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Variation in Immunohistochemical Expression of Neuropilin1 among Oral, Laryngeal and Skin SCC

Authors: Khaled J Abed --- Wassan H Younis وسن حمدي يونس
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2017 Volume: 29 Issue: 1 Pages: 63-69
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Neuropilin 1(NRP1) is considered a novel non - tyrosine kinase co- receptor for the vascular endothelial growth factors (VEGF). First discovered on migrating neurons. NRP1is suggested to be up-regulated in cells of different types of cancer and implicated with advanced disease. The aim of this study was to investigate the variation in expression of NRP1 in oral, laryngeal and skin squamous cell carcinoma.Materials and methods: Tissue sections from 120 formalin fixed- paraffin embedded blocks histopathologically diagnosed as oral, laryngeal and skin SCC (40 blocks for each),immunohistohemically stained in immunoperoxidase method with monoclonal antibodies to NRP1, the localization of expression was examined and the resulting scores were analyzed according to age, sex, and histopathological grades.Results: The immunohistochemical analysis revealed that the NRP1 expression in oral, laryngeal and skin squamous cell carcinoma was (87.5%), (92.2%) and (82.5%) respectively, with no significant variation in expression among them(P=0.44), but, NRP1 up-regulation in all the three types correlated positively with degree of differentiation (P=0.009), (P=0.002) and (P=0.007) respectively.Conclusion: Angiogenesis play an important and similar role in carcinogenesis of oral, laryngeal and skin squamous cell carcinoma, and NRP1 is significantly associated with degree of differentiation in the three types of carcinomaso it can be act as a prognostic marker


Article
Immunohistochemical Coexpression of VEGF and CD34 in Ameloblastoma

Authors: Alaa G. Hussein* MSC (path), FICMS (path --- Balkees T.Garib --- wassan H. Younis
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2008 Volume: 50 Issue: 1 Pages: 42-49
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Angiogenic potential m most tumors; characterized by VEGF and vascular bed densityaround tumor islands, is believed to be an important marker in predicting tumor growth,recurrence and metastasis.Materials and Methods:The study included 50 cases of ameloblastomas. From each case 4 μm sections werestained IHC with antivascular endothelial growth factor antibody- and endothelial linedvessels anti CD34 antibody to evaluate their expression and intensity in relation to theirFac Med Baghdad clinicopathological features.2008 ; Vol.50 ,No.Results:Generally, VEGF was significantly highly expressed with strong intensity in outer celllayer of tumor islands, and the newly formed blood vessels were significantlypredominantly rounded and small in size in comparison to dental folicale and papilla oftooth germ. Young aged patients (≤ 20yrs) had highest mean MvD around tumor islands(35.9). Regarding WHO classification; follicular, plexiform and lining cells in UAB hadhigher expression then acanthomatous and types, but 67% of those in plexiform were ofmoderate intensity. There was no significant differences in mean MvD in all histologicalsolid subtypes, and characterized by round and small vessels. Except those in plexiform,they were elongated and medium. UAB had significant lower microvessel count aroundlining tumor cells (but not around mural growth) and more percentage of elongated mediumsized vessels than follicular but less than plexiform. There was significant correlationbetween VEGF expression and the shape of microvessels. Considering differentmorphological cellular pattern, basal cells showed the highest VEGF positivity and intensity(87.5).1Received Sept. 2006Conclusions:The present study indicate the usefulness of the VEGF expression and MvD inexplaining the aggressive, locally invasive biological behavior of ameloblastoma. The highangiogenic potential is enhancing tumor cell survival and the increase in the production ofnew blood vessels formation is facilitating tumor growth, and by time will enhance theproliferation potential of the incompletely removed surviving tumor islands, so increasingthe chance of ameloblastoma recurrence.

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Article
Immunohistochemical coexpression of VEGF and CD34 in ameloblastoma

Authors: Dr. Ala’a G. Hussein .** د. الاء حسين --- Dr. Balkees T. Garib.* د.بلقيس طه --- Dr. Wassan H. Younis.* د. وسن يونس
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2006 Volume: 3 Issue: 4 Pages: 318-326
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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