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Prognostic significance of specific proteins and immunoglobulins in sero positive Rheumatoid Arthritis patients

Author: Zina Anwer Salloum Marrow
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2006 Volume: 6 Issue: 2 Pages: 22-26
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Background: Increased levels of specific proteins and Immunoglobulines have been detected in serum from patient with rheumatoid arthritis (RA).Objective: To clarify the clinical significance of specific serum proteins and Immunoglobulin in RA. Methods: Forty- two patients with sero-positive rheumatoid factor (group 1 and 2 according to disease activity progresses) and twenty age- matched healthy subjects were included in the study. Serum total proteins, Protein electrophoresis and Immunoglobulin level were evaluated. Results: Acute phase reactants in RA patients showed a significant increase in comparison to healthy subjects (P < 0.001). There was a significant difference in the levels of α- globulins, γ-Nglobulins, IgG and IgM in group 1 as compared to group 2.Conclusion: The prognostic value of serum specific proteins and Immunoglobulin in patients with RA is high, and can provide some help in predicting the outcome of joint inflammation.

Clinical Evaluation of the Levels of CEA,CA15-3 and Alpha-Feto Protein in Malignant and Benign Pleural Effusion

Authors: Nahla Majeed Tawfiq Al-Sakkal --- Abdul Hammed A. Al-Kassir --- Zina Anwer Salloum Marrow
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 57-62
Publisher: Baghdad University جامعة بغداد


Background: Pleural effusion is a common clinical problem.
Objective: The aim of the study was to evaluate the diagnostic utility of Carcino embryonic antigen (CEA), CA 15- 3, and alpha-feto protein ( AFP ) as a tumor markers in serum and pleural effusion and evaluate the value of combining them as a diagnostic tools that are complementary to cytology in the diagnosis of malignancies .
Methods: Forty patients (18 malignant and 22 benign pleural effusion) were included in this study .The serum and effusion levels of CEA, CA 15 – 3 and AFP were measured using immunoradiometric assay
Results: from the 40 effusions studied 26 were exudates and 14 were transudates. The level of pleural effusions of CEA, CA 15 – 3 and AFP were increased above the cutoffs in 72.5%, 94.4 % and 5.5 % of tested samples with malignancies respectively.
A direct strong significant correlation between serum and pleural fluid CEA, CA 15 – 3 and AFP was noted.
Conclusion: Pleural effusion CEA is the most accurate marker for the diagnostic separation of malignant and benign. The combination of both CEA, CA 15 – 3 improves the sensitivity by up to 11 %.
AFP has no role in the process.
Key words: malignant Pleural effusions, tumor markers, CEA, CA 15 – 3, AFP

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