicin-Induced Cardiotoxicity in Mice

Authors: Entisar Jawad Al Mukhtar --- Zena Hasan Sahib --- Afraa M. Jawad --- Hamid Naji
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 2 Pages: 385-397
Publisher: Babylon University جامعة بابل

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Abstract

Doxorubicin (DOX) is a cancer chemotherapy widely used to treat a many types of human malignancies, DOX is potent anthracycline antibiotic. As a complicating effect of DOX cardiotoxicity has long been recognized; To explain this cardiotoxicity there are several hypotheses and the most thoroughly investigated one is free radical hypothesis. Our study was designed to investigate if the aqueous extract of rosemary leaves has a protective effect against cardiotoxicity induced by DOX in mice. Twenty eight male Swiss Albino mice were randomly divided into four groups including group1 (negative control), treated with distill water (D.W), group 2 (positive control), treated with 15 mg/kg DOX as a single intraperitoneal (i.p) injection, groups 3 and 4 received 15mg/kg and 30mg/kg respectively of the aqueous extract of Rosmarinus officinalis leaves (ROE) orally (p.o), once daily for 2 weeks, then injected i.p with 15 mg/kg DOX. Two days after DOX or D.W (in control group) injection, animals in all groups were scarified and the levels of the cardiac biomarkers including serum creatine kinase (CK-MB) and serum lactate dehydrogenase (LDH) were measured. Also the cardiac histopathological sections were prepared, stained by hematoxylin and eosin stains and examind under light microscope.The administration of 15mg/kg DOX caused cardiomyopathy which was manifested by extremely significant elevation (p<0.001) in serum CK-MB and LDH levels. In addition, cardiac histopathological sections showed moderate cytoplasm vacuolization and inflammatory cells infiltrate with vascular congestion. Oral administration of 30mg/kg ROE for 2 weeks prior to DOX provided significant protection which was evidenced by extremely significant reduction (p<0.001) in the levels of CK-MB and LDH. Moreover, histopathological sections revealed only mild cytoplasm vacuolization, infiltration of inflammatory cells and vascular congestion in comparison to DOX positive control group (p<0.01). Whereas oral administration of 15mg/kg ROE for 2 weeks prior to DOX showed no significant protection neither in CK-MB and LDH levels, nor in the histopathological sections. Administration of 30mg/kg ROE protect against DOX-induced cardiotoxicity. This might serve as novel adjuvant therapy with DOX.

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