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Article
Effect of metformin on pregnancy outcomes in women with PCOS

Authors: Asma A. Swadi اسماء عبد الجليل سوادي --- Saba M.Swadi صبا مطشر سوادي
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2014 Volume: 10 Issue: 17 Pages: 187-195
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Background: Recurrent pregnancy loss (RPL) classically refers to the occurrence of three or more consecutive losses of clinically recognized pregnancies prior to the 20th week of gestation (ectopic, molar, and biochemical pregnancies are not included). we hypothesized that metformin owing to its metabolic, endocrine effect may reduce the incidence of first trimester miscarriage in PCOS women.Materials and Methods: We examined the records of all 82 nondiabetic women with the polycystic ovary syndrome who became pregnant while being seen in the out patients Clinic of the maternity teaching hospital and private clinic in AL-Qadisyiah city between January 2011 and march 2014, and who did receive metformin 3 months pre-conception (group1; n = 37) in contrast to second group who became pregnant while taking metformin and continued taking metformin at a dose of 1000–2000 mg daily throughout the first 20 weeks of gestation(group2; n = 45). Results: both groups were similar with respect to all background characteristics (age, BMI, parity, RBS, blood urea and serum creatinin).rates of early pregnancy loss in group1(82.5%) compared with (79.7%) in group2.after administration of metformin; pregnancy loss was( 83.7%,15.5%) in group1 and group2 respectively (P value = 0.001).Conclusion: administration of metformin in the first 20 weeks of pregnancy to women with PCOS was associated with a marked and significant reduction in the rate of early pregnancy loss.

أجريت هذه الدراسة على مجموعه من النساء المصابات بمتلازمة تكيس المبايض واللاتي تعرضن الى حالة فقدان حمل متكرر(اجهاض متكرر).82 امراه مصابه بمتلازمة تكيس المبايض وغير مصابات بداء السكري تم تقسيمهم الى مجموعتين (المجموعه1)وعددها 38 اعطيت عقار الميتفورمين لمدة 3 اشهر قبل الحمل وتم ايقافه عند حدوث الحمل مباشرة. اما (المجموعه2) وعددها 45 اعطيت عقار الميتفورمين لمدة 3 اشهر قبل الحمل واستمرت باخد العقار 4 اشهر بعد حدوث الحمل.النتائج:الجموعه الاولى كانت نسبة الاجهاض المتكرر فيها = 83.78% مقارنة بالمجموعه الثانيه التي استمرت باخد العقار 4 اشهر بعد حدوث الحمل حيث اصبحت نسبة الاجهاض= 15.5% . نستنتج بان استمرار استخدام عقار الميتفورمين لمدة 4 اشهر بعد الحمل يقلل من نسبة الاجهاض المتكرر وبشكل ملحوظ (p=0.001)

Keywords

PCOS --- BMI


Article
Evaluation of the Relation between Asthma, Obesity and Leptin Level in Iraqi Asthmatic Patients and the Main Risk Factors that are Associated with Leptin Level

Author: Hiba A. Hasan
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 2 Pages: 96-101
Publisher: Baghdad University جامعة بغداد

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Abstract

This study tries to clear the correlation and association between asthma, obesity and leptin levels. Also it will work to indicate the main risk factors which play role in the elevation of leptin level within asthmatic patients. This is a case control study conducted on (38) asthmatic patients and (20) healthy control who were closely similar by age, gender and BMI. The main statistical tests used were student t test, linear regression test and correlation test. Significance was set at P < 0.05. Sampling method used for this study was convenience sampling method. The main results of this study show a significant association and positive correlation between age (old age &#8805; 40 years old), female gender, BMI (overweight and obese) and steroid utilization with leptin elevation in Iraqi asthmatic patients since P values < 0.05. This study concludes that there is a correlation between obesity, age, sex and utilization of steroid with leptin level and they were the main risk factors which play role in the mechanism of elevation of leptin in Iraqi asthmatic patients.

تھدف ھذه الدراسة على إیجاد العلاقة بین الربو و السمنة و مستوى اللبتین و تحدید عوامل الخطورة الاساسیھ التي تلعب دوراًفي ارتفاع مستوى اللبتین عند المرضى المصابین بالربو . تشتمل ھذه الدراسة على ( 38 ) مریضاً مصاباً بالربو و ( 20 ) من الأشخاصاختبار الارتداد ,t الأصحاء المتقاربین بكل من العمر و الجنس و كتلھ الجسم. التحلیل الإحصائي المستخدم في ھذه الدراسة ھو اختبارتعتبر الزیادة معنویة. طریقھ جمع العینات كانت بواسطة طریقھ الاختیار المریح. كانت p< الخطي و اختبار العلاقة. إذا كانت 0,05بین العمر (اكبر من او یساوي 40 ), الإناث, كتلھ الجسم (الوزن الزائد و p< النتائج الاساسیھ لھذه الدراسة ھي علاقة معنویة 0,05البدین) و استھلاك الستیروید مع مستوى اللبتین عند المرضى العراقیین المصابین بالربو.تستنتج ھذه الدراسة بان ھناك علاقة بینالسمنة, العمر, الجنس, استھلاك الستیروید و زیادة مستوى اللبتین عند المرضى المصابین بالربو و تعتبر من عوامل الخطورةالاساسیھ التي تلعب دوراً في میكانیكیھ زیادة ھرمون اللبتین عند المرضى العراقیین المصابین بالربو.

Keywords

Leptin --- Asthma --- BMI.


Article
Obesity and Asthma Severity Among Adults Presenting to the Out Patient Clinic

Author: Hashim M. Al-Kadhimi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 2 Pages: 205-210
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Recent studies have suggested a relationship between asthma and obesity. The risk for developing asthma increases with increasing obesity among individuals. Yet little is known about how obesity influences asthma.OBJECTIVE: To determine whether a relation of Obesity to asthma exists among adults presenting to the out patient respiratory clinic , and the correlation between Obesity and spirometric changes in patients with asthma. METHODS: A cross-sectional study was done for one hundred patients aged 17 to 70 years patients with asthma diagnosed by clinical and pulmonary function test , in the respiratory outpatient's clinic in AL Kadhmia Teaching Hospital.Collected from May to December 2010 The following parameters were assessed:Weight, height, body mass index, gender,spirometric parameters which includes of forced expiratory volume in 1 second (FEV1), forced vital capacity(FVC),FEV1FVC ratio, and forced expiratory flow50% (FEF50%)RESULTS:There were 100 asthmatic patients,32 male and 68 female. There age between 17-70 year, classified into four groups according to BMI. There was significant relation between obesity and asthma (p=0.03),this relation was statistically significant in female(p=0.003) but not in male.spirometry in male showed no statistically significant (p-value > 0.05) for FEV1, FVC FEV1FVC ratio, FEF50% in both non obese and obese, but in female statistically significant for FEV1FVC(p 0.05) ,FEF50% (p 0.036) , while no statistically significant for FEV1, FVC in both groups, for both male and female according to BMI there is statistically significant for FEF50% (p 0.015),while no statistically significant for FEV1FVC, FVC, FEV1 in both groups.CONCLUSION:There was a significant relation between asthma and obesity , in female ,but not in male. There is statistically significant difference for FEF50% ,and FEV1FVC in obese female .Also there is statistically significant difference for FEF50% in both male and female according to BMI.

Keywords

asthma --- obesity --- BMI


Article
Obesity and Overweight among Medical Teachers in College of Medicine in university of Kufa

Author: *Salam Jasim Mohammed, FIBMS. *Huda Ghazi Hamid, FIBMS.
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2012 Volume: 15 Issue: 1 Pages: 279-285
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objective: this study was conducted to determine the prevalence of obesity and overweight and some associated factors among teachers in medical college in Kufa university.Design and methods: A cross sectional study on obesity and overweight covering 96 medical teachers in medical college in Kufa university was carried out during the period 1st of April to 1st of august 2011, data collection done by using questionnaire and measurement of weight and height by using weight display instrument which is present in community medicine departmentResults : results of this study shows that there is 36.5% of participants suffering from overweight and 18.8% suffering from obesity.In the current study no significant association between sex and body mass index (BMI) (P=0.417) and also no significant association between BMI and obesity in first degree relatives (P=0.944).This study shows no significant association between BMI and having chronic disease (P=0.856).This study shows significant association between BMI and number of meals taken between the main meals (P=0.024) also significant association between BMI and exercise (P=0.023)Conclusion: the results show that the problem is big among this group of community and the need to change their lifestyle from sedentary lifestyle to more active one and change dietary habits and establish a center for exercise inside the university and encourage all medical teachers to participate in it.

أجريت هذه الدراسة لمعرفة مدى انتشار زيادة الوزن والسمنة لمجموعة من اساتذة كلية الطب في جامعة الكوفة وبعض العوامل المساعدة على ذلك. ولهذا الغرض تم اجراء دراسة مسحية مقطعية شملت 96 استاذ في كلية الطب للفترة من الاول اربيل الى الاول من آب 2011. تم جمع المعلومات من الاساتذة من خلال استمارة تحتوي على مجموعة من الاسئلة متعلقة بالموضوع قيد البحث كذلك تمت عملية قياس الطول والوزن من خلال جهاز متخصص موجود في قسم طب المجتمع. نتائج هذه الدراسة اظهرت ان 36.5% من المشاركين يعانون من زيادة الوزن بينما 18.8% يعانون من السمنة .هذه الدراسة اظهرت انه لا توجد علاقة بين الجنس و مؤشر كتلة الجسم ( P=0.417) كذلك لا توجد علاقة بين مؤشر كتلة الجسم والسمنة لدى الاقارب من الدرجة الاولى (P=0.944) .كذلك لا توجد علاقة بين مؤشر كتلة الجسم ووجود مرض مزمن لدى الاستاذ.اظهرت هذه الدراسة انه هنالك علاقة بين الوجبات التي يتم تناولها بين الوجبات الرئيسية ومؤشر كتلة الجسم(P=0.024) كذلك هنالك علاقة بين مؤشر كتلة الجسم و التمارين الرياضية التي يمارسها الاستاذ.هذه الدراسة بينت ان حجم المشكلة كبير لدى هذه الشريحة من المجتمع والحاجة لتغيير نمط حياتهم من حياة الخمول الى حياة ذات حركة اكثر وكذلك تغيير طبيعة الغذاء .كذلك الدعوة الى بناء مركز رياضي داخل الجامعة وتشجيع الاساتذة على ممارسة الرياضة في اوقات الفراغ.

Keywords

obesity --- overweight --- BMI


Article
Gingival Health and Alveolar Bone Loss Among Iraqi Overweight Primary School - Age Pupils (Radiographic Study)

Author: Sanaa J. AL-Qasab
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2014 Volume: 3 Issue: 1 Pages: 101-106
Publisher: Tikrit University جامعة تكريت

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Abstract

Many studies have found a strong association between obesity and various clinical and radiographical aspects of periodontal disease, most of these studies were directed toward adult age group only, while younger ages were omitted. To provide radiographic data about the effect of overweight on periodontal health status among Iraqi primary school-age pupils.The sample of this research was consist of 90 pupils of both gender (45 girls and 45 boys) with age range (6-12)years. All were examined clinically for bleeding on probing (BOP) and radiographically for alveolar bone loss (ABL). According to their percentile ranking the pupils in each gender group were divided into 3 subgroups (healthy weight, at risk of overweight and overweight). each subgroup was consist of (15 child). Greater mean values for BOP index were recorded for pupils in overweight group (0.8 for girls and 0.66 for boys) in comparison to those in healthy (0.26 for girls and 0.46 for boys) and at risk (0.4 for girls and 0.46 for boys), also greater mean values for ABL radiographically were recorded for pupils in overweight groups (1.53 mm for girls and 1.66 mm for boys) in comparison to those healthy (1.00 mm for girls and 0.8 mm for boys) and at risk (1.06 mm for girls and 1.46 mm for boys). According to paired t- test most of these differences were found to be statistically significant. On the other hand, No significant difference were recorded between different study groups on gender basis. There is a clear relation between obesity and periodontal health on both clinical and radiographical examinations.

Keywords

obesity --- bmi --- bop --- abl.


Article
Caries Experience in Relation to Weight Status among School Children Age 7-12 Year-old in Tikrit City

Author: Azhar A. Al-Kamal.
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2016 Volume: 4 Issue: 1 Pages: 16-21
Publisher: Tikrit University جامعة تكريت

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Abstract

Caries is an infectious disease that is induced by the diet. Despite its decline in all age group on a worldwide basis, it is still a serious public health problem in children and its control should be a priority. It has demonstrated that dental caries can gradual reduce children's weight gain, which may be reversed after complete oral rehabilitation. The aim of this study was to investigate the association between age-specific body mass index (BMI-for-age) and dental caries among school children 7-12 years in Tikrit city.Material and method: A random sample of 390 school going healthy children aged 7-12 years were selected from different schools located in the Tikrit city. Height and weight for each child was recorded to obtain BMI-for- age. Dental caries was recorded (dmft, dmfs, DMFT and DMFS) according to WHO criteria. The data obtained was subjected to statistical analysis.The results showed that the underweight children were more likely to have caries experience than normal and overweight children for primary dentition (dmft 6.75 ± 0.56 and dmfs 17.21± 1.37) and for permanent dentition (DMFT 4.00 ± 0.58 and DMFS 6.48 ±1.23) with statistically no significant differences between the three groups.

Keywords

Underweight --- Overweight --- BMI --- WHO


Article
Association between Interleukin-5 & Body Mass Index among Iraqi Asthmatic Patients

Authors: Wala'a E. Jasim --- Batool A. Al-Haidary --- Yacoob Y. Al-Rubayei
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 116-120
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Asthma is an allergic hypersensitivity disease in which many mediators play a role in its pathogenecity. One of these etiological agents is the mediators such as Interleukin-5 (IL-5). The aim of this study to demonstrate the association between IL-5 and obesity in asthma development. Materials & Methods: One hundred and four sera samples for asthma cases have been studied in comparison with 41 non-asthmatic bronchitis as a patient controls beside 30 apparently healthy controls. Cytokine has been estimated using ELISA method in correlation with Body Mass Index (BMI). Results: This study revealed a significant correlation between IL-5 concentration and BMI (P<0.05), particularly among females. Conclusion: There is certain correlation between obesity and asthma accompanied by IL-5. Key

Keywords

Asthma --- IL-5 --- ELISA --- BMI.


Article
Effect of leptin level in non insulin dependant (type 2) obese diabetic subjects

Authors: Othman G. Othman --- Maysaa J. Majeed
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 1 Pages: 76-80
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Determine how do obesity and type2 diabetes intertwined? and what it takes to turn an obese person into a person with diabetes. That link may help to understand why some obese people never develop diabetes while many others do.Serum sugar level was used as indicator of insulin level; leptin level was used as indicator of leptin resistance.A total of 50 obese subjects were involved in this study, 25 obese subject (BMI >30) had diabetes mellitus type 2(no insulin dependant), selected from Baghdad teaching Hospital in Baghdad /Iraq. The remaining 25 obese (BMI >30) were normal healthy individuals.Patients and Methods: ELSA technique was used for the measurement of serum leptin. Blood sugar was determined by using colorimetric method. Data were expressed as mean ± SD results and were evaluated using the student t-test for paired data. Conventional methods were used for the correlation and regression analyses.Results: Obtained results showed that the level of serum leptin in healthy obese subjects were significantly lower than that of obese diabetes subjects. , serum sugar in non diabetic obese subjects was significantly lower than obese diabetes type2 subjects.Serum leptin correlated negatively with level of serum sugar at the same time had a positive correlation with BMI in non diabetic obese group whereas level of serum leptin correlated positively with each of BMI and serum sugar in diabetic type2 group. All results are thoroughly discussed in the text.Conclusion: The present study indicates the possibility of future development of a new class of anti diabetic agents that act centrally and independent of insulin action.


Article
The Lipid Profile in Children with Type 1 Diabetes Mellitus in Erbil Governorate

Authors: Abbas A. Alrabaty --- Abdulkader A. Alnakshabandi --- Nazar B. Yahya
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 4 Pages: 344-349
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Diabetes Mellitus is the most common endocrine-metabolic disease in children. Diabetic patients with hyperlipidemia frequently develop atherosclerosis which is an important cause of morbidity and mortality.OBJECTIVE:The aim of this study was to evaluate serum lipids total serum cholesterol, total serum triglyceride (TGs), High density lipoprotein (HDL-C), Low density lipoprotein (LDL-C) and very low density lipoprotein (VLDL-C) in children with type-1 diabetes mellitus in comparison with controls, and to determine the relationship of lipid profile with gender, body mass index (BMI) and duration of diabetes among patients.METHODS:In this case-control study, the lipid profiles of 52 patients aged 6-18 years (27 males 25 females) with established type 1 diabetes were compared with those of 52 healthy controls of the same age and gender from the first of December 2007 to the 29th of February 2008.RESULTS:The lipid profiles of patients with type 1 diabetes mellitus showed the following values, the mean total serum cholesterol 175 ± 55 mg/dl, total serum TGs 140 ± 135 mg/dl, HDL-C 59 ± 19 mg/dl, LDL-C 93 ± 51 mg/dl and that of VLDL-C 23 ± 13 mg/dl, whereas for the controls they were 136 ± 34 mg/dl, 74 ± 25 mg/dl, 53 ± 15 mg/dl, 68 ± 30 mg/dl and 15 ± 5 mg/dl respectively.CONCLUSION:The abnormalities in lipid profile regarding total serum cholesterol, total serum TGs, LDL-C and VLDL-C showed that they were significantly higher in diabetic patients than in control group, while HDL-C although it was higher among diabetic patients, but it was not statistically significant. Total serum TGs was significantly increased with the duration of diabetes.


Article
The Study Of Relation Between Some Of Sexual Hormones And Body Mass Index For Infertile Patients
دراسة العلاقة بين بعض الهرمونات الجنسية ومعامل كتلة الجسم للمرضى المصابين بالعقم

Author: Samah Amer Hammood Al-Obaidi
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2014 Volume: 4 Issue: 2 Pages: 175-182
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objective: The study aims to clarifying the role of the Body Mass Index on range of hormones for oligoasthenioteratospermia infertility patients in men.Methodology: Out of (65) specimens of blood collected from patients suffering of different type of infertility ,the age of patients (28-50year). In Fertility Center Laboratories Al – Sadder Medical City at Al-Najaf Province , study period was between 1/7/2012 to 1/10/2012. Results: The results of the study sample have revealed that an increase of percent of BMI in increased age with increased of hormone dysfunction. The study results had revealed significant decrease (P<0.05) of sex hormone ( LH ,FSH, Testosterone) negative relationship, and significant increased of prolactin hormones when the BMI increased which revealed positive relationship. Conclusions: It can be concluded that BMI correlated (negative) with range of sexual and asexual hormone through increase of infertility men percent.Recommendations: The available data recommended to be complemented by future cohort studies that define prospectively the extent of this relationship and examine the effect of weight loss in patients suffering from over weight (infertile) and effect it on sexual hormone, besides their increase community awareness about the risks of epidemic of increase weight and infertility by conducting seminars and educational programmers for reduce obesity.

الهدف : هدفت الدراسة إلى توضيح تأثير معامل كتلة الجسم وعلاقتها بمستويات بعض الهرمونات للأشخاص العقيمين بقلة وضعف وتشوه النطف من الرجال . المنهجية : جمعت خلال هذه الدراسة (65) عينة دم من أشخاص مصابين بأنواع مختلفة من العقم وتم عمل لها الطرد المركزي للحصول على المصل وكان معدل أعمارهم تتراوح بين ( 28-50 سنة ) في مختبرات مركز الخصوبة / مدينة الصدر الطبية / محافظة النجف الاشرف للفترة مابين 1/7 ولغاية 1/10/2012 م . النتائج: أوضحت نتائج دراسة العينات زيادة نسبة معامل كتلة الجسم والعمر مع زيادة الاضطراب في نسبة الهرمونات المقاسة .وبينت نتائج الدراسة انخفاض معنوي ( P<0.05) في نسبة معامل كتلة الجسم مع تقدم العمر و زيادة في اختلال الهرمونات ( التيستوستيرون و الهرمون المحفز للجريبات والهرمون اللوتيني ) حيث وجدت العلاقة ارتباطيه سالبة. أوضحت نتائج الدراسة زيادة معنوية ( P<0.05) في تركيز هرمون الحليب مع زيادة معامل كتلة الجسم المتمثل (( بفوق الوزن الطبيعي )) مع وجود علاقة عكسية رابطة بينهما . الاستنتاجات: يستنتج من هذه الدراسة بأنه يمكن أن يؤثر معامل كتلة الجسم (سلبياً) بمستويات الهرمونات الجنسية وغير الجنسية .وزيادة نسبة الرجال المصابين بالعقم . التوصيات :نوصي من خلال الدراسة الحالية إلى التعرف على العلاقة بين تخفيض الوزن في الأشخاص ذو الوزن فوق الوزن الطبيعي وتأثير ذلك على فحص الهرمونات وخصوبة الرجال،فضلا عن زيادة التوعية حول مخاطر زيادة الوزن وعدم الخصوبة عن طريق إجراء الندوات والبرامج التثقيفية للوقاية من السمنة .

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