research centers


Search results: Found 35

Listing 1 - 10 of 35 << page
of 4
>>
Sort by

Article
Pain In Patients With Multipe Sclerosis

Authors: Mo'taz Fayrouz Abd --- Khalid I. Mussa*.)
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 73-76
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: pain is frequently listed among initial symptoms of MS or an occurring in the course of the disease.
Patients and Methods: one hundred thirty MS patients diagnosed according to Macdonald's criteria compared with 115 matched age and sex control were interviewed about pain Neuropathic, somatic and headache.
Results: Neuropathic pain was significantly higher in MS than control group, while LLD and ARP were of no significance difference between two groups. For somatic pain there was significant increase in MS.
Conclusion: pain is common in MS especially LLD. There is no significant difference between pain subtypes and duration of disease and FS, EDSS.


Article
CHLAMYDIA PNEUMONIAE: THE POTENTIAL CAUSE OF MULTIPLE SCLEROSIS

Authors: Alaa H. Khaliel علاء حسن خليل --- Ahmed A.H. Abbas احمد عبد الحسن عباس
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 2 Pages: 131-136
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Background:Multiple sclerosis is an autoimmune disease, its etiology until know is unknown. Many studies suggested that the environmental risk factors one of them is chlamydia Pneumoniae may play a role in the initiation of the disease.Objectives:To investigate the relationship between previously Chlamydia Pneumoniae infection and multiple sclerosis disease initiationMethods:Sixty patients with multiple sclerosis (30 newly and 30 previously diagnosed), their ages ranged from 13 to 58 years were enrolled in the present study. They attended seeking for treatment or for the diagnoses of multiple sclerosis in outpatient clinic at the Medical City, Baghdad Teaching Hospital, Baghdad in the period from December 2014 till March 2015. In addition, thirty healthy volunteers their gender and ages were matched with patients group were participated as a control. We measured the anti chlamydia Pneumoniae IgG by ELISA technique.Results:The chlamydia Pneumoniae positivity in the multiple sclerosis patients was considerably higher than the control group but the variation was not significant (p > 0.05) and there was no difference between the previously and newly diagnosed multiple sclerosis patients.Conclusion:There is no statistically significant relationship between previously chlamydia Pneumoniae infection and MS disease.Keywords:Multiple sclerosis, chlamydia Pneumoniae


Article
ASSOCIATION OF MULTIPLE NEUROLOGICAL DISEASES IN YOUNG FEMALE: CASE REPORT
مزاملة لعدد من الأمراض العصبية لفتاة صغيرة السن: حالة مسجلة

Authors: Abdul-Kareem A.M عبد المطلب عبد الكريم --- Hasan A. Al-Hamdani حسن عزيز الحمداني
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2005 Volume: 4 Issue: 1 Pages: 111-114
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

A 20-year-old female was diagnosed as a case of epilepsy since 1995. The patient was diagnosed as a case of myasthenia gravis in April 2002. Since 1999, her complaint became more announcing over two years. Until April 2002, when the patient consulted a neurologist, she was diagnosed as case of Myasthenia gravis. The patient diagnosed as a case of multiple sclerosis then after. The key to the clinical criteria for the diagnosis was lesions disseminated in space and in time. This case may represent an association of multiple neurological diseases of dysimmune reaction.Key worlds: Multiple Sclerosis, Myasthenia and epilepsy

الحالة لفتاة تبلغ من العمر عشرون عاما" شُــخصت إصابتها بمرض الصرع سنة 1999 و كان نوع الصرع، صرع أكبر بدون علا مات بؤرية.في نيسان 2002 شُــخص للمريضة أصابتها بمرض وهن العضلات الوبيل. فمنذ سنة 1999 حيث بدأت المريضة تعاني من علامات تزداد شـدة بشـكل مسـتمر متمثلة بازدواج النظر، هطول الأجفان، صعوبة في المضغ و البـلـع و صعوبة في صعود السـلم و تمشـيط شـعـر الـرأس. العلامات كانت أكثر وضوحا" عند المسـاء. و قد أثبِت وجود المرض بواسطة الفحـص الكهروفسلجي و بواسطة ملاحظة الاستجابة لعقار النيوستكمين وريديا". و قد وصِــف العلاج بواسطة عقار النيوستكمين عن طريق الفم و أظهرت المريضة تحســن ملحوظ.في حزيران 2002 أدخلت المريضة إلى المسـتشـفى بعد ظهور أعراض جديدة مختلفة عن السابق متمثــلة باضطراب التوازن و صعوبة القيام بالأعمال الدقيـقـة بواسـطة اليد و صعوبة في المشي. أدخلت المريضة مرة أخرى إلى المستشفى في تشـرين الأول نتيجـة حصول شـلل في الجهة اليسـرى من الجسم مع خدر في نفس المنطقة. العلا مات كانت تزيد شـدة أثناء تواجدها في المسـتشـفى.أظهر الفحص السـريري وجود شـلل في العصب السـابع للجهتـين ذا منشأ حركي علوي مع نشـاط لردود الأفعال الوترية في جهتي الجسـم مع ضعف حركي ذا منشأ علوي بالأضافة إلى اعتلال في المخيخ مع اضطراب في الجهاز الحسـي خصوصا" في إحساس التذبذب.أظهر فحص العصب البصري المثار على وجود زيادة في الاسـتثارة لكلا العينين. فشـخص الإصابة بمرض تصلب الأعصاب المنتشر على أساس كون الحالة تمثل انتشـار الضرر في المكان و الزمان للجهاز العصبي المركزي. أعطي عقار مثيل بردنيزولون للمريضة و أظهرت اسـتجابة واضحة.الأستنتاج: هذه الحالة قد تمثل مزاملة لعدة أمراض عصبية كأوجه مختلفة للاضطراب المناعي.


Article
The Role of Gender in Early Onset Relapsing Remitting Multiple Sclerosis

Author: Hasan Azeez Al-Hamadani
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 2 Pages: 250-257
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND: Multiple sclerosis is an autoimmune inflammatory demyelinating disorder of the central nervous system. Multiple sclerosis is now universally found to be more prevalent in women than menOBJECTIVE: The aim of the study is to clarify the role of gender in early onset multiple sclerosisPATIENTS AND METHODS: This retrospective study was conducted in the multiple sclerosis clinic archive system in the Medical City Hospital in Baghdad, Iraq. Data collection was carried out between March 2008 and March 2009. The patients diagnosed to have relapse remitting multiple sclerosis according to the revised McDonald’s diagnostic criteria for multiple sclerosis, and onset of disease must be before the eighteenth birthday. For each patient, the following information was gathered: age, gender, date of onset, and date of second attack, presenting symptom, and extended disability status scale and the date, and type and location of MRI lesions. A p-value <0.05 was considered the cutoff point to determine significant findings. RESULTS: Forty-eight of the patients where females (62.3%) and 29 patients where males (37.7%), with a female: male ratio 1.6:1. No significant difference was found regarding distribution of gender in each age group, and no significant difference was found when age at onset was compared between males and females, although in male patients a shift to children and a shift at adolescence in female were observed The comparison of different radiological sites between males and females shows a significant difference with more males having infratentorial lesions compared with females (P=0.033). No significant difference was found between the two genders regarding, age at onset the presenting symptom, mode of onset and no significant difference was found when interval between the first and second attack was compared between males and females. CONCLUSION: Female preponderance was highest for subjects with disease onset at adolescents. No significant difference was found when age at onset was compared between males and females, although in male patients, a shift to children and a shift at adolescence in female were observed. A significant difference in the time, between first and second attack between males and females. A significant difference in the MRI findings was the finding that males had a higher incidence of infratentorial lesion than females.


Article
Paramyxoviruses and Multiple Sclerosis
) ومرض تصلب الاعصاب المتعدد paramyxo viruses فيروسات ال (

Authors: Eman abdulrahman Mahmood** أيمان عبد الرحمن --- Ghassaq Tariq Sadiq غسق طارق*
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2012 Volume: 9 Issue: 3 Pages: 500-503
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Multiple Sclerosis (MS) is a progressive neurological disease characterized by periods of quiescence and exacerbation, epidemiological data suggest the notion that MS is an acquired autoimmune disease caused by environmental factors, probably infectious, in genetically susceptible individuals.The submitted research was attempted to study the possible viral (Paramyxoviruses) role in MS, the sera of 57 MS patients were assayed for anti-measles and anti-mumps IgG antibodies using ELISA technique, the results were compared in order to establish the presence or absence of a significant difference regarding both number of positive cases and antibodies titer between the two groups, the results revealed that there is no in number of measles positive cases in both MS patients and controls while a significant difference in number of positive cases of mumps and measles anti-measles IgG titer and a highly significant difference regarding mumps IgG Abs titer between the two studied groups, this may be considered as a preliminary indicator to the role of those two paramyxoviruses in MS.

يعتبر مرض تصلب الاعصاب المتعدد احد الامراض العصبيه والتي تتميز بفترات من السكون والهيجان ويعتقد انه احد امراض المناعه الذاتيه المتسببه عن احد العوامل البيئيه ومنها الاصابات الفيروسيه في الاشخاص المهيئين وراثيا لظهور المرض.البحث المقدم يهدف لدراسة دور بعض الفيروسات من عائلة ال(paramyxo ) وهما فيروسي الحصبه والنكاف,حيث تم جمع 57 عينة دم لاشخاص مصابين بالتهاب الاعصاب المتعددمن مستشفى بغداد التعليمي مدينة الطب بغداد و34 عينه لاشخاص غير مصابين بهذا المرض كمجموعة سيطره وتم فحص هذه العينات للاجسام الضاده نوع (IgG ) لفيروسي الحصبه والنكاف ومقارنة نتائجهم من حيث عدد الاصابات والحجم العياري للاجسام المضاده (antibody titer ) ومقارنتهم لملاحظة وجود فرق معنوي بين المجموعتين من عدمه,اوضحت النتائج عدم وجود فرق معنوي في عدد الاصابات بالحصبه بين المجموعتين بينما الفرق معنوي فيما يخص عدد المصبين بالنكاف اما قياس الحجم العياري للاجسام المضاده للمجموعتين فقد اثبت ان الفرق معنوي بما يخص فيرس الحصبه بينما تم تسجيل فرق معنوي عالي لفيروس النكاف,مما تقدم ممكن ان نستنتج ان للاصابه الفيروسيه بشكل عام دور في مرض تصلب الاعصاب المتعدد بشكل مباشر او غير مباشر وخصوصا فيروس النكاف.


Article
Comparison of familial and sporadic multiple sclerosis in Iraqi patients
تقييم علامات الاضطرابات المناعية والايضية عند مرضى السكري أيجابي الاجسام المضادة لخلايا الجزر

Author: Hasan A. Al-hamadani حسن عزيز حسن الحمداني
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2012 Volume: 54 Issue: 1 Pages: 1-6
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining susceptibility to MS. The exact effect of the former is intended for investigation in our study. Objectives: The objective of the study is to compare the demographic features, clinical presenting features, and clinical course between familial and sporadic cases of MS.Materials and Methods: this is a retrospective cohort study conducted in Multiple Sclerosis Center in the Medical City in Baghdad. The records of the MS center in Baghdad Teaching Hospital were surveyed, and data from 13 patients with positive family history of MS, and 13 patients with out family history of MS was analyzed.Results: Regarding the clinical presentation, for those with family history of MS the common presenting symptoms were sensory symptoms and transverse myelitis, and those without family history of MS was pyramidal, for those with family history of MS 11 patients had initial course of relapsing remitting MS ( 84.6%) ,of them 4 patients progressed into secondary progressive MS (36.4%); 2 patients had primary progressive MS as initial course, for those with negative family history of MS 12 patients had initial course of relapsing remitting MS, of them 5 patients progressed into Secondary progressive MS (41.6%); 1 patients had primary progressive MS as initial course (7.7 %.). No significant difference was found in the investigated parameters, except for the inverse relation between age of onset and lag time to diagnosis.Conclusion: Familial MS do not significantly differ from sporadic MS in terms of the demographic patterns and clinical course and presentation. This is not the case for the relationship between the age of disease onset and lag time to diagnosis.

الخلفية: التصلب اللويحي واحد من الاضطرابات العصبية الواسع الانتشار بشكل متزايد. هناك دراسات للعوامل الوبائية والأسرية وتأثير العوامل الوراثية والبيئية في تحديد قابلية الاصابة بالمرض. هذه التاثيرات تم التحقق منها بدقة في دراستنا. الأهداف: الهدف من هذه الدراسة مقارنة الخصائص الديموغرافية، والاعراض السريرية، ومسار المرض بين الحالات ذات التاريخ الأسري والمتفرقة من المرض. المواد والطرق: هذه المجموعة من المرضى وبأثر رجعي درست في "مركز التصلب" في مدينة الطب في بغداد. تم مسح سجلات المركز في "مستشفى بغداد التعليمي"، وقد تم تحليل البيانات ل 13 مريضا لهم تاريخ أسري إيجابي من المرض. النتائج: فيما يتعلق بالاعراض السريرية لمن لديهم تاريخ عائلي من المرض , فأن أكثر الاعراض شيوعا هي الأعراض الحسية وأعتلال الحبل الشوكي، اما المرضى بدون تاريخ عائلي فان الاعراض الهرمية هي الاكثر شيوعا، لمن لديهم تاريخ عائلي للمرض 11 كان المسار المرضي هو الانتكاسة والتخفيف، و 4 مرضى للتدريجي الثانوي و 2 للتدريجي الأساسي لكن لذوي التاريخ العائلي السلبي 12 مريض كانو من الانتكاسة والتخفيف ، خمسة مرضى للتدريجي الثانوي وكان مريض واحد من النوع التدريجي الأساسي. لا اختلاف كبير في معالم التحقيق، باستثناء العلاقة العكسية بين سن البداية وتأخر وقت التشخيص.الاستنتاج: التاريخ الأسري ليس له تأثير كبير واختلاف من حيث الأنماط الديمغرافية والمسارات السريرية والاعراض الاولية. استثناءا هناك فرق بالنسبة للعلاقة بين سن المرض وقت بداية وتأخير للتشخيص.


Article
Clinically Isolated Syndrome of Early Onset Multiple Sclerosis in a Sample of Iraqi Patients

Author: Hasan Azeez Al-Hamadani
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 3 Pages: 397-401
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:The first acute demyelinating event without encephalopathy, termed a clinically isolated syndrome, can manifest with signs and symptoms caused by a single lesion (monofocal clinically isolated syndrome) or with polyfocal features, implicating multiple lesions. It is becoming increasingly recognized that MS affects children and adolescents, with many of these patients receiving the diagnosis and initiating therapy prior to their 18th birthday(2).OBJECTIVE:To evaluate the clinically isolated syndrome in individuals with early onset of multiple sclerosis.MATERIALS AND METHOD:The records of the multiple sclerosis centers in Baghdad teaching hospital have been surveyed. The study enrolled 77 patients who had early multiple sclerosis (onset before age of 18 years), their clinically isolated syndrome data have been analyzed.RESULTS:Two thirds of the patients were female (a female/male ratio of 1.6:1). Forty eight of the patient where female (62.3%) and twenty nine patients where males (37.7 %). Mean age at onset was 14.95 years. Seven patients where children (age below 10years) (9.1%) and seventeen patients where adolescents (age 10 to 18 years) (90.9%) at onset. The most common presenting clinically isolated syndrome was optic neuritis (35.8%) followed by brain stem lesion. Fifty nine patients had monofocal presentation (76.6%) and eighteen had polyfocal presentation (23.4%). forty seven patients had complete improvement of the clinically isolated syndrome (61.0%), the rest had partial or no improvement.CONCLUSION:The most common clinically isolated syndrome of early onset Multiple sclerosis is optic neuritis. monofocal clinically isolated syndrome more than polyfocal. Complete improvement is high.


Article
clinical prognostic factors after the first attack of early onset multiple sclerosis in iraq
العلامات السريرية التنبأية بعد الانتكاسة الاولى لمرض تصلب الاعصاب المنتشر المبكر الحدوث في العراق

Author: Hasan A.Al hamadani حسن عزيز الحمداني
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 4 Pages: 358-362
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract


Article
Serum Interleukin-8 and Hs-C Reactive Protein Determination in Iraqi Multiple Sclerosis Patients: Case Control Study

Author: Khawla A. A. AL-Sammariey
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 153-155
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT: BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease caused by a complex disorder that cluster many common diseases in children and adults, leading to chronic inflammatory disease of the central nervous system with morphological hallmarks of inflammation, demylination, axonal loss and gliosis .Factors responsible for MS and its progression are still not fully understood, but it has been suggested that both environmental determinants and genetic susceptibility are involved.OBJECTIVE :The aim of this study is to evaluate the role of inflammatory markers ;hs-CRP and IL-8 in pathogenesis of MS and to see the correlation between them.PATIENTS AND METHODS: Twenty one MS Patients (7male,14 female) attending the MS Clinic at Baghdad teaching hospital, their ages range between( 20-32) years (15) age- and sex- matched healthy control participated in the study. Investigations included serum measurements of high sensitive C-reactive protein (hs- CRP) and interleukin-8 in patients and control groups.RESULTS: The result of the present study showed significant increase in both CRP(p<0.001 ) and IL-8 (p< 0.001 ) in the serum of MS patients compared to control.CONCLUSION: There is evidence that neuroinflammatory process due to elevation of CRP and IL-8 has an important role in MS .


Article
Detection of Human Leukocyte Antigen and Celiac Disease Auto Antibodies in serum of Patients with Multiple Sclerosis
التحري عن مستضدات التوافق النسيجي والاضداد الذاتية لحساسية الحنطة في مصول المرضى المصابين بتصلب الاعصاب المتعدد

Authors: Rana S. Aboud رنا سعدي عبود --- May K. Ismael مي خليل اسماعيل --- Haider J.Mohammed حيدر جاسم محمد
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2014 Volume: 55 Issue: 4A Pages: 1477-1483
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

To determine the important pathogenic role of celiac disease in triggering several autoimmune disease, thirty patients with Multiple Sclerosis of ages (22-55) years have been investigated and compared with 25 healthy individuals. All the studied groups were carried out to measure anti-tissue transglutaminase antibodies IgA IgG by ELISA test, anti-reticulin antibodies IgA and IgG, and anti-endomysial antibodies IgA and IgG by IFAT. There was a significant elevation in the concentration of anti-tissue transglutaminase antibodies IgA and IgG compared to control groups (P≤0.05), there was 4(13.33%) positive results for anti-reticulin antibodies IgA and IgG , 3(10%) positive results for anti-endomysial antibodies IgA and IgG . There were 4 positive results (13.33%) for HLA-DQ8 by using HLA-DQ8 Real-Time PCR test. These results indicated that patients with celiac disease play an important role in pathogenesis of Multiple Sclerosis.

غرض تعيين الدور الامراضي المهم لمرض حساسية الحنطة في قدح العديد من امراض المناعة الذاتية، تم التحري عن (30) شخص مريض يعانون من تصلب الاعصاب المتعدد باعمار تتراوح من (22-55) سنة وتمت المقارنة مع (25) شخص سليم . خضعت جميع عينات الدراسة لقياس مستوى اضداد anti- tissue transglutaminaseAb الصنف ( (IgA,IgG باستخدام تقنية الامتزاز المناعي المرتبط بالانظيم ،وقياس مستوى اضداد reticulinAb-anti الصنف ( IgA,IgG) و anti-endomysial Ab (IgA,IgG) باستخدام تقنية التالق المناعي غيرالمباشر. اظهرت نتائج الدراسة ارتفاعا معنويا0.05) P≤)في تركيزاضداد anti-tissue transglutaminaseAb الصنف (IgA,IgG) مقارنة بمجاميع السيطرة ،كمالوحظ ان هنالك اربعة نتائج موجبة (13.33% ) بالنسبة لاضداد ( IgA,IgG) reticulinAb- antiوثلاثة نتائج موجبة10% بالنسبةلاضداد anti-endomysialAb (IgA, IgG) ، كما أظهرت نتائج الدراسة ان هنالك اربعة نتائج موجبة(13.33%) بالنسبة للHLA-DQ8 باستخدام تقنيةHLA-DQ8 Real time PCR . تشير نتائج الدراسة الحالية بان مرض حساسية الحنطة يلعب دورا مهما في قدح مرض تصلب الاعصاب المتعدد.

Listing 1 - 10 of 35 << page
of 4
>>
Sort by
Narrow your search

Resource type

article (35)


Language

English (27)

Arabic and English (6)


Year
From To Submit

2018 (7)

2017 (3)

2016 (7)

2015 (2)

2014 (6)

More...