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Article
Adiponectin and Lipid Profile Levels in Type-2 Diabetic Obese Patients in Kerbala Province
مستويات الأديبونكتين وصورة الدهون في مرضى السكري – النوع الثاني البدناء في محافظة كربلاء

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Abstract

Background: The association between obesity and type-2 diabetes mellitus may be partly mediated by altered secretion of adipokines by adipose tissue. Adiponectin is an adipokines with anti-inflammatory and insulin sensitizing properties; it is secretion is down regulated in obesity. The correlation of plasma adiponectin with the risk of type-2 diabetes mellitus and hyperlipidemia is unclear.Objective: To study the association between plasma adiponectin level with lipid profile in type-2 diabetic obese patients in Kerbala province: Iraq.Material and method: A total number of 110 sample subjects with different age, and different gender were classified according to diabetes mellitus and obesity. Fasting serum adiponectin was measured by ELISA method. Measurements of fasting lipid profile also have been performed.Results and discussion: It was obtained that adiponectin level was lowered significantly in diabetic group, obese group, and diabetic obese group as compared with control group. Serum adiponectin was correlate negatively with serum total cholesterol, serum TG, and with body fat percent (BF %), while it was correlated positively with HDL-C. Serum total cholesterol levels was correlated positively with each of serum TG, LDL-C levels and with BF%, while serum TG levels was negatively correlated with serum HDL-C and positively correlated with each of BMI and BF %. Serum LDL-C was positively correlated with BF %, while BF % correlates positively with age.Conclusion: According to the presented data, adiponectin as hormone play an important role in the prevention of hyperlipidemia, and consequently atherosclerosis and its complications.

من المعروف أن السمنة وداء البول السكري من النوع الثاني متلازمان في اغلب الاحيان, حيث ان السمنة وزيادة الخلايا الدهنية هي السبب الاساسي لمقاومة الانسجة للانسولين. اضافة الى ان الخلايا الدهنية تعمل كغدة صماء مسؤولة عن افراز العديد من الهرمونات التي لها دور كبير في تحول الشخص المصاب بالسمنة الى مريض بداء البول السكري, ومن بين هذه الهرمونات الهرمون البروتيني الاديبونيكتين المكتشف حديثا, حيث يتميز هذا الهرمون عن بقية الهرمونات التي تفرزها الخلايا الدهنية بان نسبتها تقل كلما ازدادت نسبة السمنة, وكذلك تشير بعض الدراسات السابقة ان مستوى الاديبونكتين يقل في المرضى المصابين بداء السكري النوع الثاني, اضافة الى خاصيته باعتباره مضاد للالتهابات وعلاقتها باضطرابات نسبة الدهون بالدم. بالرغم من ذلك فان المعلومات المتوفرة حول العلاقة بين السمنة ومستوى هرمون الاديبونكتين وداء السكري النوع الثاني في المرضى لاتزال قليلة في العراق. الهدف من البحث: دراسة العلاقة بين هرمون الاديبونكتين وصورة الدهون في مرضى البول السكري – النوع الثاني البدناء.المواد و طرائق العمل: تم اختيار 110 أشخاص لهذه الدراسة من المرضى المصابين بداء السكري النوع الثاني في العيادة الاستشارية لداء السكر في مستشفى الحسين التعليمي في مدينة كربلاء خلال الفترة الواقعة بين شهر تشرين الثاني من عام 2010 إلى شهر نيسان من عام 2011 وتم تقسيمهم الى ثلاث فئات وذلك حسب نوع الاصابة بمرض البول السكري من النوع الثاني مع/ او بدون السمنة ومن بينهم 43 شخصاغيرمصاب بالمرض كمجموعة ضابطة.وقد تم قياس تركيز الاديبونكتين وصورة الدهون في مصل الدم.النتائج:- في الفئة الاولى اظهرت النتائج انخفاض معنوي لكل من الاديبونكتين والــ LDL-C والكوليستيرول وغير معنوي للدهون الثلاثية والــ HDL-C في مجموعة المرضى مقارنة مع المجموعة الضابطة. بينما اظهرت النتائج انخفاض معنوي لكل من الاديبونكتين والدهون الثلاثية وغير معنوي لكل من الكوليستيرول والــ LDL-C والـــ HDL-C في المجموعة الاولى مقارنة مع المجموعة الثانية علما ان هناك زيادة معنوية واضحة لكل من منسب كتلة الجسم (BMI) ونسبة الشحوم في الجسم (BF %) بين المجموعتين في الفئة الثانية. أما بالنسبة للفئة الثالثة فقد اظهرت النتائج انخفاض معنوي لمستوى الاديبونكتين وزيادة معنوية لكل من الكوليستيرول, الدهون الثلاثية الجليسيرايد, والـــ LDL-C والــ BMI ونسبة الشحوم BF% وغير معنوية للــ HDL-C في المجموعة الاولى مقارنة مع المجموعة الثانية. وبينت النتائج وجود علاقة معنوية سالبة بين الاديبونكتين و كل من الكوليستيرول و الدهون الثلاثية والـــ BMI. وكذلك اظهرت الدراسة وجود علاقة معنوية موجبة بين مستوى الاديبونكتين والــ HDL-C.الاستنتاج:-1.حدوث انخفاض واضح في مستوى هرمون الاديبونكتين في المرضى الذين يعانون من السمنة وداء السكري من النوع الثاني مقارنة بالاشخاص الاصحاء.2.حدوث انخفاض مستوى هرمون الاديبونكتين في الدم يصاحبه عدم انتظام صورة الدهون في المرضى الذين يعانون من داء السكري - النوع الثاني البدناء.


Article
The Impact of Inflammation on Adiponectin, IL-6 and CRP in Acute Myocardial Infarction Patients

Authors: lmmmA Esmaeel Ibrahim --- Hadef Dhafer EL-Yassin --- Hamid Kareem Sachit AL-Janabi.
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: supplement Pages: 616-622
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity. Adiponectin is adipocyte derivate hormone that has important effect as anti-inflammatory factor. Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. IL-6 is one of the most important mediators of fever and of the acute phase response. C-reactive protein (CRP) is a protein found in the blood, the levels of which rise in response to inflammation (an acute-phase protein). Myocardial Infarction (MI) or Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.OBJECTIVE:To investigate the level of adiponectin and its effect on IL-6 and CRP in patients with Acute Myocardial infarction.SUBJECTS AND METHODS:The study included 50 patients with Acute Myocardial infarction and forty healthy subjects as control group. Levels of adiponectin , CRP and IL-6 were measured.RESULTS:The levels of adiponectin, IL-6 and CRP were significantly elevated with (p<0.001), there was negative correlation between adiponectin with CRP and IL-6 in acute myocardial infarction patients.CONCLUSION:The significant increase in adiponectin in AMI may be related to inflammation. Adiponectin inversely correlated with inflammatory marker (CRP and IL-6) so it has anti-inflammatory properties and that make us consider it as cardiovascular protective factor


Article
Study The Relationship of IL-33 with Adiponectin in Postmenopausal Female with and without Type 2 Diabetes Mellitus

Author: Abeer Jabbar Hassan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 618-624
Publisher: Babylon University جامعة بابل

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Postmenopausal women influence by several physiological changes such as coronary artery disease, obesity and insulin resistance. Interleukin-33 (IL-33) a cytokine which have a protective effect to cardiovascular disorders and regarded either pro- or anti-inflammatory. Adiponectin is a hormone with anti-inflammatory properties, associated with hyperlipidemia and insulin resistance. The aim of this study is to investigate the relationships of IL-33, adiponectin with atherogenicity as considered risk factor for heart disease in postmenopausal women with and without type 2 diabetes mellitus. Ninety women age between (54-62) years were enrolled in this study. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), body mass index (BMI), lipid profile, atherogenic index of plasma (AIP), IL-33 and adiponectin levels were determined in patients and control groups. The results revealed highly significant increase in FBG, HbA1c, BMI, TCh, TG, LDL-c, VLDL-c and AIP. While reduce HDL-c, adiponectin and IL-33 levels were founded in postmenopausal women when comparing to control group. Furthermore, a positive correlation was observed in IL-33 with HbA1c, also with AIP, but a negative significant correlation between IL-33 and adiponectin, also between IL-33 and BMI in diabetic postmenopausal women group. Conclusion from the results of present work lead to suggest that higher reduction in IL-33 and adiponectin levels in diabetic postmenopausal women may be useful in predict action of cardiovascular disorders.


Article
Association of The T45G Polymorphism of Adiponectin Gene with Polycystic Ovary Syndrome in Women of Babylon Province/ Iraq

Author: Hawraa Sabah Al-Musawi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 1020 -1026
Publisher: Babylon University جامعة بابل

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Polycystic Ovarian syndrome (PCOS) is being the most frequent cause of anovulatory infertility, Adiponectin is the most abundantadipocytokine and may play a role in the regulation of insulin sensitivity and IR in PCOS and count for 0.01% or 3–30 μg/ml of total plasma proteinthe adiponectin gene contains 3 exons spans 16 kb on chromosome3q27.The aim of the present study was to evaluate the genetic influence of the adiponectin gene polymorphisms in the development of PCOS among women of Babylon Province/ Iraq. sixty three women were studied ,and were classified into two groups of : first group consists of 32 women infected with polycystic ovaries syndrome, the second consists of 31 healthy women to detect the presence of T45G polymorphism within the gene. From all subjects a whole-blood sample was taken and was used for isolation of peripheral blood leukocytes. The adiponectin T45G polymorphism, located in exon 2, was genotyped by amplification of genomic DNA.The present study included study of the relationship of this gene with PCOS women in reproductive age, A statistically significant difference was observed in the frequency of TT,TG and GG genotypes between women with PCOS and controls .


Article
Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)
دراسة مستويات اللبتين، الأديبونكتين وإنزيم الباروكسينيز في الأشخاص البدينين

Author: Entedhar R. Sarhat انتظار رفعت سرحت
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2015 Volume: 20 Issue: 2 Pages: 14-20
Publisher: Tikrit University جامعة تكريت

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Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations.To study the association of various measures of body mass index (BMI), waist circumference (WC), percentage of body fat (%BF), with leptin, Adiponectin, and paraoxonase. To study the association between leptin , adiponectin with Paraoxonase.This study conducted from of February 2013 until March 2014, all individuals were randomly recruited from Kirkuk and Tikrit Governorate .Hormonal assay of leptin, adiponectin, Paraoxonase, and glucose. Blood samples collected from 220 individuals, and these samples were divided into three groups according to BMI. Group 1 (Normal Weight group n=80), Group 2 (Over Weight group, n=58), Group 3 (Obese group, n=62) .The statistical analysis (students t-test) exhibited significant (P≥ 0.0001)elevation for leptin , paraoxonase, and glucose, while significant decrease in adiponectin in over weight and obese groups compared with normal weight groups.The correlation coefficient (r) between Leptin and other parameters were calculated with regression plot showed a negative correlation with adiponectin, and paraoxonase in over weight and obese group. There was a positive correlation between adiponectin with paraoxonase, but a negative correlation with leptin, in over weight and obese group. Conclusion: Adiponectin as hormone play an important role in the prevention of hyperlipidemia, and consequently atherosclerosis and its complications while Leptin act as atherosclerotic factors. The results indicated that adiponectin positively associated with paraoxonase while Leptin negatively correlated with paraoxonase.

تعد السمنة احدى عوامل الخطورة للمضاعفات الاستقلابية والامراض القلبية – الوعائية, وقد تم ايضاح الروابط بين القياسات البشرية وتوزيع الدهون في الجسم ,والاختطار القلبي الوعائي في عدة مجموعات سكانية.هدفت هده الدراسة الى اختبار الارتباط بين عدة قياسات للسمنة, متضمنة السمنة الكلية للجسم (مؤشر كتلة الجسم, ونسبة الدهون في الجسم, ومحيط الخصر) مع هرمونات اللبتين, الأديبونكتين, إنزيم الباروكسينيز, في الأشخاص البدينة ومقارنتها مع الاشخاص ذوي الوزن الطبيعي. ودراسة العلاقة بين اللبتين, الأديبونكتين مع إنزيم الباروكسينيز.اعتمدت هذه الدراسة على جمع عينات مصل الدم من 220 شخصاً٬ خلال الفترة من شباط 2013 الى اذار 2014 ,الاشخاص جندوا بشكل عشوائي من محافظة كركوك وتكريت, حيث خضع جميع هؤلاء الاشخاص في هذه الدراسة الى فحوصات هرمونات اللبتين , الأديبونكتين , و إنزيم الباروكسينيز. وتم تقسيم هذه العينات من الاشخاص إلى ثلاث مجاميع تضم كل منها المجموعة الاولى: (الاشخاص ذوي الوزن الطبيعي, عددهم 80), المجموعة الثانية: (الاشخاص ذوي الوزن الزائد عددهم 58) ,المجموعة الثالثة: (الاشخاص البدينة, عددهم 62) .أظهر التحليل الاحصائي باستعمال فحص الطالب-t زياده معنوية إيجابية (P≤ 0. 01)في اللبتين , إنزيم الباروكسينيز, ونقصان معنوي في الأديبونكتين, الباروكسينيز, في الاشخاص ذوي الوزن الزائد و الاشخاص البدينة مقارنة بالأشخاص ذوي الوزن الطبيعيلقد أظهر معامل الارتباط (r) بين هرمون اللبتين والمعايير الاخرى والذي اعتمد على مخطط الانحدار وجود علاقة إيجابية بين اللبتين مع (مؤشر كتلة الجسم ,نسبة الدهون في الجسم ,محيط الخصر) اللبتين , في حين أوضح وجود علاقة سلبية مع الأديبونكتين, الباروكسينيز, في الاشخاص ذوي الوزن الزائد و الاشخاص البدينة مقارنة بالأشخاص ذوي الوزن الطبيعي.أظهرت نَتائِجُ Adiponectin ارتباطا إيجابياً مَع الباروكسينيز, بينما أظهرت ارتباط سلبي مَع (مؤشر كتلة الجسم ,نسبة الدهون في الجسم ,محيط الخصر) , اللبتين في الاشخاص ذوي الوزن الزائد و الاشخاص البدينة مقارنة بالأشخاص ذوي الوزن الطبيعي.الاستنتاجات: الأديبونكتين كما الهرمون يلعب دورا هاما في الوقاية من الدهون، وبالتالي تصلب الشرايين ومضاعفاته في حين أشارت اللبتين بمثابة النتائج عوامل تصلب الشرايين. لقد دلت النَتائِجُ على وجود علاقة معنوية سالبة بين اللبتين مع الأديبونكتين و الباروكسينيز بينما علاقة معنوية موجبة بين الأديبونكتين مع الباروكسينيز.


Article
Effects of Extracted Phenolic Compounds from Grape Seeds on Leptin, Adiponectin and Resistin Levels in Rats Fed with High Fat Foods
تأثيرات مركبات الفينول المستخلصة من بذور العنب على مستويات الليبتين والاديبونكتين والريزستين في الجرذان التجارب المسمنة بغذاء عالي الدهون

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The current study was constructed to evaluate the efficacy of grape seed extracts (GSE) in management of obesity induced by high fat diet (HFD)-induced obesity in rats through assessment of the serum leptin, adiponectin, and resistin. Experimental rats were divided into three groups: G:1 (healthy control), G:2 (obese control), G:3 (received100 mg/kg of GSE), after 7 weeks, serum leptin, adiponectin, and resistin levels were measured in all groups. Results in present study showed a significant (P<0.01) increase of serum leptin, and resistin levels in obese rats G2 in comparison to the control healthy rats G1 (39.35±1.07 vs 7.48±0.6), (48.84±3.73 vs 31.43 ± 2.02) respectively. The level of serum leptin, and resistin in obese rats decreased significantly in G3 (P < 0.01) when received GSE 100 mg/kg body weight for 7 weeks in regard to G2 (30.46 ± 0.93 vs 39.35 ± 1.07), (42.23±1.21vs48.84±3.73), whereas significant decrease in serum adiponectin level in obese rats G2 to G1 (4.8793 ± 0.5040 vs 9.245± 0.8794). After treatment with 100 mg/kg GSE, the level of adiponectin decresed in G3 compared with G2 (6.1220 ±0.6330 vs 4.8793± 0.5040).Conclusions: The results show that, the phenolic extracts of grape seed could reduce serum leptin, and resistin levels and increase adiponectin in HFD induced obesity in rats

اجريت هذه الدراسة لتقييم فاعلية مستخلص بذور العنب في علاج السمنة المستحدثة في فئران تجارب تعرضوا لغذاء عالي الدهون وذلك من خلال قياس مستويات كل من الليبتين والاديبونكتين والرزيستين في مصل الفئران.تم تقسيم حيوانات التجربة الى ثلاث مجاميع : المجموعة الاولى ضمت حيوانات سليمة كعينة ضابطة والمجموعة الثانية ضمت حيوانات مسمنة كعيتة ضابطة ايضا اما المجموعة الثالثة فقد كانت حيوانات مسمنة ايضا وتم اعطاؤها مستخلص بذور العنب.بعد مضي ثلاث اسابيع تم قياس مستويات الليبتين والاديبونكتين والرزيستين في مصل الفئران لجميع المجاميع.بينت النتائج ان هناك زيادة ذات مغزى احصائي لمستوى كل من الليبتين والريزستين في الحيوانات المسمنة بالمجموعة الثانية قياسا لعينة الحيوانات السليمة في المجموعة الضابطة الاولى. وقد تناقصت مستويات المصل بصورة معنوية لكل من الليبتين والرزيستين في الحيوانات المسمنة بالمجموعة الثالثة والتي تم اعطاؤها مستخلص بذور العنب مقارنة بالمجموعة الثانية (30.46±0.93 vs 39.35±1.07)، (42.23±1.21vs48.84±3.73).كما كان هناك زيادة ذات مغزى احصائي بمستوى الأديبونكتين في هذه المجموعة التي عولجت بمستخلص بذور العنب بالقياس لمستوى الأديبونكتين بالمجموعة الثانية (6.1220 ± 0.6330 vs 4.8793 ± 0.5040 )..


Article
The Association between Adiponectin, Insulin and Troponin I in Patients with Acute Myocardial Infarction

Authors: Ammal Esmaeel Ibrahim --- Hadef Dhafer El-Yassin --- Hamid Kareem Sachit Al-Janabi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2012 Volume: 15 Issue: 3 Pages: 15-22
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Adipose tissue is increasingly recognized as a key regulator of energy balance, playing an active role in lipid storage and buffering, and synthesizing and secreting a wide range of endocrine products that may be directly involved in the pathogenesis of the complications associated with obesity the most important adiposcyte deviated hormone is adiponectin. Insulin is a hormone that is central to regulating the energy and glucose metabolism in the body. Troponin is a complex of three regulatory proteins that is integral to muscle contraction in skeletal and cardiac muscle.This study was conducted during the period from Decenber2009 to April 2010, includes fifty patients with Acut Myocardial Infarction (AMI) were admitted to Cardiac Care Unit (CCU) at Medical City Teaching Hospital and Ibn –ALbetar Hospital in Baghdad. Levels of adiponectin, insulin and troponin were measured by ELISA method.The levels of adiponectin, insulin and troponin were significantly elevated with (p<0.001), A negatively significant correlation between adiponectin with insulin and troponin in acute myocardial infarction patients was found.Adiponectin was negatively associated with insulin in patients with AMI

النسيج الدهني يُعْرَفُ على نحو متزايد كمنظّم رئيسي لميزانِ الطاقةِ، يَلْعبُ دوراً نشيطاً في خزنِ الدهون و ويفرز تشكيلة واسعة من المُنتَجاتِ الإفرازيةِ التي قَدْ تُشتَركُ في النشوء المرضي لكثير مِنْ التعقيداتِ المرتبطة بصورة مباشرة بالسمنةِ من اهم المركبات التي يفرزها النسيج الدهني هرمون adiponectin. الأنسيولين هو الهورمون الذي ينظيم أيضِ الجلوكوزَ والطاقةَ في الجسمِ. Troponin هو مركّب مِنْ ثلاثة بروتينِات تنظيم الإنكماشِ العضلي في العضلات الهيكليةِ والقلبيةِ.تَضمّنتْ الدراسةُ 50 مريضُ بالذبحة الصدرية اما المجموعة المسيطرة فقد تضمنت أربعون من الأشخاص الأصحاء. مستويات adiponectin والأنسيولينِ و troponin تم قياسهامستويات adiponectin والأنسولين و troponin كانت مرتفة بشكل معنوي (p <0.001)، كان هناك إرتباطُ سلبي ُبين adiponectin والأنسولين و troponin في مرضى الذبحةّ الصدرية.وجود زيادة معنوية في مستويات adiponectin، في مرضى الذبحةّ الصدرية وهذه قَد تكون مُتَعَلّقة بالالتهاب. هنالك علاقة عكسية بينadiponectin والأنسولين.


Article
Role Of Leptin/Adiponectin Ratio In Iraqi Type 2 Diabetic Patients Treated With Different Antidiabetic Agents

Authors: Lamia Shaker Ashoor --- Hadeel Delman Najim --- Noor Thair Tahir
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 2 Pages: 54-62
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Leptin/adiponectin ratio has a potential additional value as a marker of central role of excess adipose tissue in insulin resistance, thus it contributes in the modulation of diabetes mellitus risk. Adipose tissue is involved in the regulation of energy balance and insulin action in type 2 diabetes mellitus patients.Aim of this study: Study of the role of leptin/adiponectin ratio and its association with insulin resistance in type 2 diabetic patients treated with different oral antidiabetic agents.Materials and Methods: Ninety patients with type 2 diabetes mellitus (45 males and 45 females) age between (35-60 years) and body mass index (<25) were enrolled in this study in addition to 40 healthy subjects matched with the patients for age, gender and body mass index. This study was conducted between March to December 2016 in the National Diabetes Center for Treatment and Research and Al-Yarmook teaching hospital/ Baghdad/ Iraq. We divided the patients into three groups according to medication option: Group I-include 30 type 2 diabetic patients treated with metformin alone, Group II-include 30 type 2 diabetic patients treated with glibenclamide alone, Group III-include 30 type 2 diabetic patients treated with metformin and glibenclamide. Blood samples were analyzed for fasting serum glucose, glycosylated heamoglobin, fasting serum insulin, total cholesterol, triglyceride, high density lipoprotein cholesterol, serum leptin, serum adiponectin, homeostasis model assessment of insulin resistance and leptin/adiponectin ratio.Result: Fasting serum glucose, glycosylated heamoglobin, fasting serum insulin, insulin resistance, total cholesterol, triglyceride and serum leptin levels showed significant increase in diabetic patients when compared with control group (p<0.05). High density lipoprotein cholesterol and serum adiponectin levels showed significant decrease in diabetic patients (p<0.05), while leptin/adiponectin ratio was significantly higher for diabetics as compared with controls (p<0.01). Leptin concentration was significantly low as well as adiponectin concentration was significantly higher in type 2 diabetic patients treated with metformin alone (group I) when compared to those treated with glibenclamide alone (group II) or those treated with metformin plus glibenclamide (group III), while non-significant difference was noticed between (group II) and (group III). Homeostasis model assessment of insulin resistance in group I and III (patients treated with metformin as monotherapy or combination) showed a significant positive correlation with leptin and negative correlation with adiponectin (p<0.01), but non-significant correlation was recorded in group II (patients treated with glibenclamide alone). Correlation of homeostasis model assessment of insulin resistance with leptin/adiponectin ratio found to be significant in metformin treated groups (p<0.05) while non-significant with glibenclamide group. Conclusion: Leptin/adiponectin ratio in type 2 diabetes mellitus can serve as an index of insulin resistance independent of body mass index. Leptin/adiponectin ratio can measure the usefulness of antidiabetic therapy based on insulin level and insulin sensitivity.

Keywords

T2DM --- Leptin --- Adiponectin --- LAR --- Metformin --- Glibenclamide


Article
Association of Adiponectin , Oxidative Stress, and Obesity in Asthmatics children

Authors: Mufeed Jalil Ewadh --- Afrah Nazar Al-Mamoori --- Suhayr Essa Al-Qaysi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 2 Pages: 267 -279
Publisher: Babylon University جامعة بابل

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Abstract

There is an increasing evidence of a positive correlation between asthma and obesity in children and adults. Adipokines regulate several metabolic and inflammatory functions. Several studies have shown that reactive oxygen species (ROS) play a key role in initiation as well as amplification of inflammation in asthmatic airways. This study is to highlight the oxidant-antioxidant imbalance in relation to adiponectin level in asthmatic children in Hilla province of Babylon.Adiponectin , glutathione , total antioxidant and malondialdehyde were measured in 100 children; 60 newly diagnosed with asthma and 40 non asthmatic children with the comparable age and sex were enrolled in this study. Asthmatic children subdivided in two groups 30 patients in each group( obese and non-obese). Ages of patients and control ranged between (2years -12 years). The study was carried out in Babylon Teaching Hospital for Gynecology & Pediatrics in Babylon Province. Adiponectin and total antioxidant were estimated by ELISA technique, glutathione by HPLC and malondialdeheyde by spectrophotometer. There was a negative significant correlation between adiponectin with glutathione and positive significant correlation between total antioxidant and malondialdehyde.The results revealed the existence of an oxidant-antioxidant imbalance among obese asthmatic children, in parallel to changes in adepokines level.


Article
Association of Adiponectin Gene Promoter Polymprphism (rs266729) With Ischemic Heart Diseases

Authors: Maha Radhi Abass --- Majid Kadhum Hussain --- Zuhair Mohammed Ali Jeddoa
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3889-3893
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Ischemic Heart Disease is a group of diseases of the blood vessels supplying the heart muscle. Adiponectin is a protein secreted by adipocyte with insulin-sensitizing, Anti-inflammatory and anti-atherogenic properties. Several studies have shown that polymorphisms within the adiponectin gene can be associated with Ischemic heart disease. Aim: The aim of the present study was to evaluate the impact of (rs266729) SNP in the promoter region of the ADIPOQ gene on the occurrence of Ischemic heart disease (IHD).Methods: The study included 150 patients with IHD randomly selected based on World Health Organization (WHO) guideline and 150 as controls group. DNA was extracted from blood and genotyped by PCR-RFLP by using (Hha1) enzyme. Result: The frequency of G allele of rs266729 (C/G) polymorphism was significantly (p=0.0001) in IHD (19.6%) compared with control (13.3%). The homozygous genotype (GG) significantly (0R=1.71, CI 95%=0.65-4.96, P= 0.0001) increased the risk of Ischemic Heart Disease compared with wild type (CC) after adjustment age, sex, and BMI, furthermore the heterozygous (CG) genotype significantly (0R=1.61, CI 95%=0.96-2.87, P= 0.0001) raised the risk of Ischemic Heart Disease.Conclusion: Adiponectin gene polymorphism rs266729 is involved in the pathogenesis Ischemic heart disease.

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