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Article
Association of Adiponectin Gene Promoter Polymprphism (rs266729) With Ischemic Heart Diseases

Authors: Maha Radhi Abass --- Majid Kadhum Hussain --- Zuhair Mohammed Ali Jeddoa
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3889-3893
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Ischemic Heart Disease is a group of diseases of the blood vessels supplying the heart muscle. Adiponectin is a protein secreted by adipocyte with insulin-sensitizing, Anti-inflammatory and anti-atherogenic properties. Several studies have shown that polymorphisms within the adiponectin gene can be associated with Ischemic heart disease. Aim: The aim of the present study was to evaluate the impact of (rs266729) SNP in the promoter region of the ADIPOQ gene on the occurrence of Ischemic heart disease (IHD).Methods: The study included 150 patients with IHD randomly selected based on World Health Organization (WHO) guideline and 150 as controls group. DNA was extracted from blood and genotyped by PCR-RFLP by using (Hha1) enzyme. Result: The frequency of G allele of rs266729 (C/G) polymorphism was significantly (p=0.0001) in IHD (19.6%) compared with control (13.3%). The homozygous genotype (GG) significantly (0R=1.71, CI 95%=0.65-4.96, P= 0.0001) increased the risk of Ischemic Heart Disease compared with wild type (CC) after adjustment age, sex, and BMI, furthermore the heterozygous (CG) genotype significantly (0R=1.61, CI 95%=0.96-2.87, P= 0.0001) raised the risk of Ischemic Heart Disease.Conclusion: Adiponectin gene polymorphism rs266729 is involved in the pathogenesis Ischemic heart disease.


Article
Immunological Evaluation of Patients with Β-Thalassemia Major in Kerbala City Using Single Radial Immunodiffusion (SRID) Techniqu…………………..………….…

Authors: Zuhair Mohammed Ali Jeddoa --- Sattar jabbar Rahi --- Adel Ateia Abed Ali
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 1 Issue: 9 Pages: 939-943
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Beta-thalassemia major is one of the major health problems in our country. Many studies have confirmed the fact that, these patients have an increased susceptibility to bacterial infections, assumed to be the result of immunological changes.Objective: This study aimed to evaluate some of humoral immunological parameters of thalassemic patients by measuring their serum concentration of Immunoglobulin (IgG), IgM, IgA, and serum complement components C3 and C4.Patients & Methods: A total of forty five beta-thalassemia major patients who wereattending to the thalassemia center in Kerbala teaching pediatrics hospital (24 males and 21females) from January to August of 2009 and fifty of control children with matched age andsex were randomly selected from apparently healthy individuals without any history of recentor recurrent infections, were enrolled in the study. Serum IgG, IgM, IgA, C3 and C4 levelswere measured using Single Radial Immunodiffusion (SRID).Results: The mean of serum IgG, IgM &IgA showed a significant increment (P<0.01) in thalassemic patients as compared with apparently healthy control group, while the serum levels of C3 and C4 were significantly decreased (P<0.01) in thalassemic patients as compared with control group.Conclusion: The elevation of serum levels of studied immunoglobulins can be due to continuous exposure to antigens, repeated infections, and chronic liver disease, while the only probable cause of humoral immune deficiency were found in these patients were due to the decline of serum complement levels (C3 and C4).Recommendations: The determination of serum levels of immunoglobulins and complement components have a beneficial value for evaluation of immunological status of thalassaemia major patients and further work need to be done to evaluate another immunological parameters for example the serum level of cytokines to manipulate the immunological aspects of thalassemic patients.Key word: Beta-Thalassemia major, Immunoglobulin G, IgM, IgA, C3 and C4, (SRID).

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