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Article
Sildenafil is an Effective Therapy for Treatment of Chilblain in Female Patients with Bacteriological Study of Ulcerative Lesions

Authors: Prof. Dr. Khudhair Khalaf Al-Kayalli --- Burooj Mohammed Razooqi Al-aajem
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 3 Pages: 45-48
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Chilblains, also called pernio or perniosis, are مocalized, tender,inflammatory, erythematous, often itchy lesions, which may blistered or ulcerated, caused by continued exposure to cold above the freezing point.More commonly seen in children, women and persons with low body massindex, with a genetic predisposition. Many prophylactic measures are used, and therapeutic remedies for the treatment of developed chilblains, like nifedipine, diltiazem, nicotinic acid derivatives, tamoxifen and minoxidil topically.Objectives: The aim of the present study was to evaluate the effectiveness of sildenafil in the treatment of chilblains in female patients.Patients and methods: Sixty five female patients with chilblain were seen in a private clinic in Kalar city, Al-Sulaimania Province, Iraq, for the period from the first of October 2014 to the thirty of September 2016, their ages ranged from 10-25 years (mean 16±8). The disease was diagnosed clinically and the patients were evaluated for different data, and identification of bacteria which complicate some patients with ulcerative lesions and all patients treated by sildenafil tablet (50mg, once daily after meal), for 7-10 days and assisted clinically (subjectively) for resolution of the disease.Results: Sixty patients (92.3%) out of (65) studied patients shows complete clearance of the disease clinically within 7-10 days of sildenafil treatment (50mg, tablet, once daily orally after meal). Five patients (7.7%) shows partial improvement of the disease with persistence of the signs and symptoms.Staphylococcus aureus was isolated from 20(30.76%) patients. Ten patients (15.4%) developed flushing and hotness of the face with nasal stiffness and 5 patients (7.7%) developing gastric upset.Conclusion: It was concluded that sildenafil was an effective therapy for the treatment of chilblain in female patients, although it was associated with some side effects.

Keywords

Chilblain --- nifedipine --- diltiazem --- sildenafil --- flushing


Article
Medical Expulsive Therapy for Lower Ureteric Stones: A Comparative Study

Author: Samir Ali Muter
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2010 Volume: 9 Issue: 1 Pages: 47-51
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background Lower ureteric stones and accompanying ureteric colics represent one of the most common medical problems faced by urologist, the treatment usually starts with conservative therapy, however, if the stone fails to pass within 4-6 weeks, a prompts action should be taken to save the kidney, this usually involves one of the minimally invasive therapy options like shock wave lithotripsy (ESWL), of ureteroscopy. However this is not free of risk, and cost, for these reasons, urologists now concentrate on what's called medical expulsive therapy, which means using drugs to enhance stone passage. Objective In this study we evaluated and compared three of the most commonly used drugs, nifedipine, tamsulosin, and sildenafil citrate, for their expulsive role in lower ureteric stones. Methods Through out the period from Feb. 2008 until Nov. 2009, 98 patients with lower ureteric stones were enrolled in this study, they were thoroughly examined and investigated, then randomized into 4 groups, the first group patients received nifedipine, the second group patients received tamsulosin, the third group patients received sildenafil citrate, and the forth group patients served as control. Patients followed up for one month and monitored for stone passage, time of stone passage and number of ureteric colics experienced while on treatment. Data collected and analyzed statistically. Results Only patients on tamsulosin therapy showed a statistically significant improvement in stone passage rate (81.4%), compared to those on nifedipine(69.6%), sildenafil citrate (57.6%), and control (54.5%). Both nifedipine and tamsulosin significantly shortened the time needed for stone passage and reduced the number of ureteric colics, while sildenafil citrate failed to show any beneficial effect compared to control. Conclusions Tamsulosin may have a significant role in enhancing lower ureteric stone passage within shorter time and with less pain, and it is superior to nifedipine, and sildenafil citrate in this regard.


Article
FLOW INJECTION ANALYSIS AND SPECTROPHOTOMETRIC DETERMINATION OF NIFEDIPINEIN PHARMACEUTICAL FORMULATION
التقدير الطيفي للنفديبين في المستحضر الصيدلاني من خلال منظومة الحقن الجرياني

Authors: Intisar Mudhafar alsaeedi انتصار مظفر السعيدي --- Sadeem Subhi Abed سديم صبحي عبد
Journal: iraq journal of market research and consumer protection المجلة العراقية لبحوث السوق وحماية المستهلك ISSN: ISSN/ 20713894/ EISSN/25236180 Year: 2019 Volume: 11 Issue: 1(عدد خاص) Pages: 85-99
Publisher: Baghdad University جامعة بغداد

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Abstract

A new simple and sensitive spectrophotometric method is described for quantification of Nifedipine (NIF) and their pharmaceutical formulation. The selective method was performed by the reduction of NIF nitro group to yield primary amino group using zinc powder with hydrochloric acid. The produced aromatic amine was submitted to oxidative coupling reaction with pyrocatechol and ammonium ceric nitrate to form orange color product measured spectrophotometrically with maximum absorption at 467nm. The product was determined through flow injection analysis (FIA) system and all the chemical and physical parameters were optimized. The concentration range from 5.0 to 140.0 μg.mL-1 was obeyed Beer’s law with a limit of detection and quantitation 1.48 and 4.96 μg.mL-1 respectively. Agoodprecision,low scattering point of the calibration graph and good accuracyin addition, FIA introduced a good linear range with acceptable sensitivity. High correlation coefficient (0.9996) was found. The proposed method was successfully applied to assay NIF and its pharmaceutical dosage also could be utilized for pharmaceutical routine analysis of the drug.

تم وصف طريقة طيفية جديدة بسيطة وحساسة للتقدير الكمي للنفديبين ومستحضره الصيدلاني, حيث انجزت من خلال اختزال مجموعة النايترو للنفديبين لتتحول الى مجموعة امينو اولية بتفاعله مع مسحوق الخارصين وحامض الهيدروكلوريك المركز، تم تفاعل الناتج مع كاشف البايروكاتيكول ونترات ثنائي امونيوم سيريوم الرباعي عن طريق تفاعل الازدواج التأكسدي, مما نتج عنه محلول ذو لون برتقالي تم قياسه طيفيا عند طول موجي 467 نانومتر وقد استعملت منظومة الحقن الجرياني لاجراء التقدير كما تم اختيار الظروف المثلى الكيميائية والفيزيائية، كان منحني المعايرة ضمن مدى 5.0 إلى 140.0 ميكروغرام/ مل مع حد الكشف والقياس الكمي 1.48 و 4.96 ميكروغرام/ مل على التوالي، وتم الحصول على دقة جيدة ونقاط تشتت منخفضة في الرسم البياني لمنحني المعايرة وضبط جيد كذلك قدمت تقنية التحليل بالحقن الجرياني مدى خطي جيد مع حساسية مقبولة، معامل الارتباط كان عاليا (0.9996)، ان الطريقة المقترحة استعملت بشكل ناجح في فحص وتقدير النفديبين وكذلك مستحضره الدوائي.

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