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Article
Therapeutic Evaluation of Spironolactone and Finasteride in the Treatment of Acne Vulgaris

Author: Khalifa E. Sharquie
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 3 Pages: 206-210
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Antiandrogens have been developed to treat acne; spironolactone, an androgen receptor blocker, and finasteride, 5 alpha reductase inhibitor, are two antiandrogens that can be used to treat acne vulgaris.OBJECTIVES:To evaluate the effectiveness and safety of spironolactone , finasteride, and combination of both drugs in the treatment of acne vulgaris.PATIENTS&METHODS:This single blinded uncontrolled clinical therapeutic trial was done in the Department of Dermatology and Venereology – Baghdad Teaching Hospital- in a period from December 2004 to October 2006.The patients were classified according to the number of inflammatory lesions as having mild, moderate and severe acne. Severe acne was excluded from the study. History & close examination were performed to all patients regarding all points related to the disease. Sixty-nine patients with acne were divided into three groups and were instructed to take the following drugs for two months; group A: spironolactone 100 mg/day, group B: finasteride 5 mg/day, and group C: combination of both drugs.The clinical assessment was done by counting the number of inflammatory lesions every two weeks for two months, recording any local or systemic side effects, & comparison between the number of inflammatory lesions before and after treatment was done.RESULTS:Sixty patients had completed this work, whose mean± SD of their ages of the three groups totally was 18.8 ± 2.3 years and for group A, group B, and group C as follow : 19 ± 2.6, 19.3 ± 1.9, and 18.1 ± 2.4 respectively, with 20 patients in each group.Spironolactone was statistically significant in reducing the number of inflammatory lesions, finasteride was beneficial but did not reach a statistically significant level as spironolactone, and combination of both drugs was more effective in the treatment of acne vulgaris than spironolactone alone but did not reach a statistically significant level.CONCLUSION:Spironolactone is a good alternative drug to be used in patients with acne singly or in combination therapy with finasteride.


Article
Sandpaper Dermabrasion for Treatment of Acne Scars and Amateur Tattoos in Dark Skinned Individuals

Author: Ali Waleed Al-Aadamy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 2 Pages: 141-146
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Dermabrasion is an abrasive process used to remove the epidermis and superficial dermis to treat a variety of skin conditions.OBJECTIVE:To evaluate sandpaper as a tool for dermabrasion for the treatment of acne scar and amateur tattoo.PATIENTS AND METHODS:This is an open labeled therapeutic trial. It was conducted at the outpatient department of Dermatology and Venereology - Baghdad Teaching Hospital, during the period between January 2003 and December 2004.Ten patients (seven males and 3 females) were enrolled in this work. Their ages ranged from 20-34 years with the a mean ± SD of 26.80 ± 4.34 years. Five with acne scars on their faces and 5 with amateur tattoos in the upper extremities.. From each patient history was taken and physical examination was performed. Pre-operative medications and instructions were given to each patient. The procedure was done under local anesthesia. Postoperatively all patients were instructed to use steroid-antibiotic ointment and hydroquinon-tretinoin thereafter. Follow up was done after 1weak, 1month, and 3 months. Repeated sessions may be needed 1 month apart.Acne scars: Lesions were assessed for correction of contour (unchanged, partially changed, or completely changed), and for complications that might follow.Amateur tattoos: Lesions were assessed for percentage of pigments removal (70%, 80%, 90%, and 100%), and for complications that might follow.RESULTS:Ten patients completed the study.Acne scar group: Three patients achieved partial change of contour after 2 sessions, while complete change of contour was noticed in 2 patients after 4, and 6 sessions respectively. The procedure resulted in very fine, less noticeable scar with smooth contour of the skin which was acceptable in all patients.Amateur tattoos group: Complete removal of pigments was achieved in one patient, more than 90% in 3 patients, and more than 80% in 1 patient.No significant complications were seen apart from mild erythema and mild infection in one patient with amateur tattoo. Temporary post inflammatory hypopigmentation in two patients with tattoo. Three patients had mild scar after removal of tattoo.CONCLUSION:Sandpaper dermabrasion is an effective mode of treatment for acne scar and amateur tattoo. It is safe in dark skinned people.

Keywords

dermabrasion --- acne scars --- tattoo


Article
Efficacy and Safety of Combined Isotretinoin and Azithromycin for Treatment of Severe Nodulocystic Acne
فعالية وامان عقاري الايزوتريتينوين والازثرومايسين الفموي كعلاج لمرض حب الشباب الشديد التكيسي عند المرضى العراقيين

Author: Samer A. Dhaher,Muhammed R. Luaibi سامر عبدالامير ظاهر
Journal: The Medical Journal of Basrah University المجلة الطبية لجامعة البصرة ISSN: 02530759 Year: 2016 Volume: 34 Issue: 2 Pages: 68-76
Publisher: Basrah University جامعة البصرة

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Abstract

Background: A combination of azithromycin & isotretinoin has been used for treatment of Severe nodulocystic acne before, however, an optimal scheduled doses regimen of such combination remained to be elucidated.Objectives: To evaluate the effectiveness, safety and tolerability of using a new combination of fixed low doses of isotretinoin and azithromycin in an alternative days regimen in treatment of severe nodulocystic acne in Iraqi patients.Patients and Methods: A prospective open-labeled clinical study in which 54 young adult and adolescent patients with severe nodulocystic acne were recruited for the study at the Department of Dermatology in Basra General Hospital during from May-October 2015. The patients were received a combination of fixed dose of isotretinoin 20 mg thrice weekly and 500 mg azithromycin given orally thrice weekly on alternating days and one day off for 12 weeks. The participants was assessed before, during and after treatment. The calculation of percentage and scoring of reduction of acne lesions was also carried out.Results: There was a marked reduction in the inflammatory lesions at the first 4 weeks of the treatment, with a significant clearance of 38.4% of the papular lesions, 63.5% of pustular and 43% of the nodular lesions. At the end of the study, there was a significant reduction in the number of the inflammatory lesions, with the clearance of 76% of the papules, 96% of the pustules and 86% of the nodules. The most frequent adverse effects reported was dryness of face and lips.Conclusion: Fixed dose of azithromycin 500 mg combined with isotretinoin 20 mg on alternating day regimen proved to be effective, safe & well tolerated regimen for treatment of severe nodulocystic acne with high score of patient satisfaction.

الخلفية: بالرغم من فعالية عقاري الايزوتريتينوين الازثرومايسين كعلاج لمرض حب الشباب الشديد التكيسي الا ان تحديد الجرعة المناسبة لكلا العقارين بحاجة الى توضيح وتحديد اكثر.اهداف البحث: تقييم فعالية وامان عقاري الايزوتريتينوين والازثرومايسين بجرع ثابتة ومحددة كعلاج لمرض حب الشباب الشديد التكيسي عند المرضى العراقيين.طريقة اجراء البحث والمرضى: دراسة مستقبلية غير مقارنة شملت 54 مريضا مصابا بمرض حب الشباب الشديد التكيسي, اجريت الدراسة في مستشفى البصرة العام للفترة من مايس ولغاية تشرين الاول 2015. اعطي المرضى جرع ثابتة من الايزوتريتينوين 20 ملغم ثلاث مرات اسبوعيا بالتناوب مع الازثرومايسين 500 ملغم ثلاث مرات اسبوعيا. تم تقييم الاستجابة للعلاج شهريا بواسطة حساب نسبة اختزال اعداد الآفات الجلدية مع تسجيل اي اثار جانبية مصاحبة.النتائج: كان هناك اختزال واضح في اعداد ونسب الآفات الجلدية ابتداء" من نهاية الشهر الاول لبدء العلاج حيت انخفضت نسبة الحطاطات الى 38.4 % ونسبة البثور الى 63.5% والتكيسات بنسبة 43%. في نهاية الدراسة كان هناك انخفاض بنسبة 76% في الحطاطات, 96% بنسبة البثور و 86% بنسبة التكيسات. كان جفاف الجلد والشفتين هي الاثار الجانبية الاكثر تسجيلا.الاستنتاجات: ان عقاري الايزوتريتينوين بجرعة 20 ملغم ثلاث مرات اسبوعيا بالتناوب مع الازثرومايسين بجرعة 500ملغم ثلاث مرات اسبوعيا علاجا فعالا وامينا لمرض حب الشباب الشديد التكيسي

Keywords

Isotretinoin --- Azithromycin --- Acne


Article
Study of bacterial causative agents of acne and the effect of some antibiotics on them
دراسة المسببات البكتيرية لمرض حب الشباب ودراسة تأثير بعض انواع المضادات الحياتية على الاحياء المعزولة

Author: Lubna Muhi Rasool لبنى محي رسول الطائي
Journal: Al-Fatih journal مجلة الفتح ISSN: 87521996 Year: 2017 Volume: 13 Issue: 72 Pages: 60-69
Publisher: Diyala University جامعة ديالى

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Abstract

This study was designed to determine the percentage and the main causative agent causing acne among Iraqi patients aged between 15 to 40 years and complaining from different stages of acne in Baghdad. Results showed that the percentage of infection was 47 % the main causative agents were Staphylococcus spp. including (S.aureus , S. epidermedis) and other than Staphylococcus which includes(Spedomonas , E.coli , Klebsiella and ά-hemolytic streptococci ) .Regarding the age factor ,results showed that the highest infection rate was among the age group (15-20 years ) and (20 -25 years ) (64.89%)and (15.95%)respectively while the lowest was in (25 – 30 years ) and (30 -40 years) (12.76%) and( 6.38) respectively . All bacterial strains isolated from patient were submitted to sensitivity test, results showed various reactions towards different types of antibiotics used in the study.

صممت هذه الدراسة لتحديد نسبة الاصابة وألاحياء المجهرية المسببة لمرض حب الشباب عند المرضىمن عمر 15-40 سنة والذين يعانون من مستويات مختلفة من الاصابة في مدينة بغداد , أظهرت النتائج ان نسبة الإصابة 64.19 % من مجموع المرضى المشمولين بالدراسة وقد تم تحديد نوع الاحياء المجهرية المسببة للمرض عن طريق زرع الدم فوجد انها, بالدرجة الاساس الى عائلة البكتريا المعوية والتي شملت تعود Enterobacter, Klebsiella , E.coli, Pseudomonas) وتم ايضا عزل أنواع بكتيرية لا تعود الى العائلة المعوية مثل Streptococcus pneumonia , Staphylococcus aureus , Staphylococcus epidermidis , _ hemolytic streptococci. بالنسبة الى عامل العمر أظهرت النتائج اان الفئة العمرية (15-20 سنة ) شهر كانت ألاكثر عرضة للأصابة بنسبة بلغت 64,89 % تلتها الفئة العمرية الاكبر قليلا (20-25 سنة ) بنسبة بلغت 15,95% فيما كانت الفئة العمرية (30-40 سنة ) ألاقل عرضة للأصابة بنسبة بلغت 6,38% كل السلالات البكتيرية المعزولة تم أخضاعها للأختبار الحساسية لتقدير مدى أستجابتها لأنواع مختلفة من مضادات الحياة وقد أظهرت النتائج أن كل سلالة استجابت بشكل مختلف عن غيرها من السلالات وتم الحصول على مدى واسع من ألاستجابات للأنواع المستعملة في هذه الدراسة .

Keywords

Acne --- حب الشباب


Article
Cryotherapy for The Treatment of Acne Keloidalis (A Clinical Interventional Therapeutic Trial)

Author: Ihsan A. Al-Turfy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 3 Pages: 425-428
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Acne keloidalis is a condition characterized by follicular-based papules and pustules that form hypertrophic or keloid-like scars. It typically occurs on the occipital scalp and posterior neck and develops almost exclusively in young people with dark skin Unlike true acne vulgaris, comedones are not seen . The condition has a great psychosocial impact.The exact etiology of AK is unclear. It is thought that chronic irritation from coarse, curly hairs in the skin leads to inflammation and development of these lesions. It has also been shown that men who have haircuts more frequently than once a month are at higher risk of developing acne keloidalis.OBJECTIVE: To assess the efficacy of liquid nitrogen cryotherapy for the treatment of acne keloidalis.PATIENTS AND METHODS:It is a clinical interventional therapeutic study done in the period from Jan 2010 till Dec 2012 in Al-Noor Hospital/ Alain City UAETwenty male patients with acne keloidalis were treated through several sessions of cryotherapy. Their ages ranged between 23 and 34 years with a mean of 28.2year +/- SD=3.93.Patients were divided into three groups: mild, moderate, and severe.RESULTS:Group one (mild, every patient has less than10 nodules): total no. of nodules was reduced from75 to 26 .t-test was done for this group with a p value=0.0000026. Group two (moderate, every patient has between 10 and 20 nodules): total no. of nodules was reduced from 86 to 34 with a p value = 0.00011.Group three (severe, every patient has more than 20 nodules) : total no. of nodules was reduced from 59 to 38 with a p value =0.015.Patients satisfaction was also done and 15 patients (75%) were satisfied.CONCLUSION: Cryotherapy was a good therapeutic option with mild side effects and acceptable patient satisfaction. .

Keywords

KEYWORDS :acne --- keloid --- cryotherapy


Article
Scarring and None Scarring Facial Acne Vulgaris and the Frequency of Associated Skin Diseases

Authors: Khalifa E. Sharquie --- Khalil I. Al-Hamdi --- Adil A. Noaimi --- Razan A. Al-Battat
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 4 Pages: 332-338
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Acne vulgaris(AV)is chronic inflammatory disease of pilosebaceous unit of young people. Patients with acne with or with out scarring might differ in regard to their immunological background from those free from acne.OBJECTIVES:To evaluate the problem of facial AV especially patients with scarring and to determine the frequency of associated skin diseases and to be compared with acne free control.METHODS:A cross sectional randomized controlled epidemiological study was conducted from Oct.2005-Oct. 2006.Three hundred students from Basra University; 132 (44%) males and 168 (56%) females were enrolled, their ages ranged from 18-25 (20.9±1.8) years. They were divided into: Group A those free from acne (98 individuals),Group B with non scarring facial AV (96 patients), and Group C with scarring facial AV (106 patients). History and examination were done for their acne, scarring acne and associated skin diseases. Allen and Smith grading system for AV were used, and a new invented multiparametric scoring system for scarring acne was applied.RESULTS:AV was in 98(73.24%) males and 104 (61.9%) females. Scarring was 54 (50.95%) males and 52 (49.05%) females. Greasy skin was the most common type among Group B 67 (69.8%) versus 39 (39.8%) among Group A(P=0.000029) and was more common among Group C 84(79.2%) (P=0.00000001).Family history of AV was nearly similar in A and B Groups 55(57.29%) and 56 (52.83%) respectively, while in Group A was 39 (39.79%). Family history of scarring acne was in 35(33.02 %) of Group C, 16 (16.66 %) of Group B, and 3 (3.1%) in Group A; (P=0.00000017). The age of onset was similar in A and B Groups between 15-16 years. Majority of patients in Group B had non inflammatory type or mild inflammatory (papular) 65 (67.8%) patients, most of case were mild and moderate 86 (89.58%) patients, while high percent in Group C had inflammatory type 95 (89.62%), and more than half of them had severe and very severe types upon grading 56 (52.8%). The aggravating factors were similar in A and B Groups with stress and hot weather being the leading aggravating factors. Squeezing and digging habit was in 53 (50%) in Group C versus 23 (23.95%) in Group B (P=0.00024). In most cases of scarring acne, scarring was mild and moderate 85 (80.19%), and the most common type scars was the flat hyperpigmented [50 (47.17%) and 66 (62.26%) respectively].The most common effect of scarring acne on psyche was mild discomfort and mild dysmorphophobia 75 (70.75%).Associated skin diseases were more common among Group A 31 (31. 63%) than among Group B 22 (22.91%) and least common among Group C 14 (13.20%) (P=0.0067) and they were mainly dermatitis and skin infections.CONCLUSION:AV might reflect the immunological status especially among patients with scarring. The frequency of skin diseases was much less among patients with scarring acne


Article
Different Aspects of Acne in Patients Attending the Department of Dermatology and Venereology at Rizgary Teaching Hospital in Erbil
جوانب مختلفة من حب الشباب لدى المرضى الذين يراجعون قسم الأمراض الجلدية والتناسلية في مستشفى رزكاري التعليمي في أربيل

Authors: Intiha Mohamad Almousuly --- Ala’a Abdulrahman Sulaiman
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 3 Pages: 21-24
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background: Acne is a common skin disease of adolescence. It is caused by inflammation of the pilosebaceous units, characterized by comedones, papules, pustules, inflamed nodules and it may result in scarring.Objective: This study was performed to define the different aspects of acne in patients attending the department of dermatology and venereology in Rizgary Teaching Hospital.Methods: This study is a descriptive case- series hospital- based study, conducted on 200 patients with acne attending the department of dermatology and venereology in Rizgary Teaching Hospital in Erbil.Results: The number of female patients with acne was 145 and male patients were 55. Acne of moderate severity was the commonest type, it was found in 57% and 64% of the patients had mixed types of lesions. Seborrhea was present in 84% of patients. Hirsutism was present in 44% of female patients and pre-menstrual flare-up was found in 73% of females. A significant relation was found between gender and degree of severity of acne. Also a significant relation was found between seborrhea and the acne severity.Conclusion: This study showed that acne of moderate severity was the commonest type. Females made the majority of our acne patients. Multiple exacerbating factors were found to be contributing.


Article
Serum Trace Elements (Zinc, Copper and Magnesium) Status in Iraqi Patients with Acne Vulgaris :( Case- Controlled Study)

Authors: Ali Y. Majid --- Zainab N. H. Anbar --- Basil OM Saleh
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 2 Pages: 44-49
Publisher: Baghdad University جامعة بغداد

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Abstract

Recently on the dermatological fields, the serum levels and the roles of Zn, Cu and Mg have been studied especially in acne vulgaris, but the results were controversial. The aim of the present study is to investigate a relationship between the severity of acne and the serum levels of zinc (Zn), copper (Cu) and magnesium (Mg) and to demonstrate the status of serum levels of zinc, copper, and magnesium in Iraqi male patients with acne vulgaris and to compare it with those of healthy controls.This case controlled study was conducted in the Department of Dermatology and Venerology and in the Poisoning Consultation Center of Baghdad Teaching Hospital between May 2009 to January 2010. Forty- five male patients with acne vulgaris, their ages ranged from 18-30 (21.82±3.77) years and 45 healthy male subjects as controls, their ages ranged from 18-30 (22.18±3.85) years were included in this study. Patients were subdivided into three groups according to the severity of their acne; mild acne group (n=15), moderate (n=15) and severe acne group (n=15). Investigations included serum estimation of Zn, Cu and Mg in both patient and control groups.The data obtained from this study showed that the (mean±SD) values of serum levels of Zn was significantly decreased in severe acne group compared with controls, mild and moderate type of acne group (P< 0.05). Serum Mg concentration was significantly lower in severe acne group compared with mild and moderate acne group (P< 0.05). With regard to serum Cu, there were no significant differences among groups of patients with acne vulgaris.This study revealed a significant association between serum levels of either Zn or Mg with the severity of acne.

أن مستوى وأھمیة الخارصین والنحاس والمغنیسیوم في مصول المرضى المصابین بالأمراض الجلدیة, وخاصة مرض حبالشباب تم دراستھ ولكن النتائج كانت متباینة.أن ھدف ھذه الدراسة ھو تقییم مستوى العناصر المعدنیة(الخارصین, النحاس, المغنیسیوم)في مصول الذكور العراقیین المصابین بمرض حب الشباب والذكور الأصحاء ودراسة العلاقة بین مستوى ھذه العناصر وشدة حبالشباب.لقد تم أجراء ھذه الدراسة في قسم الأمراض الجلدیة و التناسلیة والمركز الاستشاري للسموم في مستشفى بغداد التعلیمي للفترة٤٥ ذكر مصاب بحب الشباب تتراوح أعمارھم بین ( ١8 30 سنة), المعدل . ٢ ولغایة كانون الثاني ٢٠١٠ ٠٠ من أیار ٩٣,٧٧ ) سنة و ٤٥ ذكر صحیح(مجموعة السیطرة) بنفس الفئة العمریة ( 18 30 – ٢ +الانحراف المعیاري لأعمارھم ھو ( ١,٨٢٣,٨٥ سنة) تم شمولھم في ھذه الدراسة. أن مجموعة المرضى تم تقسیمھا - سنة), المعدل +الانحراف المعیاري لأعمارھم ھو( ٢٢,18إلى ثلاث فئات حسب شدة حب الشباب: فئة حب الشباب النوع البسیط وعددھم ١٥ , فئة حب الشباب النوع المتوسط وعددھم ١٥ , فئةحب الشباب النوع الشدید وعددھم ١٣ . الفحوص تشمل تحدید مستوى الخارصین, النحاس, والمغنیسیوم ي في مصول الأشخاصالأصحاء والمرضى. أظھرت نتائج الدراسة عدم وجود فرق إحصائي معنوي في مستوى العناصر(الخارصین, النحاس, المغنیسیوم)بین مجموعتي المرضى والأصحاء. لكن, مستوى الخارصین قد أنخفض بمستوى إحصائي معنوي لدى فئة حب الشباب النوع الشدیدكذلك أظھرت الدراسة انخفاض إحصائي .( P< مقارنة مع مجموعة الأصحاء ومجموعة فئة حب الشباب النوع البسیط( 0.05وفي ما یخص .(P< معنوي في مستوى المغنیسیوم لدى فئة حب الشباب النوع الشدید مقارنة مع فئة حب الشباب النوع البسیط( 0.05مستوى النحاس , لایوجد فرق معنوي بین فئات حب الشباب . یمكن الاستنتاج من ھذه الدراسة بأن ھناك علاقة معنویة بین مستوى كلمن الخارصین والمغنیسیوم في مصول المرضى المصابین بحب الشباب مع شدة المرض.

Keywords

Acne vulgaris --- zinc --- copper --- magnesium


Article
Serratiopeptidase a Hope in a Rapid and Better Improvement of Inflammatory Acne Vulgaris
إنزيم السيراتوببتايديز أمل جديد بتحسن أسرع وأفضل لحب الشباب الملتهب

Authors: Mahdi Y. Mohammed مهدي يحيى محمد --- Ehab M. Mikhael إيهاب مضر ميخائيل
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2012 Volume: 21 Issue: 1 Pages: 78-81
Publisher: Baghdad University جامعة بغداد

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Abstract

Acne vulgaris is a very common, chronic disorder, involving inflammation of the pilosebaceous units that can be varied in presentation and difficult to treat. Inflammatory acne may yield both scarring and pigmentary changes so early and adequate therapy will, in all cases, decrease its severity and may entirely suppress this disease. Serratiopeptidase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation. Serratiopeptidase was added in aim to hasten acne resolution. During March to July 2010, A comparative study for a 50 healthy patient suffering from acne was divided into 2 groups: 1st group treated by common acne modalities and the 2nd one with same modalities plus serratiopeptidase. All patients were followed up in out patient clinic by a dermatologist after 1st week of treatment and once weekly through the period of treatment. The results of this study showed that the effect of serratiopeptidase as adjuvant therapy for acne treatment result in a significant rapid improvement, this might be explained by serratiopeptidase ability in enhancing antibiotic efficacy and also increase the possibility of excellent improvement in acne appearance which may be due of it’s anti-inflammatory, anti-edemic. Serratiopeptidase was found to create a good hope as additional therapy for complicated acne vulgaris and bring a rapid and better improvement in treating acne.

حب الشباب مرض منتشر و مزمن يتضمن التهاب خلايا الجلد, له أشكال مختلفة ومن الصعوبة علاجه. حبوب الشباب الالتهابية تسبب أثارا في الوجه وتصبغات جلدية لذا فمن الضروري علاجها بسرعة وبشكل مثالي للتقليل من حدة المرض وإيقافه. إنزيم السيراتوببتايديز له خواص مضادة للالتهاب والوذمة كما انه يعمل موقعيا للتقليل من الالتهابات. تمت إضافة إنزيم السيراتوببتايديز بهدف الإسراع من علاج حب الشباب. خلال المدة من آذار وحتى تموز 2010 , دراسة مقارنة لخمسون مريضا يعانون من درجات مختلفة من حب الشباب تم تقسيمهم إلى مجموعتان : المجموعة الأولى عولجت بالأدوية المعتادة لعلاج حب الشباب , والمجموعة الثانية عولجت بذات العلاجات مضافا لها إنزيم السيراتوببتايديز. جميع المرضى تمت متابعتهم بعيادة خارجية من قبل طبيب جلدية مختص بعد الأسبوع الأول من العلاج وثم مرة أسبوعيا خلال فترة العلاج.هذه الدراسة أظهرت بان تأثير إنزيم السيراتوببتايديز كعلاج مساعد لحب الشباب هام ومعنوي لاستجابة أسرع للعلاج وقد يفسر هذا بقابلية الإنزيم لزيادة فاعلية المضادات الحيوية وكذلك يزيد احتمالية الشفاء الأفضل لحبوب الشباب بسبب تأثيره المضاد للالتهاب والوذمة. لقد وجد إن الإنزيم السيراتوببتايديز قد يخلق املآ جيدا كعلاجا إضافيا لعلاج حب الشباب المستعصي , كما انه يضمن علاجا أفضل وأسرع لعلاج حب الشباب.


Article
Beneficial Effect of Isotretinoin Gel As AdjunctiveTreatment to Oral Azithromycin in the Management of Facial Acne Vulgaris.

Author: Sabeeh A. Al-Mashhadani
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 1 Pages: 7-10
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Acne is a multifactorial disease with multiple pathogenic factors, hence combination therapies are needed. Combination therapies using agents with complementary mechanisms of action increasingly are recognized as an effective strategy for treating acne.OBJECTIVE:The rationale of utilizing topical retinoids with azithromycin in treating facial acne vulgaris will be highlighted, particularly in relation to improvement.METHODS:A randomized, clinical trial was carried out at the outpatient Department of Dermatology and Venereology, Baghdad Teaching Hospital between April 2007 and August 2008.A total of 48 patients with moderate to severe papulopustular acne vulgaris were allocated to two groups, azithromycin and azithromycin plus isotretinoin gel, both groups received Azithromycin for two months. Azithromycin 250 mg was prescribed every day for one month and every other day for the following month. Patients in second group were instructed to apply Isotretinoin gel 0.05% once daily over a 3 months treatment period. The clinical assessment was done by counting the number of inflammatory lesions in three occasions: baseline, two months and three months.RESULT:After two months, both groups showed a statistically significant difference from the baseline in reducing inflammatory lesions and improving acne. Adding topical isotretinoin gel produced a higher percentage of reduction in their lesional counts, but differences between the two groups were not statistically significant. After three months, regression in the percentage of reduction of the lesional count from 57.7% to 32.4% in the first group. While in the second group the reduction was maintain in 69.8%.CONCLUSION:Adding topical 0.05 per cent isotretinoin gel to oral azithromycin enhances and maintains the rate of improvement of facial acne vulgaris.

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