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The Value of Urinary Albumin to Urinary Specific gravity ratio in detecting Microalbuminuria in Diabetic patients.
أهمية نسبة الألبومين إلى الكثافة النوعية للبول كطريقة لتحديد وإيجاد اقل الزلال في البول عند مرضى داء السكر

Author: Dr. Hussein Aziz Nasir M.B.CH.B/ C.A.B.M
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2011 Volume: 14 Issue: 1 Pages: 281-287
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background and objective microalbuminuria is known to be harbinger of serious complications in diabetes mellitus. since medical intervention early in onset of microalbuminuria can de critical in reducing these adverse outcomes. it is widely agreed that diabetic patients should be screened for microalbuminuria. the study aim is to evaluate micral tests strips in conjunction with a urine specific gravity determination as a rapid and accurate method in detecting microalbuminuria in diabetic patients.Patients and methods40 diabetic patients from diabetic center of Al Sader Hospital in Najaf city were included in this study From March 2009 to August 2009. All with disease duration ≥ 5 years. Urinary albumin concentration/24 hours, urinary creatinine concentration/ 24 hours was done and the ratio of them was compared to ratio of urinary albumin Concentration done by Micral tests/ urinary specific gravity.Resultsthe relation between the acr which sensitive and specific in detecting microalbuminuria and the simple method that correlates the urinary albumin to urinary specific gravity is strong association.

قليل الزلال في البول عند مرضى داء السكر هو مقدمة لحصول مضاعفات داء السكر, وحساب وتحديد حصول ذلك اهمية خاصة. اعتمدت طريقة مقارنة نسبة الالبومين في البول الى الكثافة النوعية كطريقة سهله مع نسبة الالبومين في البول الى حساب ماده الكرياتينين في البول لأربعين (40) مريضاً مصابين بداء السكر في عيادة داء السكر في المستشفى التعليمي في النجف من شهر اذار لعام 2009 الى شهر اب لعام 2009 وتبين خلال الدراسة الى توافق وعلاقة جيدة بين الاثنين مما يساعد على اعتماد طريقة الالبومين الى الكثافة النوعية كعملية سهله في تحديد حصول قليل الزلال في البول عند مرضى داء السكر.


Article
Neutrophil gelatinase associated lipocalin (NGAL) in early detection of nephropathy in type 2 diabetic Iraqi patients

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Abstract

Background: Diabetic nephropathy is a common complication of diabetes mellitus type2. The neutrophil gelatinase Associated lippocallin (NGAL) is an ubiquitous protein consist of 178 amino acid. NGAL can be identified in plasma and urine starting 2- 4 hours after a kidney injury resulting changes in glomerular filtration and tubular reabsorption and with increased secretion in tubular epithelial cells.Objective: This study aimed to evaluate the role of serum Neutrophil Gelatinse Associated Lipocallin (NGAL) in early detection nephropathy.Method : This study was conducted in Medical City, Baghdad Teaching Hospital during the period from December 2015to June 2016.The study included (90) subjects with age range between (30 – 56)years, divided in to three groups , 30 healthy control,30 type 2 diabetic mellitus patients with normal albuminuria and 30 type2 diabetic mellitus patients with micro albuminuria .Body mass index (BMI) was determined, serum NGAL, Fasting serum glucose (FBS),serum creatinine ,serum urea ,andglycated hemoglobin (HbA1c%) were measured for each individual in addition to the concentration of albumin in urine and Glomerular Filtration Rate (eGFR) was calculated.Results:The results of the present study showed that the levels of NGAL, FBS, HbA1c, urea creatinin, were significantly higher in micro albuminuria than normal albuminuria and healthy control. In diabetic patients with micro albuminuria, Serum NGAL shows significant positive correlation with FBS, HbA1c% and urine albumin. Serum NGAL shows significant positive correlation with duration of diabetes but significant negative correlation with GFR.Conclusion:Serum NGAL increased markedly with the reduction of GFR.Serum NGAL is may be considered predictive marker for early detection of diabetic nephropathy in type2 diabetes mellitus.Keywords:diabetic mellitus,diabetic nephropathy,micro albuminuria, serum NGAL, HbA1c.


Article
The incidence of proteinuria among diabetic patients in relation to the level of glycated Hb, duration of the disease& types of treatment in Thi-Qar province

Author: Fadel Abbass Al-seidi فاضل عباس السعيدي
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2016 Volume: 5 Issue: 4 Pages: 42-46
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

A prospective study had been conducted in diabetic and endocrine center of Nassiriyah city from January to March year 2015. A total of 100 patients with different ages were included in this study.All of them were diagnosed as diabetic patients and have been selected randomly. In this study we proved that there was a very strong effect of the level of HbA1c& duration of DM on the incidence of albuminuria.Also researcher found that patients who were on oral hypoglycemic treatment therapy develop albuminuria more than those who were on insulin treatment. Microalbuminurea was present in patient with longer DM history (around 10 years). This result correlates well with documented evidence that diabetic nephropathy usually occur after 10_15 years after diagnosis of DM.

تمت الدراسة في مركز السكري والغدد الصم في محافظة ذي قار للفتره من شهر كانون الثاني الى نهاية شهر اذار للعام 2015. تم اختيار 100 من مرضى السكري بصوره عشوائية وباعمار مختلفه.تضمنت الدراسه التحري عن العلاقة بين نسبة الهيموكلوبين نوع AC1 كدلاله لمستوى السكر بالدم للمرضى المصابين بالسكري ونسبة حدوث الالبومينيوريا لدى هؤلاء المرضى. من النتائج التي تم الحصول عليها من الدراسة وجد ان مرضى السكري الذين يتناولون الادوية المخفضة للسكر عن طريق الفم ترتفع لديهم نسبة الالبومين يوريا بنسبة اعلى من الذين يتم علاجهم بحقن الانسولين.بينت النتائج ان مرضى السكرى الذين مرت عليهم اكثر من عشرة سنوات ترتفع عندهم نسبة الالبومين يوريا بنسبة قليله وهذه الحالة ترتبط بالاذى الذي يحصل للكلتين بعد 10-15 سنة من الاصابة بمرض السكري.

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