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Article
Assessment of Endogenous Erythropoietin Level in Sera Patients with Acute Ischemic Stroke

Authors: Suhayr Aesa Al-Qaysi --- Afaf K. Shweekh --- Zinah Abbass Ali
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 1 Pages: 132-138
Publisher: Babylon University جامعة بابل

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Abstract

A stroke is the loss of brain function due to a disturbance in the blood supply to the brain. Ischemic type is the most common type of stroke in older adults, caused by either blockage of a blood vessel via thrombosis or arterial embolism, or by cerebral hypoperfusion. Erythropoietin (EPO) is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. This study aimed to explore the EPO level in serum of ischemic stroke patients during the acute phase. This study was included 40 subjects, 20 patients with acute ischemic stroke and 20 apparently healthy persons act as a control group. Five milliliters of blood were collected in plane tube without anticoagulants for measuring EPO level in sera of patients and control by ELISA technique. In comparison with the control group, the patients with acute ischemic stroke showed a significant increase in EPO level (P ˂ 0.002). our data revealed that increase circulating endogenous EPO as a response to hypoxia and thereby increase oxygen supply by inducing erythropoiesis and/or other stimulatory factors that contribute the ischemic tolerance.


Article
The incidence of stress hyperglycemia in acute ischemic stroke patients (in Al-Yarmouk teaching hospital)

Authors: Abdul- Hameed Al-Kassir --- Zaid Tarik زيد طارق
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 46-51
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Aims: Stress hyperglycemia represents a transient increase in blood glucose in reaction to acute illness. Cases with stress hyperglycemia have higher mortality rates and worse functional outcomes than the ones with known diabetes or normoglycemia. This study evaluated the incidence of stress hyperglycemia in acute ischemic stroke patients and its relationship with stroke risk factors. Patients and Methods: WHO criteria is used to confirm hyperglycemia and HbA1c test to detect stress hyperglycemia in a sample of 220 patients with acute ischemic stroke who were admitted to Al-Yarmouk teaching hospital in Baghdad from 1 April to 31 December 2010. Results: thirty nine patients with acute ischemic stroke had stress hyperglycemia. There is significant effect of gender, hypertension, atrial fibrillation and dyslipidemia on patients with stress hyperglycemia while this is not found with obesity and smoking.Conclusions: stress hyperglycemia is a common phenomenon in patients who develop acute ischemic stroke.


Article
Mean Platelet Volume And Its Influence on The Severity of Acute Ischemic Stroke

Author: Basim A. Abd
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 3 Pages: 500-506
Publisher: Babylon University جامعة بابل

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Abstract

Introduction and objective e: Mean platelet volume (MPV) values in association with both thrombosis and inflammation have become a point of interest in the last few decades, and some studies have reported MPV values significantly higher in patients with stroke. This study aims to determine if there is an association between elevated levels of MPV and the severity of acute ischemic brain stroke.Patients and methods: Fifty acute ischemic stroke patients who were admitted to Merjan Teaching Hospital in Al-Hilla City, Babylon-Iraq; during the period from October 2013 to April 2014 were enrolled in this study. They included 22 males and 28 females, their ages ranged from 50-90 years, with a mean age of 70.52±11.264 years. Those patients were divided into two groups based on modified Rankin Scale (mRS): Group 1 (mRS 0-2), group 2 (mRS≥3). This scale was used to assess the severity of the disease. Blood samples were collected from the patients to measure MPV.Results: The study demonstrated that the patients' group with mRS≥3 were significantly older than the other group regarding the age distribution, and MPV values for them were also significantly higher than the other group. Concerning the gender distribution and clinical history of ischemic heart disease and smoking, there were no significant differences between the two groups of patients. Conclusion: Mean platelet volume is a strong and independent risk factor for acute ischemic stroke and high MPV values could be associated with a severe form of the disease.

المقدمة والهدف: معدل حجم الصفيحات الدموية وبالمصاحبة مع كل من عمليتي التخثر والالتهاب أصبحوا موضع اهتمامٍ في العقود القليلة الأخيرة، وسجلت بعض الدراسات مستوياتٍ معنوية مرتفعة لمعدل حجم الصفيحات الدموية لدى مرضى السكتة الدماغية. تهدف هذه الدراسة إلى معرفة ما إذا كان هنالك ارتباطٌ بين المستويات المرتفعة لمعدل حجم الصفيحات الدمويّة وشدة السكتة الدماغية الإقفاريّة الحادة.المرضى وطرق العمل: تضمنت الدراسة خمسين مريضاً مصابين بالسكتة الدماغية الإقفاريّة الحادة ممن أُدخلوا إلى مستشفى مرجان التعليمي في مدينة الحلة، بابل-العراق، خلال الفترة من تشرين الأول 2013 إلى نيسان 2014. ضمن المرضى كان هنالك 22 ذكراً و28 أنثى تراوحت أعمارهم بين 50-90 سنة، وبمعدل عمري هو 70,52±11,264 سنة. قُسِّم المرضى إلى مجموعتين استناداً إلى مقياس رانكين المعدّل: المجموعة الأولى (0-2) حسب مقياس رانكين، والمجموعة الثانية (3 فأكثر) حسب نفس المقياس. استُخدم هذا المقياس لقياس شدة المرض. جُمعت عينات دمٍ من المرضى لقياس معدل حجم الصفيحات الدمويّة.النتائج: أظهرت الدراسة أن مجموعة المرضى الثانية حسب مقياس رانكين كانت بصورة معنوية أكبر عمراً من المجموعة الأولى، كذلك كانت مستويات معدل حجم الصفيحات الدمويّة لديهم أعلى معنوياً من المجموعة الأخرى. فيما يخص توزيع الجنس وكذلك التاريخ المرضي السريري لمرض القلب الإقفاري والتدخين فلم يكن هنالك فروقٌ معنويّة بين مجموعتيّ المرضى.الاستنتاج: معدّل حجم الصفيحات الدمويّة عامل خطورة قوي ومستقل للسكتة الدماغية الإقفاريّة الحادة والمستويات المرتفعة لمعدل حجم الصفيحات قد تكون مرتبطة بشكلٍ حاد من أشكال المرض.


Article
Correlation of Elevated Cardiac Troponin T Level with Severity and In‑Hospital Outcomes in Patients with Acute Ischemic Stroke

Author: Salam Naser Zangana, Abdulkareem A. Al‑Othman, Azad Anwar Hamad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2018 Volume: 15 Issue: 2 Pages: 174-177
Publisher: Babylon University جامعة بابل

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Abstract

Background: Although elevated cardiac troponin T (cTnT) is a specific marker of acute coronary syndrome, its increment in patients withacute ischemic stroke is not clear. The aim of this study is to identify the relationship between high cTnT levels and stroke severity as well asin‑hospital outcomes. Materials and Methods: This observational, cross‑sectional study was conducted on 100 patients with acute ischemicstroke in Rizgary teaching hospital from January 2016 to January 2017. Patients were divided into two groups: Group 1 patients (n = 61) withnormal cTnT level and Group 2 patients (n = 39) with elevated cTnT level. The relationships between cTnT levels and stroke severity as well asin‑hospital outcomes were assessed and compared between the two groups. Results: In this study, cTnT was raised in 39 patients (39%). Patientswith elevated cTnT levels were mainly males, had a significantly higher prevalence of hypertension and diabetes mellitus than the normal cTnTgroup (P < 0.001, for all). Systolic blood pressure and total cholesterol were significantly higher (P < 0.008 and < 0.001, respectively) in Group IIpatients than in Group I. In addition, Group II patients had more severe stroke and longer length of stay in hospital than in Group I patients, andthe differences were statistically significant (P < 0.001, for all). The incidence of aspiration pneumonia, seizures, hemorrhagic transformationof ischemic stroke, and death was significantly higher (P < 0.001, for all) in Group II patients than in Group I patients. Conclusion: Elevatedserum cTnT level at hospital admission is highly correlated with severity and poor in‑hospital outcomes in patients with acute ischemic stroke.

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