research centers


Search results: Found 81

Listing 1 - 10 of 81 << page
of 9
>>
Sort by

Article
Immunohistochemical Expression of Matrix Metalloproteinase-9 in Jaws and Long Bones Osteosarcomas

Authors: Bashar Hamid Abdullah --- Luay Edward Alkhuri --- Khitam Razzak Alkhafaji --- Salam Nihad Jawad**
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 3 Pages: 403-407
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:Matrixmetalloproteinases (MMPs) are a class of matrix basement membrane degrading enzymes which were shown to be associated with metastases in several human tumors.OBJECTIVE:This study is aimed to investigate the potential effect of MMP-9 in imparting the frequently reported different behavioral pattern between jaws and long bones osteosarcomas.METHODS:Tissue blocks of ten cases of jaws osteosarcomas and another ten of long bones osteosarcomas were collected and stained immunohistochemically with monoclonal antibodies to MMP-9.RESULTS:The majority of cases (70%) were positive for MMP-9 expression which indicates a role in tumor spread, however; there was no significant difference between the sites.CONCLUSION:The study indicates that MMP-9 is probably not involved in the biologic differences between jaws and long bones osteosarcomas


Article
Propose a mathematical formula to verify the authenticity of any product of the integers using a scale (9) and verified using computer
اقتراح صيغة رياضية للتحقق من صحة حاصل ضرب أى عددين صحيحين باستخدام مقياس (9) والتحقق من ذلك باستخدام الحاسب الآلي

Author: Abd A. Hamed عبد علي حمد
Journal: AL-Anbar University journal of Economic and Administration Sciences مجلة جامعة الانبار للعلوم الاقتصادية والادارية ISSN: 19988141 Year: 2012 Volume: 4 Issue: 8 Pages: 394-406
Publisher: University of Anbar جامعة الانبار

Loading...
Loading...
Abstract

This research aims to propose a mathematical formula to verify the authenticity of the product of any two numbers are correct, using a scale (9) and verify it using the computer. The research has been divided into two sections , the first section involved the theory part to derive mathematical formula and the other section was the applied part to the formula by taking some mathematical examples to ensure the validity of the proposed formula and using the program for this formula.

يهدف هذا البحث الى اقتراح صيغة رياضية للتحقق من صحة حاصل ضرب اي عددين صحيحين باستخدام مقياس (9) والتحقق من ذلك باستخدام الحاسب الآلي حيث تم تقسيم البحث الى قسمين تضمن القسم الاول الجانب النظري لاشتقاق الصيغة الرياضية المقترحة أما القسم الثاني فقد تضمن الجانب التطبيقي لهذه ألصيغه من خلال اخذ بعض الأمثلة الرياضية والتأكد من صحة الصيغة المقترحة وباستخدام البرنامج الحاسوبي المعد لهذه الصيغة.


Article
Prevalence of matrix metalloproteinase (MMP-9) in urinary bladder cancer
انتشار MMP-9) - Matrix metalloproteinases - 9 ) في سرطان المثانة البولية

Loading...
Loading...
Abstract

Background: Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases are involved in tumor invasion, metastasis as well as in the early stages of carcinogenesis,the aim of this study was to explore whether changes in matrix metalloproteinase-9 (MMP-9) are involved in the urinary bladder cancer.Methods: Expression of MMP-9 was evaluated in the tumor of 30 urinary bladder cancer cases and 20 control group with in situ hybridization.Results: Increased expression of MMP-9 was significantly higher in tumor compared with normal samples. Expression of MMP-9 did not found any significant association with tumor age, sex, grade and muscle invasion.Conclusion: This study shows that MMP-9 may play an essential role in the determination of bladder cancer.

Matrix metalloproteinases هي عائلة من الانزيمات الخارج خلوية المحطمة للبروتينات التي تشارك فيغزو الورم، وكذلك ورم خبيث في المراحل المبكرة من السرطانوالهدف من هذه الدراسة:هو استكشاف ما إذا كان MMP-9 يشارك في تطور سرطان المثانة البولية.المواد وطرق العمل: تم تقييم التعبير عن MMP-9 في ورم 30 حالات سرطان المثانة البولية و20 مجموعة سيطرةبطريقة التهجين في الموقع: الأساليب.النتائج: كان التعبير زيادة MMP-9 أعلى بكثير في الورم مقارنة مع العينات الطبيعية. لم يتم العثور على أي ارتباط معنويبينMMP-9 مع تقدم العمر والجنس والدرجة وغزو العضلاتالاستنتاج: هذه الدراسة تبين أن تعبيرMMP-9 يلعب دور مهم في سرطان المثانة .


Article
Detection of Carbohydrate Antigen CA19-9 Levels in Sera and Tissues' Homogenate of Breast and Thyroid Benign Cases

Authors: Abdulrahman R. Mahmood --- Zeyan A. Ali --- Gheid H. Alubaidi
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 1 Pages: 62-64
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

The aims of the present study are to evaluate the levels of CA19-9 in sera and tissues' homogenate of breast and thyroid benign patients in order to assess its use as an early diagnostic parameter in differentiation between malignant and benign cases. The study was conducted on 8 patients with breast benign tumor and 8 patients with thyroid benign tumor, by the enzyme linked immunosorbent assay (ELISA) technique. The results of CA19-9 levels in sera were (15 ±1.58 and 10.67 ±2.08)U/ml respectively compared with serum CA19-9 levels of control group which was 7.74 ±4.92 U/ml, the results were found to be highly significantly in breast tumor patients and non significantly in thyroid tumor patients than control group. The results of CA19-9 levels in tissues' homogenate were (356.2 ±173.75 and 20 ±14.4)U/ml respectively. The results were found to be highly significant in tissues' homogenate of breast tumor patients and non significant in thyroid tumor patients of higher compare with the it's serum levels of the same patients groups.

الغرض من الدراسة الحالية هو قياس مستويات CA19-9 في مصول وأنسجة مرضى أورام الثدي والغدة الدرقية الحميدة لغرض تحديد امكانية استخدامه كمؤشر تشخيصي مبكر يمكن من خلاله التمييز بين الحالات الحميدة والخبيثة. اجريت الدراسة على 8 مرضى مصابين باورام الثدي الحميدة و8 مصابين باورام الغدة الدرقية الحميدة بواسطة تقنية الامتزاز المناعي الانزيمي (ELISA). وقد كانت النتائج لمستويات CA19-9 في المصول (15±1.58 و 10.67±2.08)U/ml مقارنة مع مستوياته في مجموعة السيطرة والتي كانت(7.74±4.92)U/ml, و أظهرت النتائج قيمة معنوية عالية جدا في مصول اورام الثدي وقيمة معنوية غير عالية في اورام الغدة الدرقية مقارنة بمجموعة الاصحاء. اما بالنسبة لمجانس انسجة المرضى فقد كانت مستوياته (356.2±173.75 و 20±14.4)U/ml بالتعاقب. أظهرت النتائج قيمة معنوية عالية جدا في مجانس انسجة اورام الثدي وقيمة معنوية غير عالية في اورام الغدة الدرقية مقارنة مع مصول نفس المرضى.


Article
Matrix Metalloproteinase – 9 Expressions Associated With Malignant Colorectal Carcinoma
تعبير Matrix Metalloproteinase – 9 المقترنه بسرطان القولون المستقيمي

Author: Zainab Fadhel Ashoor زينب فاضل عاشور
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 2 Pages: 74-78
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Cancer metastatic is dependent on capability of tumor cells to enter "blood and lymphatic system" and there after form tumors in "lymph nodes and distant organs". Matrix metalloproteinase-9(MMP-9) is considered to as important for degradation of the basement membrane and extracellular matrix through cancer invasion and other tissue-remodelling events. This study evaluate the value of Matrix metalloproteinase-9, by Immunohistochemical technique in a series of50 colorectal carcinoma tissues. There was a significant difference betweenMMP-9protein and tumor differentiation, as well as tumor stage.There was highly significant difference in mean percentage of (MMP-9) proteins expression in tissue of colorectal carcinoma (CRC) and colorectal normal tissue (CRN).Conclusion: This study shows that (MMP-9)expression in colorectal cancer is related with better prognosis.

يعتمد انتشارالسرطان على قدرة الخلايا الخبيثة لدخول الدم والجهاز اللمفاوي وبالتالي تشكيل أورام في الغدد الليمفاوية والأعضاء البعيدة. وتعتبر مصفوفة الفلزي-9 (MMP-9) بأنها مهمة لتدهور الغشاء القاعدي والمواد خارج الخلية خلال غزو السرطان وغيرها من احداث إعادة تشكيل الأنسجة.في هذه الدراسة تم تحديدقيمةMMP-9بواسطة تقنية التحليل المناعى الكيميائيفي سلسلة من50نسيج من سرطانالقولون المستقيمي هناكفرق معنوي بين بروتينMMP-9وتمايز الورم ،فضلا عن مرحلةالورم.كما ان هناكاختلاف معنوي كبيرفينسبةمتوسطتعبير بروتينMMP-9فيأنسجةسرطانالقولون المستقيميوالأنسجة الطبيعية القولون والمستقيم. تبين هذه الدراسه ان تعبير MMP-9 في سرطانالقولون المستقيمي ترتبط مع تقدم الورم.


Article
The Role Of Tumor Markers In The Diagnosis And Follow UpIn Patients With Pancreatic Cancer

Author: Ansam Aladdin Al-Bayatti
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2006 Volume: 48 Issue: 4 Pages: 421-424
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: To shade a light on certain tumor markers and their sensitivity and specificity in determination of pancreatic cancer.
Patients & Methods :- A total of 35 patients with pancreatic cancer were studied between June 2003 and April 2004 in Specialized Surgical - Baghdad Teaching Hospital . These patients were compared with other 25 non malignant G.I diseases patients as well as 35 healthy controls . The serum was estimated for CAI 9-9 , and CEA by ELFA (Enzyme Linked Fluorescent Assay) method and CPR by ELISA method.
Results :- Five patients with pancreatic cancer were excluded from this study because they were beyond surgery.The results show that there is significant differences between serum level of CAI 9-9 in pancreatic cancer patients as compared with the non malignant G.I disease patients group and control (P< 0.05). While for the determination of CEA there is also significant difference between the pancreatic patients group as compared with the non malignant G.I patients group and control group (P< 0.05). As for the result of CRP there is also significant difference between the pancreatic patients group and the non malignant G.I patients group and control group (P< 0.05) .
Conclusion :- Significant differences were found in the result of the tumor markers CA 19-9 , CEA , and CRP studied in patients with pancreatic cancer as compared with the other non malignant G.I patients and controls . The sensitivity for using all the mentioned parameters was 90% were as the specificity was 75%

Keywords

Pancreatic tumors --- CA 19-9 --- CEA --- CRP


Article
CEA, CA19-9 & A-FP as tumor markers for colorectal carcinoma

Authors: Ansam A. AL-Bayatti --- khdier AL-Rawak --- ragad I.AL-Masral
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2006 Volume: 48 Issue: 1 Pages: 36-40
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract


Article
Prevalence of Matrix metalloproteinase-9 in Breast Cancer As a Marker of Prognosis
فحص البروتينيز المعدني الحشوي (MMP-9) 9- كمؤشر حيوي في تشخيص سرطان الثدي

Author: Wasan A.Bakir1 Zaina F.Ashoor2 Noor H.Ismil1 Ayda M.Majeed1
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2014 Volume: 13 Issue: 2-2 Pages: 266-272
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Matrix metalloproteinase-9 (MMP-9) is regarded as important for degradation of the basement membrane and extracellular matrix during cancer invasion and other tissue-remodeling events. the aim of this study is to investigate and compare the expression of MMP-9 in human breast adenocarcinoma with fibroadenoma. In this study we evaluate the prognostic value of MMP-9, by in situ hybridization staining in a series of 30 breast cancer tissues. Both mean percentage of MMP-9 MRNA and scoring of it,s expression in normal and cancer, showing an increased expression of MMP-9 was significantly high in tumor compared with control samples, with extensive score among breast cancer tissues. This study shows that MMP-9 expression in breast cancer is associated with better prognosis.

يمثل البروتينيز المعدني الحشوي 9-انزيماً مهما في عملية تحلل الغشاء القاعدي والحشوات بين الخلايا خلال مرحلة انتشار السرطان. هدفت هذه الدراسة لمقارنة مستوى تعبير البروتينيز MMP-9 في سرطان الثدي الغدي والاورام المتليفة وذلك من خلال استخدام تقنية التهجين خارج الخلايا لثلاثين نسيجاً تعود الى عينات من سرطان الثدي وأخرى طبيعية. بينت النتائج بأن مستوى تعبير البروتينيز MMP-9 كان عاليا معنويا في عينات السرطان مقارنة مع العينات الطبيعية مما يجعل هذا البروتين مؤشر حياتي مهم في التشخيص المبكر لسرطان الثدي.


Article
Urinary level of Matrix Metalloproteinase (MMP-9) as a biomarker in cystitis and schistosomal chronic cystitis patients

Author: Huda Sadoon Jassim AL-Biaty
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2016 Volume: 15 Issue: 2 Pages: 52-55
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Cystitis means inflammation of the bladder, specifically inflammation of bladder wall. Evaluating the level of urinary MMP-9 as a prognostic biomarker in cystitis (schistosomal and non schistosomal) was the aim of the study. Urine samples and bladder biopsies were collected from 50 cystitis patients who were included schistosomal chronic cystitis and non schistosomal cystitis and also from 38 healthy individuals as control. Urinary concentration of MMP-9 was measured by ELISA technique. Specificity and sensitivity of marker were also calculated. The results showed that MMP-9 urinary level was significantly increased in cystitis patients (3842.90pg/ml) compared to healthy (634.80pg/ml), there was a significant differences in the mean levels of urine MMP-9 for different age groups of patients, but non-significant between females and males. MMP-9 was elevated in both schistosomal chronic cystitis and non-schistosomal cystitis patients and this elevation of marker was higher in schistosomal chronic cystitis but with non-significant, also urine MMP-9 showed significant increase in males than females schistosomal cystitis, and statistical differences between age groups. Matrix Metalloproteinase was specific (87.47%) and was more sensitive (93.22 %) in cystitis patients. We concluded that MMP-9 has a role in inflammation processes of cystitis.

Keywords

MMP-9 --- Cystitis --- Schistosoma --- Inflammation --- Urine --- Biopsy


Article
Determination of Carbohydrate Antigen 19‑9 Level in Sera of Iraqi Patients with Type 2 Diabetes Mellitus

Authors: Russul Riedh Al‑Hamaoy --- Hassan H. Al‑Saeed --- Mahmood Shakir Khudhair
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2019 Volume: 18 Issue: 1 Pages: 20-23
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Background: Diabetes mellitus is a major medical problem worldwide that can be qualified as the last stage of chronic pancreatitis; onthe other hand, chronic pancreatitis is considered as a risk factor for pancreatic cancer. Therefore, the evaluation of  carbohydrate antigen 19‑9 (CA 19‑9) level in patients with diabetes mellitus makes it imperative to find normal range for CA 19‑9 level for this patient to eliminate the additional interventional approaches. Objectives: The objectives of this study were to define the normal range (cutoff value) of CA 19‑9 in type 2 diabetic patients using enzyme‑linked immunosorbent assays. Materials and Methods: This study included 80 patients diagnosed as type 2 diabetes mellitus (T2DM) with mean age (46.5625 ± 1.1054 years) who were divided into two groups. In Group I, 40 patients with T2DM have a mean duration of (6.6 ± 0.9421 years) and take medication. Group II consisted of 40 patients who were newly diagnosed with type 2 diabetic and do not take medication. Totally, 40 healthy individuals with mean age (44.7 ± 1.4539) were classified as the control group.Results: The mean ± standard error (SE) serum level of CA 19‑9 in patients with T2DM in Groups I and II was 30.22933 ± 3.2434 U/ml and32.58443 ± 2.7997 U/ml, respectively, which was significantly higher than the mean ± SE serum level in control group (6.4328 ± 1.3087 U/ml).When using a serum CA 19‑9 concentration of 49.5 U/ml as a cutoff value to differentiate between T2DM and pancreatic cancer, sensitivity was 88.8% and specificity 77.5%. Conclusion: Define the normal range (cutoff value) of CA 19‑9 in type 2 diabetic patients is useful in discriminating pancreatic cancer patients from type 2 diabetic patients.

Listing 1 - 10 of 81 << page
of 9
>>
Sort by
Narrow your search

Resource type

article (81)


Language

English (54)

Arabic (16)

Arabic and English (9)


Year
From To Submit

2019 (5)

2018 (6)

2017 (9)

2016 (8)

2015 (14)

More...