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Article
possible association of HLA class-1 molecules with rheumatoid arthritis in Iraqi patients

Authors: Amera Al-Nnema --- mustafa Al-Ezzy --- jassim AL-Khafaji --- khalida Al- Mousawy --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2005 Volume: 47 Issue: 3 Pages: 256-258
Publisher: Baghdad University جامعة بغداد

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Article
possible association of HLA class-1 molecules with colorectal cancer in Iraqi patients

Authors: batool H. AL-Ghurabi --- ahmed A. AL-Hassan --- sana'a A.AL-Naseri --- khalida Al- Mousawy
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2006 Volume: 48 Issue: 1 Pages: 48-53
Publisher: Baghdad University جامعة بغداد

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Article
role of liver /kiudney microsomal antibody type 1 with type 2-autoimmune hepatitis

Authors: maan, G,hASSO --- khalida Al- Mousawy --- Eman sh. Al- obeidy, ايمان شاكر العبيدي --- MAKKI-H. FATADH --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2006 Volume: 48 Issue: 2 Pages: 187-189
Publisher: Baghdad University جامعة بغداد

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Article
activation of complements pathways in patients with bachcet's disease

Authors: Ikbal Kh. AL-Joofy اقبال الجوفي --- khalida Al- Mousawy --- raad .K.Muslih --- jassim.Al-Khafaji --- et al.
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2006 Volume: 48 Issue: 2 Pages: 190-193
Publisher: Baghdad University جامعة بغداد

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Article
The Role of Interleukin-8 in Restenosis after Coronary Stent Implantation
دور انترلوكين-8 في عودة التضييق بعد زرع شبكة الشرايين التاجية

Authors: Reem S. Saeed د. ريم سالم سعيد --- Khalida Al-Mousawy د. خالدة الموسوي --- Haithum I. Baqir د. هيثم باقر --- Hilal Al-Saffar د. هلال الصفار
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 3 Pages: 248-252
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract:Background: In-stent restenosis (ISR) is a serious complication of percutaneous coronary intervention (PCI) with stent implantation. Variable factors may interact in the process of ISR. Immuno-inflammatory activity mediated by different cytokines could have a role in the ISR. Among these could be the chemokine, interleukin-(IL-8).Aim of the Study: To assess the role of serum level of interleukin-8 in the process of ISR.Patients & Methods: Forty patients with ISR (diagnosed by coronary angiography) within six months after coronary stenting. Patient control group enrolled 30 subjects who had had coronary stenting with no evidence (by angiography) of ISR .The third group composed of 20 healthy controls.Results &Conclusion: Patients with ISR were mainly above the age of 50 years (62.5%) with male predominance (70%).Interleukin-8 was below detectable level (cut off value=553 pg/ml) in almost all cases with ISR with only 10% of the cases with ISR occur in the outer line values (outside usual range). There was no significant difference in the frequency of detectable IL-8 levels between ISR patients and patient control group (P=0.284), neither between ISR patients and healthy controls (P=0.143). In conclusion, the link between IL-8 and ISR was not found in this study. Key words: Interleukin-8, Restenosis, Coronary stents.

الملخص: استخدم اختبار مترابطة الخميرة بمادة ماصة المناعة/ الطريقة المباشرة للتحري عن نسبة المحرك المناعي للخلايا انترلوكين رقم( 8 ) ل 90 عينة د م تعود إلى 40 مريضا يعانون من عودة التضييق في شبكة الشرايين التاجية بعد بضعة شهور من زرعها, 30 مريضا تمت عملية زرع الشبكة لهم بدون مضاعفات عودة التضييق فيها( المجموعة الضابطة الأولى) و20 حالة من الأصحاء المتطوعين ( المجموعة الضابطة الثانية). أظهرت الدراسة أن نسبة المحرك المناعي رقم 8 في 90% من المرضى المصابين بعودة التضييق بعد زرع الشبكة كانت اقل من المستوى المنظور(أقل من 553 بيكوغرام / مل) وكذلك عدم وجود فرقا ذو دلالة إحصائية واضحة بين مجموعة المرضى المصابين بالتضييق داخل الشبكة والمجموعة الضابطة الاولى (قيمة الاحتمالية =0,284 ) أو مع مجموعة الأصحاء (قيمة الاحتمالية=0,143). لم تثبت الدراسة دورا مهما ل انترلوكين ـ8 في تنشيط التفاعل المناعي في منطقة عودة التضييق.


Article
Immunofluorescen Study of Trophoblastic Bound Immunolglobuline G in preeclamptic women at term

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SummaryBackground: The role of humoral immunity in the pathogenesis of PET is well known so that an altered immune response could be the cause of this disease . Objectives: to evaluate the rule ofplacenta _ bound IgG in the pathogenesis of PET. Methods: 31 pregnant women were included in this study delivered by cesarean section at Baghdad Teaching Hospital , 16 of them were diagnosed and treated for PET. while the rest 15 cases were of normal women of using direct immunoflorescnt test, the level of IgG was detected.Result: Tthe study showed a significant higher level of IgG in the placental biopsy of PET cases than those of control group using ttest, (P<0.025),Conclusion: Trophoblastic bound IgG plays an important role in the pathogenesis of PET as a part of altered humoral immune response against placental tissue in those patients.Key words: PET: preeclampsia, IgG: immunoglobuline. BP: blood pressure


Article
HLA-DR and DQ Antigens in Iraqi Patients with Behget's Disease

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Summary:Background: Behqet's disease (BD) is a multisystemic in inflammatoty disorder, disease onset is believed to be triggered by many factors with a particular genetic background. The aim of this study is to investigate the possible correlation between HLA-DR & DQ antigens and onset of this mysterious disease.Method: By using microlymphocytoxicity test, the frequencies of 18 HLA-DR & DQ antigens were calculated in 65 patient with BD compared with 32 patients control with recurrent oral ulcers (ROU) & 115 healthy control.Results: Significant increased trend of HLA-DR52, DR53 and DQ3 antigens (P<0.001), and significant reduced frequencies of DQ4 antigen (P<0.01) in patient with BD as compared to H.C. group, on the other hand significant decreased DR1 antigen in patient with BD (P<0.005) as compared with patients with ROU.Conclusion: Higher frequency of DR52, DR53 & DQ3, these alleles could in one way or another play a crucial role in susceptibility to BD. Whereas DR1 DQ4 phenotypes decrease the risk to develop, this disease.Key words: Behget's disease, HLA- typing HLA-DR and DQ.

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