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Article
Determination of Interleukin-8 (IL-8) Levels In Pneumonia Patients
تحديد مستوى الانترليوكين 8-في المرضى المصابين بذات الرئه

Authors: Karam R. Aljarah كرم رياض الجراح --- Rasmyia A.Abu-risha رسمية عبد ابو ريشة --- Adeeb Aljader اديب الجادر
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 1A Pages: 89-94
Publisher: Baghdad University جامعة بغداد

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Abstract

The result of interleukin-8 level through acute and chronic phases in pneumonia patients sera was showed high level in patients compared with healthy persons (0.194 ± 0.046, 0.095 ± 0.006 pg / ml , respectively) with a significant difference statistically (P˂0.05). The results of interleukin 8 levels in the age group ( 2 months -3 years ) higher than the age groups ( age 15-60years ) (age 60-85years ) (0.154 ± 0.04, 0.131 ± 0.02, 0.113 ± 0.2 pg / ml , respectively) with no significant difference (P˂0.05).

ظهرت نتائج قياس الانترليوكين 8 خلال الطورين الحاد والمزمن في مصل مرضى ذات الرئه كانت باعلى المستويات مقارنه بالاصحاء (0.194 ± 0.046 , 0.095± 0.006 بيكو غرام /مل على التوالي) مع فرق معنوي احصائيا (P˂0.05).كذلك في الفئه العمريه (شهرين-3سنوات ) اظهرت نتائج قياس انترليوكين 8 اعلى المستويات مقارنه مع بقيه الاعمار (15-60 سنه) (60-85 سنه) (0.154± 0.04, 0.131± 0.02, 0.113±0.2 بيكو غرام /مل على التوالي )مع بفرق غير معنوي .P˂0.05


Article
The Role of Interleukin-8 in Patients with Primary Fibromyalgia

Authors: Enas J. Kadim --- Munaf S. Daoud --- Mohammed H. Alosami
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 347-351
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Fibromyalgia syndrome (FMS) is a common rheumatologic syndrome with multiple manifestations and associated with many diseases, it characterized by chronic wide spread muscular pain and tenderness. Further, circulatory levels of pro-inflammatory cytokines like IL-8 and others may be altered in FMS patients, possibly associated with their symptoms.The objective of the study is to measure IL-8 concentration and to evaluate its role in the pathogenesis of primary FMS.OBJECTIVE:Fifty patients with primary FMS were included in the study (37 females and 13 males) the age range of (17-65) years (Mean ± SD) (40.13 ± 12.0) years, and thirty healthy individuals volunteers (21 females and 9 males), whose age and sex matching with FMS patients, age ranging (18 - 63) years, (Mean ± SD) (36.1 ±10.0) years.METHODS:IL-8 concentration was measured in sera of patients and controls by ELISA kit. Anthropometric measurements like body mass index (BMI) and waist circumference (WCr) were taken ,besides other features like sleep disturbance , emotional distress , and fatigue were reported.RESULTS:IL-8 concentration was higher in FMS patients than controls(40.24±22.0) pg/ml vs. (19.16±7.8) pg/ml. This elevation was highly significant statistically (p=0.000).Other measurements in patients group like BMI, WCr were(28.39±5.0) Kg/m2 and (100.34±13.21) cm respectively .These values were highly significant when compared to their control group (p=0.002)and (p=0.008) respectively .Clinical features like sleep disturbance, emotional distress ,and fatigue showed highly significant difference between the two groups . No significant differences were reported with respect to age and sex.CONCLUSION:The result of the current study suggest that interleukin-8, (IL-8) might have a role in the pathogenesis of FMS.


Article
IL-1α and IL-8Levels During Gram-Negative and Gram-positive Bacteremia in Leukopenia Leukemic Patients.

Author: Sevan N. A. Abdallah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 4 Pages: 332-338
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:A quantitative relationships between circulating leukocytes and infection was established in patients with leukemia, in particular, the probability of being infected is proportional to the severity and duration of leukopenia (1). Infection with gram- negative as well as gram-positive microorganisms may lead to septic shock and death (2, 3) . The major functional activities of cytokines are concerned with the regulation of the development and behavior of the immune effector cells. IL-1 is one of proximal cytokines. IL-1 act to stimulate the release of distal cytokines, such as IL-6 and IL-8, IL-8 is most closely related to the severity of the physiological response to infection and systemic inflammation.OBJECTIVE:This study was conducted to detect the levels of IL-1 and IL-8 during Gram negative and Gram positive bacteremia. That could be useful in determining an appropriate choice for antimicrobial drug depending on the antimicrobial susceptibility pattern.METHODS:IL-1α and IL-8 was studied in (28) adult leukopenic patient with bacteremia, males and females, more than 15 years old. The study was including (20) healthy control. The bacteremic cases were obtained by culturing blood samples aerobically and anaerobically.The isolates were identified on the basis of their morphological, cultural and biochemical characteristics. Interleukin-1α and interleukin-8 cocentration were measured by using a commercially available enzyme-linked immunosorbent assay (ELISA).RESULTS:Statistical analysis show no significant difference in IL-1α levels between Gram-negative and Gram-positive bacteremia in leukopenic leukemia patients (P=0.803). While statistical analysis show significant difference between patient with Gram-negative and Gram-positive bacteremia in leukopenic leukemia patients (P=0.037).CONCLUSION:In leukopenic leukemia patients with bacteremia we may could determining an appropriate choice for treatment depending on IL-8 levels in the circulation of those patients and the antimicrobial susceptibility pattern.


Article
The association between a marker of oxidative stress in Saliva and severity of periodontal disease

Author: Dr. Lekaa M. Ibrahem B.D.S, M. Sc.* د. لقاء ابراهيم
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2007 Volume: 4 Issue: 1 Pages: 56-66
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The aim of this study is to determine the relationship between the level of 8-hydroxydeoxyguanosine (8-OHdG) in saliva and severity of periodontal diseaseMaterial and method: Twenty five periodontitis patients were divided into two subgroups according to severity of periodontal disease (fifteen patients with probing pocket depth (PPD) <6mm and ten patients with PPD>6mm). Clinical examination which included measurement of both PPD and bleeding on probing (BOP) were carried out before and after initial periodontal treatment in addition to assessment of 8-OHdG in saliva and gingival crevicular fluid (GCF).Result: Salivary level of 8-OHdG in those with PPD >6mm was higher than those with PPD<6mm. Also this study evaluated 8-OHdG levels in GCF, it was detected only in periodontitis patients with PPD>6mm (mean PPD = 7.34) and only in some cases (4 out of 10).Conclusion: These data suggest that periodontally-involved teeth with deep pockets are a major source of salivary 8-OHdG levels may prove to be useful identifying patients with teeth of hopeless prognosis.


Article
The Role of Interleukin-8 in Restenosis after Coronary Stent Implantation
دور انترلوكين-8 في عودة التضييق بعد زرع شبكة الشرايين التاجية

Authors: Reem S. Saeed د. ريم سالم سعيد --- Khalida Al-Mousawy د. خالدة الموسوي --- Haithum I. Baqir د. هيثم باقر --- Hilal Al-Saffar د. هلال الصفار
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 3 Pages: 248-252
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Background: In-stent restenosis (ISR) is a serious complication of percutaneous coronary intervention (PCI) with stent implantation. Variable factors may interact in the process of ISR. Immuno-inflammatory activity mediated by different cytokines could have a role in the ISR. Among these could be the chemokine, interleukin-(IL-8).Aim of the Study: To assess the role of serum level of interleukin-8 in the process of ISR.Patients & Methods: Forty patients with ISR (diagnosed by coronary angiography) within six months after coronary stenting. Patient control group enrolled 30 subjects who had had coronary stenting with no evidence (by angiography) of ISR .The third group composed of 20 healthy controls.Results &Conclusion: Patients with ISR were mainly above the age of 50 years (62.5%) with male predominance (70%).Interleukin-8 was below detectable level (cut off value=553 pg/ml) in almost all cases with ISR with only 10% of the cases with ISR occur in the outer line values (outside usual range). There was no significant difference in the frequency of detectable IL-8 levels between ISR patients and patient control group (P=0.284), neither between ISR patients and healthy controls (P=0.143). In conclusion, the link between IL-8 and ISR was not found in this study. Key words: Interleukin-8, Restenosis, Coronary stents.

الملخص: استخدم اختبار مترابطة الخميرة بمادة ماصة المناعة/ الطريقة المباشرة للتحري عن نسبة المحرك المناعي للخلايا انترلوكين رقم( 8 ) ل 90 عينة د م تعود إلى 40 مريضا يعانون من عودة التضييق في شبكة الشرايين التاجية بعد بضعة شهور من زرعها, 30 مريضا تمت عملية زرع الشبكة لهم بدون مضاعفات عودة التضييق فيها( المجموعة الضابطة الأولى) و20 حالة من الأصحاء المتطوعين ( المجموعة الضابطة الثانية). أظهرت الدراسة أن نسبة المحرك المناعي رقم 8 في 90% من المرضى المصابين بعودة التضييق بعد زرع الشبكة كانت اقل من المستوى المنظور(أقل من 553 بيكوغرام / مل) وكذلك عدم وجود فرقا ذو دلالة إحصائية واضحة بين مجموعة المرضى المصابين بالتضييق داخل الشبكة والمجموعة الضابطة الاولى (قيمة الاحتمالية =0,284 ) أو مع مجموعة الأصحاء (قيمة الاحتمالية=0,143). لم تثبت الدراسة دورا مهما ل انترلوكين ـ8 في تنشيط التفاعل المناعي في منطقة عودة التضييق.


Article
Spectroscopic and Thermodynamic Studies of charge Transfer Complexes for 7,7,8,8-tetracyanoquinodimethane(TCNQ) and Some Organic Telluride compounds
دراسه طيفيه وثرموديناميكيه لمعقدات انتقال الشحنه بين رباعي سيانو-كوينوثنائي ميثان(TCNQ) وبعض التلوريدات العضويه

Author: Layla Jasim Abbas ليلى جاسم عباس
Journal: Journal of Basrah Researches (Sciences) مجلة ابحاث البصرة ( العلميات) ISSN: 18172695 Year: 2014 Volume: 40 Issue: 2A Pages: 58-67
Publisher: Basrah University جامعة البصرة

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Abstract

The Charge Transfer complexes(CTC) between 7,7,8,8-tetracyanoquinodimethane (TCNQ) and some tellurium compounds have been investigated spectrophotometrically in the UV-Visible region. The values of energies of transition , ionization potential (IP),and the dissociation energies of charge transfer (CT). complexes excited state(w) of these complexes have been calculated and were in the range of 9.96 - 9.35 ev.The charge transfer parameters of the tellurium compounds as a donor with TCNQ as accepter which is represented by ECT. ,KCT. ,Δ G وΔ H, and Δ S ,have been estimated .The data was analyzed using Bensi- Hildebrand equation ,from which the formation of 1:1 charge transfer complex was concluded.

درس تكوين معقدات نقل الشحنة بين رباعي سيانو-كوينوثنائي ميثان وبعض التلوريدات العضوية طيفيا في المنطقة الفوق بنفسجيه- المرئيه وحسبت قيم طاقه الانتقال وجهد التأين وثابت التفكك وطاقه الاثاره لتلك المعقدات وكانت تتراوح بين (9.96 - 9.35) .كذلك قدرت قيم معاملات نقل الشحنه والمتمثله ب لمركبات التلريوم كواهب مع ECT. , KCT , Δ G, Δ H, Δ S كمستقبل بنسبه 1:1 TCNQوحللت ا لبيانات باستخدام معادله بنسي –هلدبراند


Article
The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients

Authors: Khalida M .Al-Moussawy --- Nahla Ghanim --- Wifaq M. AL-Wattar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2007 Volume: 49 Issue: 1 Pages: 111-115
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Tinea versicolor is a common dermatological problem ,world wide distribution ,caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal .Many factors play a role in the etiology of TV among these could be the disturbed immune systemwhich may be related to the ability of TV alter the immune system by a process calledImmunomodulation leading to subsequent infection.Immuno-inflammatory activity mediated by different cytokines could have a role in the etiologyof TV.Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients withTV as compared to immunocompramized patients and healthy groups.Patients and methods: This study enrolled 50 total patients, 15 of them were as patients controlgroup who were immunocompramized with evident skin lesion ,to be compared serologically with 15patients who had TV and normal immunity, the control group composed of20 healthy volunteers.Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera ofall groups.Results and discussion: The statistical differences in the rate of detectable IL-4 level between TVand healthy control p< 0.001,while the difference was a highly significant between the healthycontrol and immunocompramized patients with TV,P<0.00338.The difference between twodiseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant.IL-8 the results of our study showed a significant difference between the healthy control and thepatients with tinea versicolor, p-value was( 0.05).In this study there was a nice findings by which the difference between the healthy control and theimmunocompramized patients was highly significant as ,p<0.005.Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it actsas an adjuvant, activates the complement cascade, and elicits both cellular and humoral immuneresponses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast,it also seems to have the ability not only to evade the immune system but actually to suppress theresponse directed against


Article
Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations UsingDiazotization Reaction
التقدير الطيفي للهيدروكلوريد ميتوكلوبراميد في بعض المستحضرات الصيدلانية باستخدام تفاعل الاقتران الازوتي

Authors: Kasim M. Al-Abbasi قاسم محمد حسين العباسي --- Salim A. Mohammed سالم علي محمد --- Lamya A. Sarsam لمياء عدنان سرسم
Journal: Rafidain journal of science مجلة علوم الرافدين ISSN: 16089391 Year: 2011 Volume: 22 Issue: 3E Pages: 76-88
Publisher: Mosul University جامعة الموصل

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Abstract

A simple, rapid and sensitive spectrophotometric method has been developed for the quantitative determination of metoclopramide hydrochloride in both pure form and in its pharmaceutical formulations. The method is based on diazotization of primary amine group of metoclopramide hydrochloride with sodium nitrite and nitric acid followed by coupling with 8-hydroxyquinoline in alkaline medium to form a pinkish – red coloured species, which showed a maximum absorption at 528 nm against reagent blank. Beer's law was obeyed over the concentration range of 5-300 μg / 25 ml. with a molar absorptivity 3.1×104 l.mol-1.cm-1. The method is suitable for the determination of metoclopramide hydrochloride in the presence of other ingredients that are usually present in dosage forms and the recoveries were obtained in the range of 98.9-100.0%. The method does not resort to temperature control or to solvent extraction. The effect of organic solvent on the spectrophotometric properties of the azo dye, the composition and stability constant have been worked out. The method has been successfully applied to the determination of metoclopramide in its pharmaceutical preparations ( tablet, syrup and drop ) .

تم اقتراح طريقة طيفية بسيطة وسريعة وحساسة لتقدير هيدروكلوريد الميتوكلوبراميد في بعض المستحضرات الصيدلانية تعتمد الطريقة على ازوتة مركب الميتوكلوبراميد بواسطة نتريت الصوديوم وحامض النتريك ثم اقتران الميتوكلوبراميد المؤزوت مع الكاشف 8-هيدروكسي كوينولين في وسط قاعدي لتكوين صبغة آزوية ملونة، كانت الصبغة المستقرة والذائبة في الماء قد أعطت أعلى امتصاص عند الطول ألموجي 528 نانوميتر. وان حدود قانون بير ضمن مدى التركيز 300 -5مايكروغرام من الميتوكلوبراميد في حجم نهائي 25 مل وكانت قيمة معامل الامتصاص المولاري 3.1×104 لتر.مول-1.سم-1. الطريقة المقترحة لا تحتاج إلى السيطرة على درجات الحرارة أو الاستخلاص بالمذيب. لقد تمت دراسة تأثير عدد من المذيبات العضوية وتركيب الصبغة وثابت الاستقرارية والمتداخلات، وطبقت الطريقة بنجاح لتقدير الميتوكلوبراميد في نماذج مختلفة من المستحضرات الدوائية الحبوب والشراب والقطرات.


Article
Corrosion Inhibition of Aluminum Alloy 5083

Authors: Huda A. Dahyool --- Aprael S. Yaro ابرائيل سركيس يارو
Journal: Iraqi Journal of Chemical and Petroleum Engineering المجلة العراقية للهندسة الكيمياوية وهندسة النفط ISSN: 19974884/E26180707 Year: 2009 Volume: 10 Issue: 4 Pages: 19-25
Publisher: Baghdad University جامعة بغداد

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Abstract

The corrosion inhibition of aluminum alloy .5083 by an environment friendly compound called (8- Hydroxyquinoline) in acidic and alkaline solutions ofpH (2 and 12) respectively were studied using weight loss and polariza techniques. Also to examine the main and combined effects of the inhibitor concentration, pH. and contact time using factorial experimental design. Results show that corrosion rate decreased with increasing both inhibitor concentration and contact time and increased with increasing pH value. The polarization curves show that 8-hydroxyquinoline is a cathodic inhibitor


Article
Level of Interleukin–8 in the Sera of Asthmatic Patients in Baghdad

Author: Hind J. Hassoon
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2010 Volume: 9 Issue: 1 Pages: 40-42
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Asthma is a common, chronic inflammatory, anaphylactic hypersensitivity disease .It is a world-wide distributed with a range extends from mild to severe fatal episodes. Fifty eight asthmatic patients sera have been collected from Al-Zahra'a consultant for asthma and allergy , during the period between July / 2008 – September / 2008 and thirty two sample of healthy peoples as a control group .The patients age ranged from ( 12-45 ) years .Enzyme linked immunosorbent assay ( ELISA) has been applied estimation of interleukin – 8(IL-8).The results showed that highly significant differences (P < 0.0001) between asthmatic patients – positive IL–8 and asthmatic patients – negative IL-8. There are no significant differences between residency (urban and rural regions) and levels of IL-8. There is a good relation between body mass index (BMI) and asthmatic patients (P < 0.005), but no relation between body mass index and levels of IL-8.

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