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Article
Rota virus Association diarrhea among children less than 5 years in Mosul city
علاقة الاسهال بفايروس الدوار البشري بين الاطفال الاقل من خمس سنوات في مدينة الموصل

Author: Nadya Ebraheem Salih نادية ابراهيم صالح
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2009 Volume: 14 Issue: 3 Pages: 76-80
Publisher: Tikrit University جامعة تكريت

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Abstract

In a survey of rotavirus induced diarrhea in 150 child less than 5 years referred to Ibn-Al-Atheer pediatric Hospital in Mosul city from 5th July 2007 to 5th August 2007. The stool specimens were investigated by Latex agglutination test (slidex – Rota kit, France) for the presence of RV antigen. The incidence of RV infection among children hospitalized with acute diarrhea was studied . Rotavirus was detected in 28.7% (43/47) of children with acute diarrhea. The peak incidence of RV diarrhea was seen in children aged 25-36 months (40%), furthermore, the present study shows the impact of different demographic variables on the positivety of rotavirus among children.

تضمنت الدراسة لفايروس الدوار البشري المسبب للاسهال لدى150 طفل بعمر اقل من خمسة سنوات والراقدين في مستشفى ابن الأثير للأطفال في مدينة الموصل للفترة من الخامس من حزيران2007 وحتى الخامس من اب 2007 وكذلك التحري عن وجود حمة الدوار في نماذج البراز بأستخدام فحص التلازن (لاتكس). ان نسبة الاصابة بحمة الدوار في الاطفال دون سن الخامسة والذين يعانون من اعراض الاسهال الحاد هي28,7 %.وان قمة حدوث الاصابة بحمة الدوار كانت في عمر25-36 شهر(40 %). بالاضافة الى ذلك اظهرت الدراسة الاصابة بحمة الدوار وعلاقتها بالعديد من المتغيرات.

Keywords

diarrhea --- Rotavirus


Article
Anti-rotavirus IgG Seropositivity among Healthy Population and Patients with Acute Diarrhea in Baquba-Diyala Province
مدى وجود اضداد فايروس الاسهال روتا بين الاصحاء مقارنة بالاطفال المصابين بالاسهال الحاد

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Abstract

Background: Rotavirus infection is the leading single cause of severe diarrhea among infants and young children. More than 500,000 children under 5 years of age die from rotavirus infection each year, and almost 2 million more become severely ill. Objectives: To determine the rate of anti-rotavirus IgG antibody among healthy population and patients with diarrhea in Baquba- Diyala province. Materials & Methods: The present study was extended from the first of July 2008 to the first of September/ 2009 in Baquba City. A total of 300 fecal specimens were collected from patients suffering from acute diarrhea. The patients include 136 (45.3%) females with mean age (7.8 ± 4.7) years, and 164 males with mean age (5.3± 3.4) years. Biorad-Rota kit is a highly sensitive agglutination test was used for detection of rotavirus in fecal specimens. Anti-rotavirus IgG antibody was detected by ELISA technique. All data were statistically analyzed Results: The results revealed that the anti-rotavirus IgG antibody positivity rate among patients was 49.3% compared to 37.1% among the healthy population. Additionally, 25.7% of patients who were positive for rotavirus infection as detected by agglutination test in the stool were also positive for anti-rotavirus IgG antibody. On the other hand, 17(22.4%) of patients with rotavirus diarrhea were negative for anti-rotavirus IgG antibody. The effects of age, gender, residence, type of water supply, and type of feeding on the frequency of anti-rotavirus IgG antibody in both patients and healthy groups were statistically insignificant.Conclusion: Nearly two third of healthy population in Baquba city are liable for rotavirus infection as they lack anti-rotavirus IgG antibody.Keywords: Rotavirus, acute diarrhea, Anti-rotavirus IgG.


Article
The Prevalence of Rotavirus Infection in Baquba- Diyala Province

Authors: Mehdi SH. AL-Zuheiry --- Abbas A. Al-Duliami --- Abdul-Razak SH. Hasan --- Abdul-Kadir Y. Al-Azawi
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2010 Volume: 6 Issue: 3 Pages: 16-27
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Rotavirus infection is the leading single cause of severe diarrhea among infants and young children. More than 500,000 children under 5 years of age die from rotavirus infection each year, and almost 2 million more become severely ill.Objectives: To determine the prevalence of rotavirus infection among patients with diarrhea in Baquba- Diyala province, and to explore the effect of certain relevant factors.Materials and methods: The present study was extended from 1/July/2007 to 1/September/ 2008 in Baquba city. A total of 300 fecal specimens were collected from patients suffering from acute diarrhea. The patients include 136 (45.3%) females with mean age (7.8 ± 4.7) years, and 164 males with mean age (5.3± 3.4) years. BioRad-Rota kit is a highly sensitive agglutination test was used for detection of rotavirus in fecal specimens. Bacterial co-infections were identified by culturing on differential and selective media, and the final diagnosis followed the standard bacteriological criteria. Parasitic co-infections were detected by general stool examination. All data were statistically analyzed.Results: The results showed that the overall infection rate by rotavirus among patients was 20.3%, and the highest infection rate was among those below 5 years of age. Rotavirus infection among adult patients was also recorded. Females had an insignificantly higher infection rate compared to males (22.1% vs. 18.9%). Patients consuming river's water had significantly higher infection rate compared to those used municipal or tank water (34.5%, 14.1% and 18.5%) respectively. Patients (below 2 years) feed artificially had higher infection rate com College of Vet. Med. Diyala University pared to those on breast or mixed feeding (28.2%, 19.1% and 18.8%) respectively. Although, the rotavirus infections were recorded around the year, the highest infection rate was during spring and winter seasons (22.5% vs 21.4%). It was also found that neither bacterial nor parasitic co-infections were significantly associated with rotavirus infection.Conclusion: Rotavirus infection as a cause of acute diarrhea was common in Diyala province, and particularly affects children below 5 years of age.


Article
The Prevalence of Rotavirus Infection in Baquba - Diyala Province
معدل الاصابة بالفيروس العجلي في مدينة بعقوبة- محافظة ديالى

Author: Abdul-Razak Sh. Hasan د.عبدالرزاق شفيق حسن
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2011 Volume: 24 Issue: 3 Pages: 200-204
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Rotavirus infection is the leading single cause of severe diarrhea among infants and young children. More than 500,000 children under 5 years of age die from rotavirus infection each year, and almost 2 million more become severely ill.Objectives: To determine the prevalence of rotavirus infection among patients with diarrhea in Baquba- Diyala province, and to explore the effect of certain relevant factors.Materials and methods: The present study was extended from 1/July/2007 to 1/September/ 2008 in Baquba city. A total of 300 fecal specimens were collected from patients suffering from acute diarrhea. The patients include 136 (45.3%) females with mean age (7.8 ± 4.7) years, and 164 males with mean age (5.3± 3.4) years. Demographic information regarding the patient's age, sex, residence, type of water supply, and type of feeding (for those below 2 years of age) were collected through a special questionnaire prepared for this study. BioRad-Rota kit is a highly sensitive agglutination test was used for detection of rotavirus in fecal specimens. All data were statistically analyzed.Results: The results showed that the overall infection rate by rotavirus among patients was 20.3%, and the highest infection rate was among those below 5 years of age. Rotavirus infection among adult patients was also recorded. Females had an insignificantly higher infection rate compared to males (22.1% vs. 18.9%). Patients consuming river's water had significantly higher infection rate compared to those used municipal or tank water (34.5%, 14.1% and 18.5%) respectively. Patients (below 2 years) feed artificially had higher infection rate compared to those on breast or mixed feeding (28.2%, 19.1% and 18.8%) respectively. Although, the rotavirus infections were recorded around the year, the highest infection rate was during spring and winter seasons (22.5% vs. 21.4%).Conclusion: Rotavirus infection as a cause of acute diarrhea was common in Baquba, and particularly affects children below 5 years of age. Keywords: Rotavirus, acute diarrhea, gastroenteritis

تمهيد: يعتبر الفيروس العجلي المسبب الرئيسي الوحيد لحالات الإسهال الشديدة لدى الرضع والأطفال يبلغ عدد الوفيات لدى الأطفال تحت سن الخامسة من العمر من جراء الإصابة بهذا الفيروس أكثر من نصف مليون حالة وفاة سنويا، فضلا عن حوالي مليوني حالة من حالات الإسهال الخطيرة.أهداف الدراسة: لتحديد مدى انتشار الاصابة بفيروس العجلي بين المرضى المصابون بالاسهال في مدينة بعقوبة- محافظة ديالى، وكذلك لمعرفة تاثير بعض العوامل ذات العلاقة بنسب الاصابة.المواد وطرق العمل: أجريت هذه الدراسة في مدينة بعقوبة للفترة من الاول من تموز/2007 الى الاول من ايلول/2008 ، جمعت نماذج البراز من 300 مريضا يعانون من الاسهال الحاد، شملت مجموعة المرضى 136 (45,3%) اناثا بمعدل عمر (7,8 ± 4,7) سنة، و 164 ( 54,7%) ذكور وبمعدل عمر (5,3 ± 3,4) سنة، جمعت المعلومات التي تخص المرضى كالعمر، الجنس، السكن، مصدر مياه الشرب، نوعية التغذية ( لمن هم دون السنتين من العمر) من خلال استمارة خاصة اعدت لهذه الدراسة0 استخدم فحص التلازن عالي الحساسية من شركة (Bio-Rad Rota Kit) للكشف عن الفيروس في نماذج البراز، جميع النتائج حللت احصائيا. النتائج: أظهرت النتائج ان نسبة الاصابة الكلية بالفيروس العجلي بين عينة الدراسة كانت 20,3%، وكانت الفئة العمرية دون الخمس سنوات من العمر الاكثر تعرضا للاصابة، سجلت الاصابة بالفيروس العجلي بين البالغين والكبار ايضا، كانت نسبة لاصابة بين الاناث اعلى بشكل غير معنوي مقارنة بالذكور (22,1% مقابل 18,9%)، كانت نسب الاصابة لدى المرضى الذين يستخدمون مياه الانهر للشرب اعلى بشكل معنوي مقارنة باولائك الذين يستخدمون مياه الاسالة او مياة الصهاريج (34,5%، 14,1% و 18,5%) على التوالي، بالرغم من ان الاصابة بالفيروس العجلي قد سجلت على مدار السنة، فان اعلى نسب الاصابة كانت في فصلي الربيع والشتاء ( 22,5% مقابل 21,4%).الاستنتاج: ان الاسهال الشديد بسبب الاصابة بالفيروس العجلي شائع في مدينة بعقوبة، وان الفئة العمرية دون الخمسة سنوات من العمر هي الاكثر تضررا.


Article
Estimation of Interleukin-8 Level in Diarrheic Children Infected with Rotavirus
تقدير مستوى الانترلوكين -8 لدى الأطفال المصابين بالإسهال المصابون بفيروس الروتا

Author: Rukia M. Al-Barzinji
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 1 Pages: 28-34
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objective: Rotavirus is the most important cause of severe diarrhea in children worldwide. We have investigated that certain cytokines especially interleukin- 8 (IL-8) as a chemokine, may play an important role in the pathogenesis of and the protection against rotavirus disease in children. The purpose of this study was to reveal the association between IL-8 and child diarrhea with rotavirus.Methods: Stool samples were collected from 150 children under 5 years of age who developed diarrhea and 45 from non-diarrheic children of equivalent age. All samples were detected for rotavirus and serum IL-8 level. The study was undertaken from May to December of 2006. Enzyme linked immunosorbant assay (ELISA) was applied for detection rotavirus and IL-8.Results: Among the children, female patients with breast feeding were less infected with rotavirus compared to males with artificial and mixed feeding. The IL-8 concentration was highly significantly between the study groups (P< 0.01). Regarding the gender, serum IL-8 level was significantly higher in males than females (P<0.05). However, no significance prevalence in IL-8 level was recorded between gender in healthy control group (P>0.05).Conclusions: Rotavirus infection induces the expression of chemokines as IL-8. These data support the hypothesis that chemokine secretion may play a role in the initiation and modulation of the immune response to rotavirus infection.

Keywords

Rotavirus --- Diarrhea --- Children


Article
SEROLOGICAL DETECTION OF ROTAVIRUS INFECTION IN BOVINE AND HUMAN
الكشف المصلي والجزيئي لاصابات الروتافايروس في الابقار والانسان

Author: Enas R. Mohsin, Khalid H. Al-Jaff
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2016 Volume: 15 Issue: 1 Pages: 349-359
Publisher: Basrah University جامعة البصرة

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Abstract

Rotaviruses, causing acute gastroenteritis, that infect humans and animals around the world. There are many assays had been developed for the detection of rotavirus or the viral antigens. The present study was done on 79 samples of stool collected from pediatric patients with acute watery diarrhea aged from one months to 5 years admitted to Basrah Maternity and children hospital in Basrah province, during the period from October 2014 to February 2015. Ninety diarrheic fecal bovine samples were included in this study. All samples were used for the investigation and detection of rotavirus antigen by Enzyme-Linked Immunosorbent assay (ELISA).According to ELISA results, 10 out of 79(12.7%) pediatric stool samples rotavirus antigens were detected in children. Percentage (20.7%) of positive rotavirus antigen were detected in the patients at second age group (>6 months). Followed by 8% of patients at first age group (<6 months) these differences were not significant (P>0.05). The percentage of rotavirus antigen was higher in males patients (16.7%) compared to females (P>0.05) and also the differences were not significant differences (P>0.05). These results of rotavirus antigen detection in 90 diarrheic bovine fecal samples showed that this antigen was excreted by 56.7%of diarrheic calves. Additionally the higher non-significant (P>0.05) excretion percentage according to age was observed in 63.4 % of calves > 1 year old and the lower percentage(51.1%) was observed in the first age group( < 1year) calves old. The differences in sex were not significant (P>0.05) in the percentage of rotavirus antigen detection were also detected as 63.5% of male fecal samples show positive rotavirus antigen excretion whereas only 47.4% of female fecal samples were positive.


Article
Healthcare providers’ knowledge on rotavirus vaccine at selected primary ‎healthcare centers in Erbil City
معرفة مقدمي الرعاية الصحية بشأن لقاح الفيروسة العجلية في بعض مراكز الرعاية الصحية الأولية المختارة في مدينة أربيل

Author: Kaify Jamil Qadir
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 2 Pages: 1304-1309
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Rotavirus gastroenteritis is the most common cause of acute dehydrating diarrhoea among children younger than five years and globally the most important cause of severe diarrhea in this age group. Most children acquire rotavirus infection before they turn two years of age. Rotavirus vaccination can prevent rotavirus infection. This study aimed to assess healthcare providers' knowledge regarding rotavirus vaccine.Methods: A cross-sectional descriptive study was conducted on 100 healthcare providers at four healthcare centers (Azady, Tayrawa, Mala Fandi and Zhyian), during July to August 2014. Data were collected through the use self-reporting questionnaire format, which was developed for the purpose of the study. A socio-demographic sheet was also constructed to determine characteristics of the subjects. Results: Most of the healthcare providers were in the‎ age group 33-42 years old (31%), 51%, were male, 80% were married, 56% were graduated from the institute, half of them had work experience between 2-11 years and 29% were working in ‎vaccination room. Fifty-four (54%) of healthcare providers had average knowledge while 24 (24%) and 22 (22%) of them had a poor and good knowledge, respectively‎.Conclusion: More than half of healthcare providers had average knowledge regarding rotavirus vaccine


Article
Burden of Rotavirus Gastroenteritis Among Under Five Years Children at Al-Alwaiya Paediatric Hospital

Author: Sinan Ghazi Mehdi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 4 Pages: 318-321
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Rotavirus is the main cause of diarrhea in <5 years children causing high rates of hospitalizations and high mortality.OBJECTIVE:To estimate the burden of rotavirus gastroenteritis among less than five years children attending Al-Alwaiya Pediatric Hospital. To examin the validity of ELISA and Latex screening tests and to find out the concordane rates.METHODS:Across sectional study involved under five years(1-59months) children with acute gastroenteritis attending Al-Alwaiya Pediatric Hospital for the period from 1st of January 2008 to 31st of May 2008. The questionnaire used depended on WHO protocol of the National Rotavirus Gastroenteritis Surveillance Program. LATEX and ELISA tests were used for diagnosis. The period of study included two seasons: Winter and Spring.RESULTS:Stool samples of 342 children with acute gastroenteritis were investigated by general stool examination, stool culture, LATEX and ELISA tests for the presence of any parasite, bacteria and/ or rotavirus antigen respectively. Rotavirus was detected in 162(47.4%) of children with acute gastroenteritis either by LATEX, ELISA or both. Total concordance rate between the two tests was as high as 85.4%. Females were 61(37.7%) and males were 101(62.3%). Age group mostly affected was (>6-12) months which was (31.4%).CONCLUSION:Rotavirus cause 47.4% of acute gastroenteritis cases of the studied sample with no significant statistical difference between rotavirus and other causes of gastroenteritis regarding demographic features (except for gender, more in males), clinical features, and type of treatment and course of disease (except time of onset).Concordance rate between ELISA and Latex was found to be high confirming their validity.


Article
Molecular Identification and Phylogenetic Analysis of Rotavirus in Children Suffered from diarrhea under Five Years Old in Thi-Qar Provience, of Iraq
تشخيص جزيئي و تحليل الشجرة الوراثية لفيروس الدوار المعزول من الاطفال دون سن الخامسة في محافظة ذي قار

Authors: Basim A. Jarullah2 --- Mohammed N. Fenjan
Journal: Journal of Education for Pure Science مجلة التربية للعلوم الصرفة ISSN: 20736592 Year: 2019 Volume: 9 Issue: 1 Pages: 82-91
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

AbstractThe objective of this study is to determine the frequency of the one most important enteric viruses (rotavirus group A) in stool specimens of children aged less than five years, The age ,sex related distribution, seasonal pattern and clinical symptoms. A total of 100 fecal specimens (including 63 males and 37 females) are collected from infants and children under five years of age in Thi-Qar Province south of Iraq during Five Months (From November 2017 To March2018). According to diarrhea suffered children which revealed that 45% are caused by Rotavirus, the frequency of male children patients with diarrhea caused by rotavirus was higher than their female. The samples are categorized into eight groups according to the age of the children: 1-5 months, 6-10 months, 11-15months, 16-20 months, 21-25 months, 26-30 months, 31-35 months and 36-40 months. Age specific frequency in children patients with diarrhea, caused by rotavirus is high in aged 11-15 months. According to results the percentage of infection with rotavirus show that 16 (35.6%) children are fed on Breast feeding, 22 (48.9%) children are fed on bottle feeding and 7 (15.6%) children are fed on mixed feeding. RT-qPCR is performed for detection of Rotavirus based on VP6 gene. Also RT-PCR technique is performed on some positive isolates in RT-qPCR method that used for Rotavirus genotyping by using DNA sequencing analysis. In Rotavirus phylogenetic tree analysis, results are show that the local Rotavirus isolate (IQ-C1) are closed related to NCBI-Blast Rotavirus (JQ069617.1) (EF472951.1).

الخلاصةهذه الدراسة صممت لتحديد واحد من الفيروسات المعوية الأكثر أهميةrotavirus) ) في عينات البراز في الأطفال الذين تقل أعمارهم عن خمس سنوات. وزعت العينات تبعا للعمر,الجنس,الموسم,مكان المعيشة والعلامات السريرية. المجموع الكلي لعينات البراز كان 100عينة(63 ذكور و 37إناث) والتي جمعت من الأطفال والرضع في محافظة ذي قار جنوب العراق خلال 5أشهر من شهر تشرين الثاني 2017إلى آذار 2018. وجد ان نسبة الأطفال الذين يعانون من الإسهال الناتج عن الإصابة ب rotavirus كانت 45% حيث ان الإصابة الأكثر تكرار كانت في الذكور مقارنة مع الإناث. صنفت العينات الى 8 مجموعات تبعا الى اعمار الاطفال من 5-1شهر, من 10-6 شهر 15-11شهر, 20-16شهر,25-21 شهر, 30-26 شهر, 35-31 شهر, 40-36 شهر حيث ان العمر الأكثر عرضة للاصابة بهذا الفايروس كان 11-15 شهر. تبعا للنتائج كانت نسبة الإصابة ب rotavirus بالاعتماد على نوع التغذية ((16 طفل (35.6%) تغذيتهم كانت طبيعية, (22) طفل 48.9%)) كانت تغذيتهم صناعية و(7) أطفال (15.6%) كانت تغذيتهم مختلطة. تم استخدام جهاز RT-qPCR لتحديد الفايروس بالاعتماد على جينات المحفظة للفيروس وأيضا استخدمت تقنية conventional RT.PCR على العينات التي كانت موجبة باستخدام تقنية RT.qPCR لمعرفة التتابع النيوكليوتيدي بطريقة DNA sequencing. اظهرت نتائج تحليل الشجرة الوراثية لل rotavirusللعزلات المحلية علاقة مقربة منNCBl-Blast rotavirus (JQ069617.1)(EF472951.1).


Article
Rotavirus gastroenteritis prevalence among children under five years of age in Karbala City

Author: Adel Ateyah Abd Ali AL-Nasrawi
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2011 Volume: 9 Issue: 2 Pages: 189-196
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Rotavirus is the major agent causing endemic and epidemic diarrhea in young children in both developed and developing countries (1), little is known about prevalence of rotavirus infections in Karbala. Study design and objectives: This cross sectional study was performed to determine the prevalence, clinical significance, and possible risk factors for rotavirus gastroenteritis in Pediatric Teaching Hospital in Karbala governorate during the period from June through October 2oo9. Patients and methods: 386 children less than five years of age with acute gastroenteritis attended Karbala Pediatric Teaching Hospital were studied both hospitalized and out-patients. Rotavirus in stool samples was identified by using two survey tests (One Step Rapid Chromatographic Immune Assay, and Slide Latex Agglutination test). Rotavirus positive patients were divided into two main groups according to the age; the first group was six months and below; and the second group was more than six months of age. Results: generally, rotavirus positive gastroenteritis was more frequent 267(69%) than rotavirus negative gastroenteritis 119(31%) of the total examined stool samples, There was a relative increase in prevalence of rotavirus gastroenteritis in children above six months 142(53%) more than those below six months of age 125(47%) with the clear variance in rotavirus gastroenteritis patients among the gender which referred to an elevation in males 167(63%) more than females 100(37%) in both tested groups, moreover, according to the source of infection there was no difference in children between hospitalized 133(50%) and out-patients 134(50%) in both groups, as well as no clear variance among rotavirus positive patients regarding geographical distribution; urban were 137(51%), and rural were 130(49%) in both groups district to Karbala; in comparison with the type of feeding; the study showed an obvious increase(about two-fold greater risk)in rotavirus gastroenteritis 172(64%) in the children who were not exclusively breast- or bottle fed more than those who were exclusively breast-fed 95(36%) in both diarrheic groups. Conclusions, rotavirus is the main leading cause of severe gastroenteritis among children under five years of age in Karbala particularly in males above six months of age regardless the source of infection and geographic distribution; Rotavirus gastroenteritis can be considered as one of the nosocomial infections in Karbala Pediatric Teaching Hospital; promotion of breast-feeding would augment the impact of providing the effective protection against severe childhood rotavirus diarrhea.

الخلفية العلمية: يعتبر فايروس الروتا من اكبر العوامل المسببة للإسهال المحلي و الوبائي في الأطفال في كل من البلدان النامية والمتطورة . ولا يعرف الكثير عن وبائية الإصابة بفايروس الروتا في الأطفال في مدينة كربلاء. تصميم الدراسة والأهداف: صممت الدراسة الحالية لتحديد نسبة الإصابة والأهمية السريرية وعوامل الخطورة المرافقة للإصابة بالإسهال المعدي المعوي الناتج عن فايروس الروتا في الأطفال وأنجزت الدراسة في مستشفى الأطفال التعليمي في محافظة كربلاء خلال الفترة الممتدة من حزيران إلى تشرين الأول لسنة 2009.المصابين وطرائق العمل: تم دراسة 386طفل دون سن الخامسة من العمر لكل من الراقدين والمراجعين لمستشفى الأطفال التعليمي في كربلاء وتم تشخيص فايروس الروتا في نماذج البراز للأطفال المصابين بالإسهال باستخدام اختبارين مسحيين هما (الاختبار المناعي الكروماتوغرافيا السريع المنفرد و اختبار تلازن حبيبات اللاتكس على الشريحة ), وتم تقسيم الأطفال المصابين بالإسهال الناتج عن فايروس الروتا إلى مجموعتين رئيسيتين حسب العمر: المجموعة الأولى ضمت الأطفال بعمر ستة اشهر فما دون والمجموعة الثانية شملت الأطفال الأكبر من ستة اشهر ولحد الخمس سنوات من العمر. النتائج : أظهرت نتائج الفحص لنماذج البراز للأطفال المصابين بالإسهال إن عدد نماذج البراز الموجبة لفايروس الروتا كان 267(69%) اكبر مما أظهرته نماذج البراز السالبة للفايروس والبالغة111(31%) لجميع نماذج البراز المفحوصة , ولوحظ الارتفاع النسبي في التهاب المعدة والأمعاء الناتج عن فايروس الروتا 142(53%) في الأطفال بعمر اكبر من ستة اشهر أعلى مما عليه في الأطفال بعمر اصغر من ستة اشهر 125(47%) , مع تباين واضح في نسبة الإصابة بالتهاب المعدة والأمعاء الناتج عن فايروس الروتا على مستوى الجنس, والتي بينت ارتفاعا ملحوظا في الذكور 163(63%) اكبر مما لوحظ في الإناث 100(37%) في أطفال المجموعتين, ووفقا لمصدر الإصابة فلم يلاحظ أي تباين في عدد الأطفال المصابين بالتهاب المعدة والأمعاء الناتج عن فايروس الروتا سواء الأطفال الراقدين في المستشفى 133(50%) والمراجعين من خارجها 134(50%) في أطفال المجموعتين, وعلى مستوى التوزيع الجغرافي للأطفال للمصابين بالفايروس في مدينة كربلاء: لم يلاحظ اختلافا واضحا في عدد الأطفال المصابين بالفايروس في المجموعتين, إذ لوحظ إن عدد الأطفال المصابين من مركز المدينة 137(51%) وعدد الأطفال المصابين من أطراف المدينة 130(49%), مقارنة بنوع التغذية للأطفال المصابين بالفايروس- حيث لوحظ ارتفاعا واضحا في نسبة الإصابة وبحوالي الضعفين 172(64%) في الأطفال غير المعتمدين على الرضاعة الطبيعية اكبر مما هي عليه في الأطفال المعتمدين على الرضاعة الطبيعية بصورة مطلقة والتي كانت 95(36%) في أطفال المجموعتين.الاستنتاجات : يعتبر فايروس الروتا السبب الرئيسي لالتهاب المعدة والأمعاء الشديد في الأطفال بعمر دون سن الخمس سنوات في محافظة كربلاء , سيما في الأطفال الذكور بعمر اكبر من ستة اشهر بغض النظر عن مصدر الإصابة بالفايروس (سواء في الأطفال الراقدين داخل المستشفى أو المراجعين من خارجها ) وكذلك التوزيع الجغرافي للمصابين في المدينة, ويعتبر فايروس الروتا كأحد المسببات المرضية التي تنتقل عن طريق المستشفى في كربلاء , وان تحفيز الرضاعة الطبيعية للأطفال يمكن أن يزيد من فرص توفير الحماية الكفوءة ضد الإسهال الطفولي الشديد الناتج عن فايروس الروتا

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