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Article
اشكالية ترسيم الحدود العراقية الكويتية والخروج من احكام الفصل السابع

Authors: ربا صاحب عبد --- قاسم محمد الجنابي
Journal: political issues قضايا سياسية ISSN: 20709250 Year: 2013 Issue: 32 - 33 Pages: 167-190
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Keywords

بحث 5


Article
Serotonin and obesity

Authors: Ali Ismail A. Al-Gareeb --- Ammar W. Ashor
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 99-99
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The central mechanisms which control food intake involve many CNS regions and including different neurotransmitters and neuropeptides. Of these neurotransmitters, is serotonin (5-hydroxytryptamine)


Article
Molecular genetic study of the gene in the serotonin transporte 5-HTT for patients with autism in Iraq
دراسةوراثيةجزيئية للجين الناقل للسيروتونين 5-HTT لمرضى التوحد في العراق

Author: Zubaida Adnan Al-jashammy زبيدةعدنانالجشعمي
Journal: kirkuk university journal for scientific studies مجلة جامعة كركوك - الدراسات العلمية ISSN: 19920849 / 26166801 Year: 2015 Volume: 10 Issue: 1 Pages: 71-77
Publisher: Kirkuk University جامعة كركوك

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Abstract

Autism is a neuropsychiatric disorders , which have been associated with many causes including genetic causes, which affects 4 out of every 10000 people in the world . In this study, the molecular gene serotonin 5-HTT specially 5HTTLPR area multi-format gene to gene serotonin ,which is located on chromosome 17 which revealed it's association with many of the mental disorders as being responsible for the uptake of serotonin by nerve cell after the synapse and signal transduction of nerve to nerve cells. DNA has been isolated from epithelial cells of the lining of the mouth was studied in fifty child diagnosed clinically with autism in Iraq and conducted PCR technique to amplify the genes and migrated to gel Agaros 2% were analyzed style band was done in an attempt to detect any evidence of a link between autism and gene 5-HTT.

التوحدهواحدالاضطرابات العصبيةالنفسيةالذي ارتبطب العديدمن الاسبابومنهاالاسباب الوراثيةويصيب هذاالمرض 4 من بين كل 10 الاف شخص في العالم . وفي هذه الدراسةتم اجراءدراسةجزيئيةلجين السيروتونين5-HTT على الاخص منطقة متعدد الشكل الجيني 5-HTTLPR لجين السيروتونينوالتيتقععلىالكروموسومرقم 17 والذيكشفعنارتباطهبالعديدمنالاضطراباتالنفسيةكونهالمسؤولعنعمليةالتقاطالسيروتونينمنقبلالخليةالعصبيةبعدالمشبكالعصبيونقلالاشارةالعصبيةالىالخلاياالعصبية,حيثتمعزلالـحامضالنوويمنقوصالاوكسجينمنالخلاياالطلائيةالحرشفيةلبطانةالفملخمسينطفلشخصسريرياأصابتهمبالتوحدفيالعراق وبأستخدامتقنية PCR لتضخيمالجيناتوترحيلهاعلىهلامالاكاروز 2٪حيثتمتحليلنمطالفرقةفيمحاولةلكشفأيدليلعلىوجودعلاقةبينالتوحدوجين 5-HTT


Article
PHYSIOLOGICAL AND BIOCHEMICAL CHANGES FOR 5- FLUOROURACIL DRUG (ANTI-CANCER) IN CANCER PATIENTS

Author: Baida R. Ali
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2017 Volume: 16 Issue: 1 Pages: 87-99
Publisher: Basrah University جامعة البصرة

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Abstract

The study was conducted to determine the effect of the 5-Fluorouracil (5-FU) drug is amedication used to treat cancer or the knowledge of 5-FU drug(anticancer) effect might help toattribute these side on physiological and biochemical parameters in human by injection into a vein it isused for colon cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer and cervicalcancer. 80 blood samples were obtained adult human divided into two groups for each group (n = 40),the first group (control) and the second group treatment with drug 5-fluorouracil.There are a significant decrease (P <0.05) in the blood parameters included parameters Redblood cells count, the total number of white blood cells, platelets , hemoglobin and packed cell volumein men treatment with 5-fluorouracildrugcompared with control group. Causing the 5-FU drugsignificant decrease(P<0.05) in Triglycerides, cholesterol levels and total protein in the treatment groupcompared with control group. Also, the result showed a significant increase in Creatinine level ofsecond group in compared with control group, while the results showed non- significant in urea level inhuman treatment when compared with control group.The results showed a significant decrease (P <0.05) in the level of liver enzymes, (ALT AST andALP) in the treatment group with 5-FU when compared with the control group.

Keywords

5-fluorouracil --- parameters --- Cancer.


Article
ORAL IVERMECTIN VS TOPICAL PERMETHRIN 5% CREAM IN THE TREATMENT OF SCABIES: A RANDOMIZED CLINICAL TRIAL
حبوب ايفرمكتين مقابل كريم بيرمثرين 5% لمعالجة الجرب , دراسة سرير عشوائية

Authors: ZEYAD SAMIM AL-DABBAGH زياد صميم الدباغ --- DILDAR FATTAH AL-DOSKY دلدار فتاح الدوسكي
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2015 Volume: 9 Issue: 1 Pages: 83-90
Publisher: University of Dohuk جامعة دهوك

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Abstract

ABSTRACTBackground and Objective: Scabies is a common health problem in Duhok; with a considerable burden on patients, families, communities and the health system. Currently, different types of treatments are available, oral and topical.The study aims to compare the efficacy of oral ivermectin versus topical permethrin 5% cream in treating scabies.Patients and Methods: A randomized control clinical trial was conducted in the dermatology outpatient clinic at Azadi General Teaching hospital in Duhok city, between April 2014 and August 2014. A total of 100 patients clinically diagnosed with scabies were divided randomly into two groups. The first group received topical 5% permethrin cream while the second group received 200 micrograms/kg oral ivermectin. The two groups were followed up for one week and those who did not achieve cure were given a second dose ofeither treatment and their clinical status was evaluated after two weeks.Results: A total of 16 patients were excluded(8 from each group) during the course of the study because they did not show up during the follow up or received another treatment for scabies. The mean age of patients was 29.4 years. Treatment of patients with oral ivermectin resulted in curing 50% of patients, while only 42.9% of patients were cured by using topical permethrin after one week following a single dose of either treatment. The overall cure rate increased after a second dose for uncued cases to 95% with oral ivermectin and 88.1% with topical permethrin; after another two weeks of follow up. However, those differences were statistically not significant.Conclusion: The study concluded that oral ivermectin was as effective as topical permethrin cream in the treatment of scabies.

الخلفية والأهداف: الجَرَب من المشاكل الصحية الشائعة في دهوك ويشكل عبئاً كبي ا رً على المريض وأسرته والمجتمع والنظام الصحي. هناك أنواع مختلفة من العلاج للمرض منها ما يُتناول عن طريق الفم ومنها العلاج الموضعي. تهدف الد ا رسة إلى مقارنة فعالية حبوب آيفرمكتين مع كريم بيرمثرين ٥% في علاج الجرب.طريقة البحث: البحث عبارة عن د ا رسة سريرية عشوائية مع الشاهد أجريت في العيادة الخارجية للأم ا رض الجلدية في مستشفى آ ا زدي التعليمي العام في مدينة دهوك في الفترة بين نيسان ٢٠١٤ وآب ٢٠١٤ . شملت الد ا رسة ( ١٠٠ ) مريضٍ ممن شخصوا سريرياً بداء الجَرَب، تم تقسيمهم إلى مجموعتين عشوائياَ، حيث تم علاج المجموعة الأولى باستخدام كريم بيرمثرين ٥% والمجموعة الثانية باستخدام حبوب آيفرمكتين ٢٠٠ مايكروغ ا رم لكل كغم من كتلة الجسم. تمت متابعة المرضى في المجموعتين بعد الاسبوع الأول من العلاج، وقد اعطيت جرعة ثانية من طريقتي العلاج لمن لم يشفى من المرض و تمت متابعتهم بعد اسبوعين.النتائج: تم استبعاد ١٦ مريضاً من الد ا رسة ( ٨ من كل مجموعة) بسبب تسربهم من المتابعة أو استلامهم لنوع آخر من العلاج أثناء البحث. كان معدل الأعمار للمرضى ( ٢٩.٤ ) سنة. كانت نسبة الشفاء ٥٠ % لمن استخدموا حبوب آيظرمكتين مقارنة ب ٤٢.٩ % فقط لمن استخدموا كريم ثيرمثرين أثناء المتابعة الاولى بعد اسبوع من استخدام جرعة واحدة من الدواء. ارتفعت النسبة الاجمالية إلى ٩٥ % بالنسبة للآيظرمكتين و ٨٨.١ % لثيرمثرين بعد اعطاء جرعة ثانية لمن لم يشفوا أثناء متابعتهم بعد اسبوعين، رغم أن هذا الفرق لم يكن ذا أهمية إحصائية.الاستنتاجات: توصلت الد ا رسة الى أن حبوب آيظرمكتين لها فعالية مماثلة لاستخدام كريم ثيرمثرين الموضعي في علاج الجرب.

Keywords

Scabies --- Ivermectin --- 5% permethrin.


Article
Histopathological Effects of 5-Fluorouracil on the Liver of Male Rabbits ( with and without Folic Acid administration )

Author: Makarem Hameed Ahmad
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2016 Volume: 16 Issue: 28 Pages: 59-66
Publisher: Mosul University جامعة الموصل

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Abstract

Aims : The objective of this study is to evaluate the effects of 5-fluorouracil (5-FU) on the liver tissue of rabbits, as well as the effect of folic acid on the effectiveness of 5-FU on the rabbit's liver. Materials and Methods: In this study nine adult male rabbits ,aged about 3 months were used and divided into three main groups .Group 1 : served as a control group and received normal saline only.Group 2 : treated by 5fluorouracil , 10 mg / kg intraperitonealy twice weekly for 8 weeks. Group 3 : treated by 5-fluorouracil , 10 mg / kg intraperitonealy twice weekly for 8 weeks with 5mg of folic acid orally twice weekly for 8 weeks .The animals were sacrificed and livers were excised and processed for histological study. Results: The liver of the treated group 2 shows disturbance in the architecture of hepatic lobule , swelling and vacuolation of the hepatocytes ,with ballooning degeneration and areas of necrosis. Congestion in the portal blood vessels and congestion in the central vein , together with congestion and dilatation of the sinusoids. Infiltration of mononuclear inflammatory cells in the portal area and around the central vein .While liver sections of group 3 show slight disturbance in hepatic cords architecture , hepatocytes showed no swelling and few vacuolation in their cytoplasm ,mononuclear cells infilitration mainly in the portal area and in lesser degree than that found in group 2 ,necrosis were not present. Conclusion:Toxic effect of 5-FU was observed on the liver tissue of rabbits , and an effective drugs must be applied with anticancer agents to improve liver function .

Keywords

5-fluorouracil --- liver --- rabbit


Article
Association between Interleukin-5 & Body Mass Index among Iraqi Asthmatic Patients

Authors: Wala'a E. Jasim --- Batool A. Al-Haidary --- Yacoob Y. Al-Rubayei
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 116-120
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Asthma is an allergic hypersensitivity disease in which many mediators play a role in its pathogenecity. One of these etiological agents is the mediators such as Interleukin-5 (IL-5). The aim of this study to demonstrate the association between IL-5 and obesity in asthma development. Materials & Methods: One hundred and four sera samples for asthma cases have been studied in comparison with 41 non-asthmatic bronchitis as a patient controls beside 30 apparently healthy controls. Cytokine has been estimated using ELISA method in correlation with Body Mass Index (BMI). Results: This study revealed a significant correlation between IL-5 concentration and BMI (P<0.05), particularly among females. Conclusion: There is certain correlation between obesity and asthma accompanied by IL-5. Key

Keywords

Asthma --- IL-5 --- ELISA --- BMI.


Article
Synthesis of 5-Fluorouracil Derivatives as Possible Mutual Prodrugs with Meloxicam and Ibuprofen for Targeting Cancer Tissues

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Abstract

In the present study, five derivatives have been designed to be synthesized as possible mutual prodrugs for 5-Fluorouracil (5-FU) and non steroidal anti-inflammatory drugs (NSAIDs) to selectively deliver the drugs into the cancer cells. The synthesis of the target compounds were accomplished following multistep reaction procedures, the chemical reaction followed up and the purity of the products were checked by TLC. The structure of the final compounds and their intermediates were confirmed by their melting points, infrared spectroscopy and elemental microanalysis, the hydrolysis of compound III was studied using HPLC technique. According to the results mentioned above, compounds (I&#8722;V) can be good candidates as possible mutual prodrugs of 5-FU and NSAIDs that can selectively deliver the parent drugs into the cancer cells by the effect of enzymes that elevated in tumor tissues compared with normal tissues.

تم في ھذه الدراسة تصمیم خمسة مشتقات لتخلیقھا كمقدمات دوائیة ثنائیة محتملة لل ( 5- فلورویوراسیل) والادویة المضادةللالتھابات غیرالستیرویدیة لایصال الادویة وتحریرھا بأنتقائیة في الخلایا السرطانیة. تم تحضیر ھذه المركبات باتباع طریقة التفاعلمتعدد الخطوات، وتم مراقبة جمیع التفاعلات والتأكد من نقاوة المركبات بواسطة كروماتوغرافیا الطبقة الرقیقة، كما تم متابعةالمركبات الوسطیة والمركبات النھائیة والتأكد من تحضیرھا من خلال قیاس درجات الانصھار والتحلیل الطیفي للاشعة تحت الحمراء،بأستخدام تقنیة الاستشراب السائل عالي الاداء وفقآ للنتائج المبینة اعلاه، (III) والتحلیل الدقیق للعناصر. وقد تم دراسة تحلل المركبمرشحات كمقدمات دوائیة ثنائیة محتملة لل ( 5- فلورویوراسیل) والادویة المضادة للالتھابات (I−V) یتضح بأن المركباتغیرالستیرویدیة لھا القدرة على ایصال الادویة بأنتقائیة للخلایا السرطانیة وبألیة تحریر تتضمن تأثیر الانزیمات الموجودة بمستوىاعلى في الانسجة السرطانیة مقارنة مع الانسجة الطبیعیة.

Keywords

Anticancer --- 5-Fluorouracil --- NSAIDs --- prodrug.


Article
Activity and Properties of 5- Nucleotidase in Human Amniotic Fluid
فعالية وخواص أنزيم 5 - نيوكليوتايديز في السائل الأمنيوني البشري

Authors: Raja A. AL-Taii رجاء مصطفى حسين العناز --- Muna H. Jankeer منى حسين جانكير
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2009 Volume: 20 Issue: 3A Pages: 25-34
Publisher: Mosul University جامعة الموصل

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Abstract

The present research includes a study of activity and properties of 5 - Nucleotidase (5-NT, EC.3.1.3.5) was determined in human amniotic fluid using coloremetric method. Maximal activity of the enzyme was obtained in a reaction mixture containing 40 mM of Barbiturate-HCl buffer at pH 7.5 containing 11 mM of adenosine 5- monophosphate (5-AMP) as a substrate and 50 l of amniotic fluid (Enzyme volume). The reaction mixture was incubated at 37C for 30min, under the optimum condition. The enzyme activity equal to (66.7±0.32) unit per liter in amniotic fluid.

تضمن البحث الحالي دراسة فعالية وخواص أنزيم 5 - نيوكليوتايديز (5- Nucleotidase, EC.3.1.3.5) في السائل الأمنيوني البشري باستخدام الطريقة اللونية، إذ أعطى الأنزيم أفضل فعالية في خليط التفاعل المكون من 40 ملي مولار من المحلول المنظم الباربوجريت- HCl، بدالة حامضية 7.5 والحاوي على 11 ملي مولار أدينوسين 5 - أحادي الفوسفيت (5-AMP) كمادة أساس وحجم من السائل الأمنيوني (حجم الأنزيم) مساويا لـ 50 مايكروليتر، حضن خليط التفاعل بدرجة حرارة 37  م لمدة 30 دقيقة. تحت هذه الظروف المثالية ، تبين أن الفعالية الأنزيمية مساوية لـ (0.32 ± 66.7) وحدة لكل لتر من السائل الأمنيوني.


Article
IL-5 As Indicator of Acute Toxoplasmosis

Authors: Suha A.AL-Fakhar --- Sami Y. Guirges
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 1 Pages: 134-138
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Exposure to Toxoplasma gondii may result in either chronic infection or acute infection, the latter being asymptomatic or symptomatic. Toxoplasma infection stimulates humoral immune response ,in addition to cellular mediated immunity. Also cytokines have a role in resistance to T.gondii like IL-5 which has protective role during infection with the parasite.OBJECTIVE:This study aimed to assess the correlation between IgM and IgG Toxoplasma antibodies and IL-5 in the course of acute toxoplasmosis .PATIENTS AND METHODS :45women suspected of having toxoplasmosis were tested by ELISA IgM and IgG toxoplasma antibodies , and the level of serum IL-5 was tested using ELISA technique only on 32 women .RESULTS:The results showed that there are higher titer of IgM and IgG-Toxoplasma antibodies and higher levels of serum IL-5 in women with Toxoplasma infection .CONCLUSION:Serum IL-5 can be used as indicator to predict the presence of acute toxoplasmosis in pregnant women at high risk to toxoplasmosis.

Keywords

toxoplasmosis --- IgG --- IgM --- IL-5.

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